T-Cell Antigen Receptors
Disulfide linked gamma delta T cell antigen receptors expressed on T cells derived from patients with primary immunodeficiency disorders
... T cell lines or clones from two patients, one with a partial DiGeorge syndrome and one with severe common variable immunodeficiency expressed disulfide-linked gamma delta T cell antigen ...
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ITAMs versus ITIMs: striking a balance during cell regulation
... B cell and T cell antigen receptors, and the Fc ε RI receptor shared a sequence motif now known as an ITAM (1, 2), a sequence pos- tulated to link antigenic receptors to their ...
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Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia
... of T cells and avoid apoptosis by promoting the IL-2 syn- ...CAR T cells primarily caused consti- tutive stimulation, proliferation and ...CAR T cells induced early exhaustion, thereby limiting the ...
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A phase I clinical trial of adoptive T cell therapy using IL 12 secreting MUC 16ecto directed chimeric antigen receptors for recurrent ovarian cancer
... 4H11-28z/fIL-12/EFGRt T cells will be assessed by RT-PCR analysis and by FACS at different time points, as described below, where we will obtain cell numbers and percentages of CAR T cells compared ...
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Effective NY ESO 1–specific MHC II–restricted T cell receptors from antigen negative hosts enhance tumor regression
... of T cell receptor–engineered (TCR-engineered) T cells is a promising approach in cancer therapy but needs improvement for more effective treatment of solid ...+ T cells, the importance of CD4 ...
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Chimeric antigen receptor T cell therapies for multiple myeloma
... Antibody-dependent cell-mediated cytotoxicity; AE: Adverse event; ALL: Acute lymphocytic leukemia; APRIL: A proliferation-inducing ligand; ASCO: American Society Clinical Oncology; ASCT: Autologous stem ...
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Single-cell analysis of glandular T cell receptors in Sjögren’s syndrome
... of antigen-driv- en proliferation in the SG (Figure ...SG T cells as well as some single T cells within individuals and across unrelated individuals, particularly for TCRβ (Figures 6 and ...SG ...
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Role of persistent CMV infection in configuring T cell immunity in the elderly
... non-adapted T cell response to stimulation. Many age-associated changes in T cell phenotype and function are caused by the process of senescence ...virgin antigen-non experienced ...
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Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells
... measure T cell alloreactivity is imprecise and non-quantitative, as it involves functional MLRs with large banks of haplotyped ...FlowPRT cell assay revealed a direct correlation between the relative ...
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Car Drivers and Fuel Sources: How Distinct Signaling Domains in Chimeric Antigen Receptors Reprogram T Cells
... Thus far, over a 100 patients with CD19+ hematological malignancies have been treated with the anti-CD19 CAR T cells. The impressive clinical results have demonstrated that adoptive cell therapy with ...
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Characterisation of and T cell responses to the P91A tumour minus antigen.
... the T cell receptors used by transgenic and non-transgenic T cell clones two complementary rtPCR approaches were ...selected T cell clones, figure ...the T ...
326
Application of in vivomicroscopy: evaluating the immune response in living animals
... T cell–DC interaction in the absence of specific antigen In the absence of specific antigen, T cells were found to migrate autonomously in the T cell area and B cells ...
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Fc γ receptors and the complement system in T cell activation
... mediated antigen-presentation to CD4 + T cells directly in vivo, wild-type and CD11c-DTR transgenic mice were injected with CFSE-labelled OVA-specific CD4 + T cells and immunized with ...induces ...
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Molecular analysis of T cell receptors: Mapping T cell recognition and repertoire in two human immune responses
... Th cell, and th at the presence of p articular cytokines w hen antigen is first encountered influences which type of Th cell is produced (Hsieh et al, ...to T hl ...by T h l cells, ...
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Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors
... + T cells were isolated from healthy donor blood samples obtained from the Boston Children’s Hospital Blood Donor Center and the UCLA Blood & Platelet ...Human T-cell Enrichment Cocktail ...
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Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies
... CAR-T cell treat- ment, namely whether they have toxic effects and whether CAR-T cells are sustainable, have hindered its broad clinical ...effector T cells and the design of CARs must be ...
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Scavenger receptors target glycolipids for natural killer T cell activation
... NKT cell agonist digalac- tosylceramide critically depends on its apoE-mediated uptake via the LDLR ...different receptors, including the LDLR, SRA, SRB1, and ...lipid antigen rather than by the ...
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The effect of autologous tumour vaccine on benzo a pyrene induced squamous cell carcinoma of skin in mice
... Analysing T cell receptors TCR of the lymphocytes infiltrating regressive melanoma revealed that there is clonal expansion of TIL which display MHC antigen-restricted cytotoxic activity [r] ...
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Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies
... two T cell acute lymphoblastic leukaemia (T-ALL) cell lines (CML-T1 and RPMI8402), with confirmed FBXW7 ...to T cell-tumor cell co-culture, some tumor cells were ...
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New advances in leukaemia immunotherapy by the use of Chimeric Artificial Antigen Receptors (CARs): state of the art and perspectives for the near future
... with T cells using unmanipulated donor lymphocyte infusion (DLI) for the treatment of leukaemia recurrence in Haematological Stem Cells Transplantation (HSCT) recipients has shown some positive results in AML, but ...
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