T-cell based immunotherapy
T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy
... in T cells, we determined the potential role of a decreased mTOR signaling in this ...stimulated T cells to those levels found in T cells treated with mTOR inhibitor rapamycin (Figure ...activated ...
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miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy
... CAR, based on the monoclonal antibody cetuximab, is less efficient in target- ing EGFR-expressing tumor cells than EGFRvIII-positive cells ...CAR T cells expressing this CAR transgene demonstrate stronger ...
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Immunotherapy with Allergen Peptides
... peptide immunotherapy has been shown to improve clinical outcomes and surrogate markers in a variety of ...of T-cell epitopes without competent B-cell epitopes will be sufficient to provide ...
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The generation of cytotoxic T cell epitopes and their generation for cancer immunotherapy
... regulatory T cell responses, and, as elaborated in this thesis, (4) an ap- propriate multipotent target choice, will help to improve vaccine ...adoptive T cell transfer is an important im- ...
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The current status of immunobased therapies for metastatic renal-cell carcinoma
... CD4 T-cell-mediated ...such immunotherapy approach using mature monocyte-derived DCs, patient tumor RNA, and synthetic CD154 RNA to induce a potent patient-specific antitumor T-cell ...
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An Optogenetic Controllable T Cell System for Hepatocellular Carcinoma Immunotherapy
... extend T cell’s tumor cell killing ability beyond traditional antigen-activated T cell killing pathways, T cells could be engineered to secrete or carry additional molecules that could ...
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Evaluation of basophil activation caused by transgenic rice seeds expressing whole T cell epitopes of the major Japanese cedar pollen allergens
... of immunotherapy. Oral immunotherapy with the trans- genic rice might improve treatment adherence because rice is a principal food of the ...to immunotherapy could cir- cumvent the problems ...
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<p>Past, Present, and Future of Anticancer Nanomedicine</p>
... stem cell-based therapies have been ...stem cell-based therapies have limitations that make them inadequate for clinical ...cancer immunotherapy, especially T ...
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Expression of tumor antigens on primary ovarian cancer cells compared to established ovarian cancer cell lines
... cancer immunotherapy of the ovarian ...cancer cell lines selected in our study as the most suitable for DC- based immunotherapy protocols of high-grade ovarian cancer, namely OV-90 and ...
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Newly identified T cell subsets in mechanistic studies of food immunotherapy
... immune cell populations (33, ...and cell-surface targets in a single sampling of cells by labeling with metal isotypes rather than fluorochromes ...memory T cells and Tregs compared with healthy ...
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New therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota
... and T lymphocyte attenuator; CAF: cancer associated fibroblasts; CEA: carcinoembryonic antigen; CSC: cancer stem cell; CSCC: cutaneous squamous cell carcinoma; CT: cytoplasmic tail; CTLA-4: cytotoxic ...
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Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy
... from Cell Signaling ...of T cells for intracellular cytokine staining was accomplished using Leukocyte Activation Cocktail containing phorbol myristate acetate and ionomycin in combination with brefeldin A ...
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Utilizing the adjuvant properties of CD1d dependent NK T cells in T cell–mediated immunotherapy
... antigen-specific T cells without the confounding effect of neu- tralizing responses directed at the vector itself ...prime T cells, and recombinant vaccinia viral vectors were used to “boost” the induced ...
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Identification of Hexon-Specific CD4 and CD8 T-Cell Epitopes for Vaccine and Immunotherapy
... ⫹ T-cell epitopes has previously been described for the tumor setting where MART-1-specific CD8 ⫹ T cells recognize the HLA-A2- restricted peptide EAA (aa 26 to 35), which has direct se- quence ...
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T regulatory Cell-mediated Immunotherapy for Solid Organ Transplantation: A Clinical Perspective
... conventional T cells ...regulatory T cells play a pivotal role in maintaining ho- meostasis and self-tolerance through the modulation of immune effector functions ...and based on these observations, ...
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Therapeutic cancer vaccines
... tumoricidal T lymphocytes, but the T cell repertoires available against these antigens must be carefully ...the T cell repertoire against these is usually blunted and because powerful ...
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Advances in T-cell checkpoint immunotherapy for head and neck squamous cell carcinoma
... trials. Based on intriguing preclinical data from many groups, several ongoing clinical trials (Table 1) are investigating the role of immune checkpoint blockades in R/M HNSCC including single agent and ...
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Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions
... pan T cell marker comprised of four distinct polypeptide chains, epsilon, gamma, delta, and zeta, which form pairs of dimers, transmitting T cell activa- tion ...on T cells, it has been ...
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Designing T-cells with desired T-cell receptor make-up for immunotherapy
... low cell surface expression after TCR gene transfer were aligned and differences in nucleotide sequences were ...TCR cell surface expression was analyzed for the eGFP/NGF-R double positive J76 ...
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Prophylactic and therapeutic adenoviral vector-based multivirus-specific T-cell immunotherapy for transplant patients
... virus-specific T-cells in a single step. Ad-MvP encodes 32 CD8+ T-cell epitopes from cytomegalovirus, Epstein-Barr virus, adenovirus, and BK virus as a contiguous ...multivirus-specific ...
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