T-type calcium channels
Antagonism of T type calcium channels inhibits high fat diet–induced weight gain in mice
... of T-type calcium channels, TTA-A2, to normal-weight animals prior to the inactive phase acutely increased sleep, decreased body core temperature, and prevented high-fat diet–induced weight ...
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Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing
... administration. T-type calcium channels are implicated in the generation of sleep rhythms and in this study we examined whether a Heantos-4 extraction modulates T-type ...
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T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B
... T-type calcium channels are important regulators of neuronal excitability and low threshold-mediated exocyt- osis [1, ...different T-type calcium channels ...these ...
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Neuroprotective effects of blockers for T-type calcium channels
... gated calcium channels have been implicated in playing a role in neuronal death during aging ...Though T- type calcium current increases with age [35], to our knowledge the role of ...
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Block of T-type calcium channels by protoxins I and II
... wild type channel, whereas constructs that contained ...wild type Cav3.3 channels [Figure ...on T- type calcium ...wild type channels, although two con- structs ...
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Current and emerging “at-site” pain medications: a review
... ion channels (sodium channels, T-type calcium channels, P2X receptors, TRP channels), peptide receptor antagonists, NGF and glial cell modulators to treat nociceptive, ...
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G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membrane
... Various calcium channel blockers, including the T-type voltage-gated calcium channel inhibitor flunarizine dihy- drochloride (FL), L-type calcium channel inhibitor verap- amil ...
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Calcium as a second messenger in developing nerve cells
... L type calcium channels^ as T type calcium channels are inactivated at a holding potential of -40 mV (Silver et ...
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Role of Inositol 1, 4, 5-Triphosphate on Heart Rate in Isolated Heart Models of Wistar Rats
... nucleotide-gated) channels which produces an inward current called the funny ...the T-type calcium channels get activated and produce more ...The calcium ions entering the cell ...
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Scanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition
... Neither of the latter Val 416 substitutions resulted in sig- nificant changes in PPF ratio as compared to WT chan- nels, Fig. 2A). However, the phenylalanine substitution at Arg 376 significantly increased the PPF ratio ...
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Ionic selectivity in L-type calcium channels by electrostatics and hard-core repulsion
... of the model pore and the baths. When a small driving force is applied between the flat surfaces of the cylinder, the local pertur- bations of the chemical potential with regard to the uniform chem- ical potential ...
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2DQSAR of novel 1,4 dihydropyridine derivative blocking n type calcium channels
... [3]. Saegusa, H.; Kurihara, T.; Zong, S.; Kazuno, A.; Matsuda, Y.; Nonaka, T.; Han, W.; Toriyama, H.; Tanabe, T. EMBO J. 2001, 20, 2349; (b) Takizawa, S.; Matsushima, K.; Fujita, H.; Nanri, K.; ...
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Are ryanodine receptors important for diastolic depolarization in heart?
... ion channels causing current known as funny currents (I f ...current. T type calcium channel open at this potential and more depolarization of membrane ...This calcium entry via ...
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Expression of calcium channel transcripts in the zebrafish heart: dominance of T type channels
... ion channels, human stem cell-induced cardiomyocytes and in silico models of human cardiac AP are considered acceptable for drug screening and safety pharmacology (Gintant et ...ion channels (Colatsky et ...
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Characterization and bioactivity of novel calcium antagonists - N -methoxy-benzyl haloperidol quaternary ammonium salt
... L-type calcium channel is the main channel responsible for extracellular calcium influx and cell contraction ...to calcium channel blockers ...certain type of ion channels ...
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Energetics of divalent selectivity in a calcium channel: the ryanodine receptor case study
... On the other hand, much of the work on the CSC mechanism has been done with equilibrium simulations that do not compute current, but only channel occupancy (8-12,14). When current was computed, it required data-fitting ...
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Energetics of divalent selectivity in a calcium channel: the ryanodine receptor case study
... RyR calcium channels have very different permeation and selectivity properties: the L-type channel has a small conductance (1) and micromolar Ca 2+ affinity (2,3) while RyR has a large conductance ...
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Comparative Experimental Studies of Calcium Channel Agonists and Antagonists against Ovariectomy Induced Osteoporosis In Rats
... dependent calcium channels (VDCC) are expressed on bone ...these channels in bone ho- meostasis is found to be ...drugs calcium channel agonist CCA (+) Bay-K-8644 has shown protective effects ...
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Binding and Selectivity in L-Type Calcium Channels: A Mean Spherical Approximation
... Substantial excluded volume effects in a molecular pore raise the question of mechanical stability. An upper limit for the force exerted on the channel wall is given by the osmotic pressure that the filter contents would ...
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How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?
... of calcium-dependent phosphorylation events is much more ...kinase type-1γ (PIPKIγ90), CaMKII and cyclin dependent kinase 5 (Cdk5) in growth cone motility (Tojima et ...caged calcium activated the ...
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