T cell receptor
Original Article Detection of immunoglobulin and T-cell receptor gene rearrangements in angioimmunoblastic T-cell lymphoma
... and T-cell receptor gene rearrangements in the diagno- sis and differential diagnosis of angioimmunoblastic T-cell ...munoblastic T-cell lymphoma confirmed by ...
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Immunodominance of a low affinity major histocompatibility complex binding myelin basic protein epitope (residues 111 129) in HLA DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire
... and T cell receptor us- age (43–45), although an association of the immunodominant central epitope of MBP(87–106, 81–99) to the DR2 haplotype has been consistently reported (3–5, 46, ...
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Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1
... ⫹ T-cell response depends on the arsenal of T-cell receptor (TCR) clonotypes deployed to engage the targeted peptide-human leukocyte antigen class I (pHLA-I) ...⫹ T-cell ...
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Isolation of T cell receptor specifically reactive with autologous tumour cells from tumour-infiltrating lymphocytes and construction of T cell receptor engineered T cells for esophageal squamous cell carcinoma
... Background: T cell receptor-engineered T cells (TCR-Ts) therapy is a promising cancer treatment ...high-avidity T cell receptors (TCRs) directed against neoantigens derived from ...
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MaGiK Method of T-Cell Receptor Repertoire Analysis
... through T-cell receptor (TCR) recognition of for- eign peptides presented by human leukocyte antigens (HLA) ...of T cells is a heterodimer consisting of an ␣- and a -polypeptide chain ...of ...
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T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia
... gamma-T cell receptor (TCR) gene activation within acute lymphoblastic leukemias (ALLs) that represent early stages of B and T cell ...
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High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata
... High-throughput T cell receptor sequencing has transformed our ability to conduct a global assessment of the T cell receptor diversity in blood and in any given organ or ...
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T cell receptor independent immunosuppression induced by dexamethasone in murine T helper cells
... The immune and inflammatory responses are largely inhibited by glucocorticosteroids. In thymocytes, for example, glucocorticosteroids cause apoptosis, whereas they suppress the activity of phospholipase A2 and the ...
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T cell receptor repertoire of infiltrating T cells in lips of Sjögren's syndrome patients
... Infiltrating T cells around salivary glands in the lips of Sjögren's syndrome (SjS) patients are crucial in the pathogenesis of this ...infiltrating T cells, their T cell receptor ...
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T cell receptor alpha chain gene rearrangements in B precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia Comparative study of T cell receptor gene rearrangement in childhood leukemia
... analyzed T cell receptor alpha-chain gene configuration using three genomic joining (J) region probes in 64 children with acute lymphoblastic leukemia ...18 T-ALLs were T3 positive; ...
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T cell receptor-engineered T cells for leukemia immunotherapy
... antigen receptor; TCR : T cell receptor; CD19: cluster of differentiation 19; HLA: human lymphocyte antigen; MART-1: melanoma-associated antigen pep- tide-1; WT1: Wilms’ tumor gene product 1; ...
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Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance
... of T cell activation, but the effect of HIV antigen reduction on the T cell receptor (TCR) repertoire of epitope-specific T cell responses remains poorly defined ...
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Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium
... CD4+ T lymphocytes, and a genetic linkage to the MHC antigen HLA-DR4. Since T cells are restricted by class II MHC molecules such as DR4, this suggests a direct role for these CD4+ cells in ...investigate ...
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The Effect of T Cell Receptor Specificity on CD4+CD25+ Regulatory T Cell Function in an Autoimmune Setting
... + T cells that have been injected systemically can be found in the draining lymph node, synovial fluid, and synovial tissue as early as one day post transfer, indicating that the cells are trafficking to the ...
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T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
... ⫹ T-cells Exhibit Substantial Diversity in Their Ability to Recognize Natural Tumor Epitopes—It is established that the ELAGIGILTV and EAAGIGILTV peptides exhibit differential binding to HLA A*0201 (34, ...higher ...
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Downregulation of the T-Cell Receptor Complex and Impairment of T-Cell Activation by Human Herpesvirus 6 U24 Protein
... Human herpesvirus 6 (HHV-6) is a ubiquitous pathogen of the betaherpesvirus family, which includes cytomegalovirus and HHV-7, that primarily infects CD4 ⫹ T cells (26, 38). Like other herpesviruses, HHV-6 ...
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Virus-specific CD8+ T-cell responses in mice transgenic for a T-cell receptor beta chain selected at random.
... Depletion of the CD4+ T-cell subset had little effect on the course of influenza virus infection but substantially slowed the development of the Sendai virus-specific CTL response and vi[r] ...
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Comparison of T cell receptor alpha, beta, and gamma gene rearrangement and expression in T cell acute lymphoblastic leukemia
... leukemic T cell lines (HSB2, CEM, and ...the T cell lines. All T-ALL and the three T cell lines exhibited both TCR-gamma and beta gene ...10 T-ALL and all T ...
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HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation
... CD4 T cell activation, as measured by CD69 upregulation and IL-2 secretion, and induced a greater level of CD4 T cell ...CD4 T cell activation. In contrast, the interaction of ...
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T cell receptor signaling for γδT cell development
... The TCR is a complex receptor that consists of receptor subunits (TCRαβ or γδ) and CD3 subunits (CD3γ, δ, ε, and ζ) [16]. TCR signal transduction involves the conform- ational change, as well as the ...
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