T cell-stimulatory capacity
Bordetella adenylate cyclase toxin differentially modulates toll like receptor stimulated activation, migration and T cell stimulatory capacity of dendritic cells
... of cell adhesive contacts and migration of DCs towards the lymph node-homing chemokines CCL19 and CCL21 in ...the capacity of toxin-treated DCs to induce CD4 + and CD8 + T cell ...the ...
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Mature Dendritic Cells Infected with Herpes Simplex Virus Type 1 Exhibit Inhibited T-Cell Stimulatory Capacity
... Here we report that HSV-1-infected mature DC are inhib- ited in their T-cell-stimulatory capacity. Furthermore, we show that mature DC do not generate infectious virus particles. On the ...
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Phenotypic and functional analysis of monocyte populations in cattle peripheral blood identifies a subset with high endocytic and allogeneic T-cell stimulatory capacity
... Circulating monocytes in several mammalian species can be subdivided into functionally distinct subpopulations based on differential expression of surface molecules. We confirm that bovine monocytes express CD172a and ...
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Human major group rhinoviruses downmodulate the accessory function of monocytes by inducing IL 10
... the T-cell stimulatory capacity of ...proliferative T-cell response induced by allogeneic monocytes (Figure ...allostimulatory capacity of md-DCs was also strongly ...
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Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB
... their T cell stimulatory ...+ T cells, and both T cell proliferation and the cytokine pattern in DC/T cell cocultures were ...genic T cell ...
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A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function
... their capacity to enhance a TCR-driven antigen specific ...primary T- cells transduced to express a TIGIT-28 chimera (TM TIGIT or TM28) along with the F4 TCR were co-cultured with several melanoma ...
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Blockade ofthe negative co stimulatory molecules PD 1 and CTLA 4 improves survival in primary and secondary fungal sepsis
... increased T regulatory cells, increased myeloid derived suppressor cells, and apoptosis-induced depletion of immune effector cells, recent studies highlight the likely role of PD-1 mediated T cell “ ...
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Original Article CD11c antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation
... of T cell activation but only plays a minor role in fine-tuning T cell immunity [6, ...cytotoxic T-lym- phocyte reactions against viral infections ...TCR-mediated T cell ...
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Original Article Hepatitis B virus e antigen (HBeAg) may have a negative effect on dendrtic cells maturation
... important cell surface molecules, another feature of DCs is their ability to promote T-cell ...this capacity of HBeAg-treated DCs. A clearly reduced T-cell proliferation compared ...
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Minimal T-Cell-Stimulatory Sequences and Spectrum of HLA Restriction of Immunodominant CD4+ T-Cell Epitopes within Hepatitis C Virus NS3 and NS4 Proteins
... ⴙ T-cell ...⫹ T-cell clones were first tested against the com- plete set of truncated variants at high peptide concentrations (10 ...where stimulatory capacity was lost were ...
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Three day dendritic cells for vaccine development: Antigen uptake, processing and presentation
... mulatory capacity for ...stimulate T cells ...the stimulatory capacities of 3d and 7d mDC side-by-side after electroporation of MART-1/Melan-A ...diminished stimulatory capacity ...
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T cells from patients with Candida sepsis display a suppressive immunophenotype
... Increased T cell PD-1 expression occurs under condi- tions of chronic antigenic stimulation, such as persistent viral infections, and leads to T cell exhaustion ...exhausted T cells are ...
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Targeting peripheral blood pro-inflammatory cytotoxic lymphocytes by inhibiting CD137 expression: novel potential treatment for COPD
... Expression of CD137 was determination as previously re- ported for T cells [5]. Briefly, at 16 h 100 μL 20 mM EDTA/PBS was added to the culture tubes which were vortexed vigorously for 20 sec to remove adherent ...
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Development of TaqMan probes targeting the four major celiac disease epitopes found in α-gliadin sequences of spelt (Triticum aestivum ssp. spelta) and bread wheat (Triticum aestivum ssp. aestivum)
... Different strategies are currently being investigated to address the CD problem, such as gluten detoxification, modulation of mucosal permeability, antigen presenta- tion blockade, raising monoclonal antibodies against ...
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T cell co stimulatory pathways in autoimmunity
... CD28 is a separate signaling unit, independent of the TCR activation complex, which is very much in line with the two- signal hypothesis. Initially, it was thought that each of these two signaling pathways would be ...
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Growth, Yield and Economics of Broccoli (Brassica oleracea var. Italica) as Influenced by Organic and Inorganic Nutrients
... The present result revealed that the plant height in broccoli crop was influenced by the combined application of NPK and Biofertilizer along with different organic sources. Application of 100% chemical fertilizer alone ...
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Identification of an immunogenic 18 kDa protein of Helicobacter pylori using alkaline phosphatase gene fusions : a thesis presented in partial fulfillment of the requirement for the Doctor of Philosophy in Molecular Microbiology, Massey University, Palmerston North, NZ
... unstable cell envelope proteins (Strauch and Beckwith, 1 988; Baneynx and Georgiou, 1 ...known cell envelope pro teases such as DegP can therefore permit the selection of a suitable host based on reduced ...
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Impact of nanoparticles on neuron biology: current research trends
... Despite having therapeutic potentials, nanoparticles pose safety concerns. There are few nanoparticles, which are also reported to have inhibitory effects on the neuronal cells. These nanoparticles caused opposite and ...
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Inhibition of soluble antigen induced T cell proliferation by warm reactive antibodies to activated T cells in systemic lupus erythematosus
... resting T cells, which exhibited little inhibitory ...responding T cell, which markedly reduced the expression of receptors for interleukin ...on T cells already committed ...
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Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself
... digestion buffer or control agarose beads under identical conditions. The silver stain gel in Figure 2A shows that the fully intact 70 kD HSP70 protein was digested by the Proteinase K-agarose treatment, and that under ...
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