Synthetic ligands
Transcriptional control in keratinocytes and fibroblasts using synthetic ligands
... that synthetic ligands could direct this system of gene expression in kerati- nocytes and fibroblasts, we wished to determine if this system would allow control of the magnitude of gene expression in a ...
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Insilico Identification of Novel Inhibitors for Shikimate Kinase from Mycobacterium Tuberculosis using Natural and Synthetic Ligands
... the ligands Digoxigenin (Natural ligand) which formed a complex hydrogen bond with LEU15, SER16 and ARG117 showed the lowest binding energy of ...the synthetic ligands compound with ZINC02838601 ...
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Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels
... peptidic ligands and DR5 at the membrane ...between synthetic ligands and DR5 is crucial and will be helpful for the development of efficient multivalent ...oligomerized synthetic ...
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Structural Basis of DNA Recognition by Synthetic Ligands
... The DNA double helix presents functional groups in the major and minor grooves that can be used by ligands for readout of the base pair sequence.. The overall flexibility and shape also [r] ...
160
Polymers for binding of the gram positive oral pathogen Streptococcus mutans
... of synthetic polyvalent ligands—with either cationic/ zwitterion or carbohydrate binding units—and tested them for their ability to bind selectively the pathogenic ...polymer ligands were varied to ...
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Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice
... We previously reported on a novel viral vaccine adjuvant that is comprised of two synthetic ligands for Toll-like receptor 4 (TLR4) and TLR7 (18). 1Z105 is a substituted pyrimido[5,4-b]indole compound ...
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016_2009.pdf
... Understanding how discreet tissues and neuronal circuits function in relation to the whole organism to regulate physiological processes and behaviors is a fundamental goal of modern biological science. Powerful and ...
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Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses
... small synthetic ligands for innate immune recep- tors as vaccine adjuvants is an attractive way to simultaneously address the often competing needs of efficacy and ...
15
PubMedCentral-PMC4759656.pdf
... chemogenetic technologies can be harnessed in neuroscience. Thus, for instance, a major concern for chemogenetic technologies is the possibility that high levels of expression of an engineered protein might have effects ...
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Rosiglitazone Attenuates Insulin-Like Growth Factor 1 Receptor Survival Signaling in PC-3 Cells
... and synthetic ligands of PPAR γ via genomic and nongenomic actions promote cell cycle arrest and apoptosis of several prostate can- cer cells, in ...γ ligands,15dPGJ2 and rosiglitazone, a natural and ...
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Retinoid activation of retinoic acid receptors but not of retinoid X receptors promotes cellular differentiation and replication of human cytomegalovirus in embryonal cells.
... novel synthetic ligands specific for either RARs or RXRs, what ligand interaction is physiological in the retinoid receptor pathways necessary for inducing replication of hCMV in differentiated embryonal ...
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1-s2.0-S0092867419311262-main.pdf
... To identify all human genome encoded peptides, we extracted the human proteome annotation from UniProtKB/Swiss-Prot (version 2018.3; released 28/03/2018) and searched for all PEPTIDE annotations. This led to a unique set ...
36
Estrogens of multiple classes and their role in mental health disease mechanisms
... estrogenic ligands; these ligands and their effects vary with life stages, the genetic or postgenetic regulation of receptor levels in specific tissues, or the intercession of competing nonphysiological ...
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Theoretical design and development of catalyst systems
... Comparison of carbonylation of neutral and cationic alkyl-palladium complexes of bidentate N-O ligands has demonstrated that the dependence of the experimental rate on the ligands is not[r] ...
222
Blueprints of Signaling Interactions between Pattern Recognition Receptors: Implications for the Design of Vaccine Adjuvants
... the ligands (A and B) used to stimulate the PBMCs are depicted; PBMCs were stimulated with either a single ligand or a combination of two PRR ...both ligands combined should be higher than the combined ...
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PROTEIN LIGAND DOCKING: A MINI REVIEW WITH A CASE STUDY
... of ligands type for docking is mainly depends on the aim of ...pharmacophores, synthetic accessibility, and absorption, distribution of molecules, metabolism, excretion, and toxicology characteristics, ...
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In silico analysis to compare the effectiveness of assorted drugs prescribed for swine flu in diverse medicine systems
... the ligands fall within the proposed limit confirming their drug likeness, except zanamivir and vitamin E (Table ...the ligands was found to be 1 except for zanamivir and vitamin E showing 0, which further ...
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Organometallic Complexes as Ligands
... This work is protected against unauthorized copying under Title 17, United States C o d e M icroform Edition © ProQuest LLC.. ProQuest LLC.[r] ...
211
Integrins and their ligands in rheumatoid arthritis
... Migration, invasion, and proliferation of synovial cells are major problems in rheumatoid arthritis (RA) [3]. Th is debilitating disease is characterized by an infl amed synovial tissue with a massive infl ux of immune ...
8
Salicylic Acid-Formaldehyde Oligomer-Thermogravimetric Analysis [TGA]
... cause decarboxylation as reported by Parekh The calculated value of CO ligands and % loss of first stage degradation of each ligands are presented in 2.3.Examination of these data reveals that the ...
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