T-cell epitope
Pathogenic Potential of Borna Disease Virus Lacking the Immunodominant CD8 T-Cell Epitope
... the epitope TELEISSI located in the viral nucleo- protein N, we generated BDV mutants that feature TQLEISSI in place of ...CD8 T cells induced neurological disease in ...CD8 T-cell ...
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Cloning, expression and T cell epitope prediction of fbpA and fbpB genes of Mycobacterium tuberculosis clinical isolates
... and T-cell epitope prediction of fbpA and fbpB genes from clinical ...The T-cell epitope prediction was analyzed by GENETYX vers ...specific T-cell epitopes based ...
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Characterization of T-cell response to woodchuck hepatitis virus core protein and protection of woodchucks from infection by immunization with peptides containing a T-cell epitope.
... of T cells appears to be a prerequisite for viral clearance during hepatitis B virus (HBV) ...The T-cell response to HBV core protein is essential in determining an acute or chronic outcome of HBV ...
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T Cell Epitope Clustering in the Highly Immunogenic BZLF1 Antigen of Epstein-Barr Virus
... ⫹ T cell epitopes while other areas are not targeted at all? One pos- sibility is that sequence similarity with human protein sequences results in immune tolerance to parts of the BZLF1 ...of epitope ...
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Loss of Immunization-Induced Epitope-Specific CD4 T-Cell Response following Anaplasma marginale Infection Requires Presence of the T-Cell Epitope on the Pathogen and Is Not Associated with an Increase in Lymphocytes Expressing Known Regulatory Cell Phenotypes
... CD4 T-cell response to the A. marginale immunogen. Furthermore, T-cell responses following infection in nonimmunized cattle had a delayed onset and were sporadic and transient during ...
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Identification of a T-cell epitope adjacent to neutralization antigenic site 1 of poliovirus type 1.
... Immunization of BALB/c H-2d mice with the uncoupled p86-115 peptide, which represents VP1 amino acids 86 to 115 and contains both the T-cell epitope and the C3 neutralization epitope, in[r] ...
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T Cell Epitope Mapping of JC Polyoma Virus-Encoded Proteome Reveals Reduced T Cell Responses in HLA-DRB1*04:01+ Donors
... Large T antigen (LTAg, dark blue arrow), small T antigen (STAg, light blue arrow), three additional alternative splice variants of the large T antigen (T=135, T=136, and T=165, ...
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Identification of a T cell epitope in the Staphylococcus aureus Panton Valentine LukS PV component
... challenged with peptides 7 (149 - 173), 8 (169 - 193) or 14 (289 - 312) elicited significant responses compared to footpad swelling measurements observed following challenge with the remaining peptides, however, re- ...
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Three-Dimensional Structure Determines the Pattern of CD4+ T-Cell Epitope Dominance in Influenza Virus Hemagglutinin
... of T-cell lines or clones from nine allergic patients reported by Schenk et ...10. Epitope scores were assigned to residues according to the number of patients whose lines or clones responded to the ...
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Immunodominant T-cell epitope on the F protein of respiratory syncytial virus recognized by human lymphocytes.
... Strikingly, the lymphocytes of all 4 donors responded primarily to a region defined by a single peptide spanning residues 338 to 355, and the lymphocytes of 2 donors responded to an over[r] ...
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Influenza T-cell Epitope-Loaded Virosomes Adjuvanted with CpG as a Potential Influenza Vaccine
... these antibodies are usually not cross-reactive, they do provide protection against homologous influenza strains. Thus, in case the circulating virus matches the source influenza strain of the virosomes, additional ...
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Identification of the Immunodominant H-2Kk-Restricted Cytotoxic T-Cell Epitope in the Borna Disease Virus Nucleoprotein
... We mapped the CTL epitope in BDV p40 by two comple- mentary experimental approaches. In a first approach, we gen- erated C-terminally truncated versions of p40 that were sub- sequently introduced into recombinant ...
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Arthritogenic T cell epitope in glucose 6 phosphate isomerase induced arthritis
... bovine (type II collagen) CII 256–270 (GEPGIAGFKGEQGPK), the dominant epitope of collagen-induced arthritis (CIA), at the major histocompatibility complex (MHC) binding sites [4]. Of note is that arthritis similar ...
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Fine structure of a virus-encoded helper T-cell epitope expressed on FBL-3 tumor cells.
... To understand peptide-major histocompatibility complex MHC interactions and the subsequent recognition of peptides by specific T cells, we used peptides of decreasing lengths to determin[r] ...
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Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein.
... The aim of the present study was to identify the minimal optimal sequence recognized by HBcAg1ll27-specific CTLs in order to more thoroughly characterize the CTL response to this epitope[r] ...
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Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope.
... Spleen cells from mice primed with the recombinant vaccinia virus MCMV-ieI-VAC, encoding pp89 left panel, or with the recombinant AS-mer, encoding a deletion mutant of pp89 that lacks th[r] ...
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Presentation of an immunodominant T-cell epitope of hepatitis B surface antigen by the HLA-DPw4 molecule.
... Antibody DA6.231, with broad specificity for DR and DP, and antibody B7/21, specific for DP antigens, were tested for their capacity to inhibit the proliferative response of the HBsAg-sp[r] ...
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Three dimensional structure directs T-cell epitope dominance associated with allergy
... CD4+ epitope immunogenicity on local structural context has been examined for a number of epitopes and ...antigens. Epitope presentation often may depend on an initial proteolytic-processing ...an ...
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IN-SILICO T-CELL EPITOPE PREDICTION TOOL OF HEPATITIS C VIRUS (HCV)
... the T-Cell epitopes of HCV, the protein sequence of hepatitis C virus (HCV) is retrieved from research papers (15-33) via pubMed-NCBI ...the T-cell epitopes of HCV differs ranging from six ...
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Engineering T Cells Specific for a Dominant Severe Acute Respiratory Syndrome Coronavirus CD8 T Cell Epitope
... TCR-redirected T cells dis- play a similar polyfunctional profile compared to SARS-spe- cific memory CD8 T ...TCR-redirected T cells specific for NP44 (aa 216 to 225) were engineered from PBMC of ...
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