T-cell tolerance induction
Review Article The role of butyrate in peripheral regulatory T cell and tolerance induction
... of cell types and dis- ease ...the tolerance-inducing effect of ...activated T cells and induction of peripheral Tregs, butyrate derivatives could be more effective immune regulators as ...
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Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance
... responding T cell pool? Clearly, regulatory mechanisms evolve normally in the course of immune responses and are critical to prevent autoimmunity ...al tolerance strategies, presumably to neutralize ...
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Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer
... or tolerance, with tolerance being the most like- ly outcome at high expression ...of tolerance induction can be corre- lated with levels of transgene expression, which are high- er in C57BL/6 ...
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Exogenous IL-33 overcomes T cell tolerance in murine acute myeloid leukemia
... activate T cells is determined by their maturation ...peripheral tolerance to ...leukemia-reactive T cells [5, 10]. The net effect is the induction of peripheral T cell ...
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The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
... Autoreactive T cells are generally eliminated by negative selec- tion during thymic development (central ...peripheral tolerance remain largely unknown, progress has been made that sheds light on how TCR ...
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Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current Concepts
... stable cell numbers, with distinct population ratios, and with a proper localization within distinct anatomical com- ...affecting T cell numbers and functions, such as seen for example dramatically ...
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Characterising negative regulation of CD8+ T cell function in tolerance and exhaustion
... + T cells early during the response, although the cells ultimately become committed to an exhausted fate at later time-points ...both tolerance and ...why tolerance induction to steady-state ...
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CD40 ligation reverses T cell tolerance in acute myeloid leukemia
... antigen-specific T cell response induced by ...rapid induction of periph- eral tolerance. This tolerance appeared to be due to the intrinsic dysfunction and deletion of antitumor ...
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Wang, Lei (2017): Mechanisms of central and peripheral T cell tolerance to an antigen of the central nervous system. Dissertation, LMU München: Medizinische Fakultät
... Anergic T cells are characterized by a variety of functional limitations, including cell differentiation, cell division and cytokine ...+ T cells can be induced through TCR ligation in the ...
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Induction of Immunological Tolerance to Adenoviral Vectors by Using a Novel Dendritic Cell-Based Strategy
... purified CD4 ⫹ and CD8 ⫹ T cells (21). IL-10 has been further shown to inhibit upregulation of CD86 on DCs. Addition of IL-10 to in vitro cultures of skin-derived dermal DCs resulted in signif- icant reduction of ...
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T helper cell mediated-tolerance towards fetal allograft in successful pregnancy
... in rejecting allografts [13], indicating that some Th1- dependent effector mechanisms play a central role in acute allograft rejection of transplanted tissues [14]. On the other hand, the production of the Th2-type ...
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Studies of tolerance induction in B lymphocytes
... B cell proliferation, and require helper signals for their clonal expansion and further ...helper T cells (Th), and includes both contact-mediated signals and cytokines (reviewed in Parker, ...that T ...
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Challenges to achieving clinical transplantation tolerance
... of T cell costimulatory block- ade (27, 28) or T cell depleting agents (29, ...CD154 T cell costimulatory blockade strategies to the clinic (10, 31, ...the induction or ...
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In situ characterisation of CD4+ t cell behaviour in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance
... of cell clustering is ex- pected to occur purely due to random collisions between free-moving cells, with the number of such clusters increas- ing with cell ...given cell densities, average ...
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Heterologous immunity provides a potent barrier to transplantation tolerance
... many tolerance strategies, such as regimens employing T cell costimula- tion blockade, successfully target and control naive T cell responses, memory cells have a lower threshold for ...
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Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity
... concomitant induction of cytotoxic T lymphocytes (CTLs), and indeed, mucosal administration of the model antigen ovalbumin (OVA) has been shown to elicit CTL activation while simultaneously inducing oral ...
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Antibody enhanced cross presentation of self antigen breaks T cell tolerance
... Anti-OVA IgG enhances functional antigen presentation in the pan- creatic lymph node. (A) OT-I cell proliferative responses. Pancreatic lymph node cells isolated from RIP-mOVA mice 3 days after transfer of ...
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Gene Therapy Approaches To Immune Tolerance Induction In Canine Hemophilia
... first described when it was observed that frequent administration of large doses of FVIII could reduce inhibitor titers over time 91 . Currently, there are many variations of ITI, but they all have in common continuous ...
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Identification of Notch1 as a Frequent Target for Provirus Insertional Mutagenesis in T-Cell Lymphomas Induced by Leukemogenic Mutants of Mouse Mammary Tumor Virus
... FIG. 2. Schematic representation of the proviruses integrated within the Notch1 gene in MLA-MMTV-induced T-cell lymphomas. (A) Rearranged regions of the Notch1 genome are shown together with a schematic ...
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Induction of B cell apoptosis by TH0, but not TH2, CD4+ T cells
... the T cell receptor molecules with MHC-antigen complexes presented by B cells ascertains antigen specificity in T cell-dependent ...antigen-specific T-B cell interaction, but has ...
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