tamoxifen resistance
Acquisition of epithelial mesenchymal transition phenotype in the tamoxifen resistant breast cancer cell: a new role for G protein coupled estrogen receptor in mediating tamoxifen resistance through cancer associated fibroblast derived fibronectin and β1 integrin signaling pathway in tumor cells
... clinical tamoxifen-resistant breast tumor ...in tamoxifen resistance and tumor ...overcome tamoxifen resistance in breast cancer, and β1-integrin may be a promising ...
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Identification of potential gene associated with berberine in overcoming tamoxifen resistance by functional network analysis
... of tamoxifen-resistant MCF-7 cells were obtained from GSE67916, entitled “Gene expression profiling identifies Src family tyrosine kinase as an important molecule in tamoxifen resistance and a ...
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The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy
... in tamoxifen-resistant breast cancer cell line and tumor tis- sues, and silencing H19 sensitizes MCF7/TAMR cells to tamoxifen treatment both in vitro and in ...cause tamoxifen-resistant breast ...
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Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen resistance indicate a potential role of cells with stem like properties
... In our study, not all genes exhibiting altered gene expres- sion also exhibited corresponding promoter methylation changes, perhaps due to the resolution of the MMSDK method that did not identify all methylation ...
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PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients
... with tamoxifen resistance. In our primary analysis, we tested the clinical validity of these molecular alterations as single markers, analyzed as binary factor. Covariate adjusted Cox proportional hazard ...
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Original Article The correlation between autophagy and tamoxifen resistance in breast cancer
... Abstract: Tamoxifen is recommended as a first line treatment for estrogen receptor positive breast ...endocrine resistance remains the biggest hurdle to achieving treatment ...endocrine resistance ...
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Proteomic analysis of acquired tamoxifen resistance in MCF 7 cells reveals expression signatures associated with enhanced migration
... endocrine resistance mechanisms is largely based on the study of relatively few ...a tamoxifen resistant cell line derived from the wild type MCF-7 par- ental ...of tamoxifen resistance have ...
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<p>SRC Promotes Tamoxifen Resistance in Breast Cancer via Up-Regulating SIRT1</p>
... in tamoxifen resistance in vivo, T47DR cells with stable overexpression of SRC (T47DR/LV-OE-SRC), stable knockdown of SRC (T47DR/LV-sh-SRC) and normal control (T47DR/LV-NC) were subcutaneously injected into ...
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Mitochondrial “power” drives tamoxifen resistance : NQO1 and GCLC are new therapeutic targets in breast cancer
... the tamoxifen-resistance phenotype in human breast cancer ...using tamoxifen-resistant cell ...a tamoxifen-resistant metabolic phenotype, characterized by i) increased mitochondrial ...
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AFF3 upregulation mediates tamoxifen resistance in breast cancers
... assessed tamoxifen sensitivity by growing the AFF3 knockdown and control cell lines in the presence of estrogen and ...the tamoxifen resistance compared with the control TamR clones ...improve ...
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GPR30 as an initiator of tamoxifen resistance in hormone dependent breast cancer
... of tamoxifen resistance in MCF-7 cells during endocrine treatment, but the pre- cise molecular mechanism to explain how GPR30 causes an imbalance between inhibition and stimulation of the Erk1/2 pathway ...
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Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer
... HBXIP co-activates HOXB13 to stimulate IL-6 transcription HOXB13, as a transcription factor, is capable of inhibiting ER-α and upregulating IL-6 expression in the promotion of TAM resistance [43]. Therefore, we ...
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Phosphorylated p 70S6K predicts tamoxifen resistance in postmenopausal breast cancer patients randomized between adjuvant tamoxifen versus no systemic treatment
... examined tamoxifen bene- fit when the markers were implemented as continuous lin- ear ...with tamoxifen treatment, we ex- plored which level of dichotomization best predicted tam- oxifen benefit, by ...
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Proteomics profiling identify CAPS as a potential predictive marker of tamoxifen resistance in estrogen receptor positive breast cancer
... of tamoxifen therapy (referred to as relapse group) and patients with a relapse-free survival of more than seven years (referred to as control group) included twenty-four patients (12 patients in each ...adjuvant ...
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A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1
... resistance to endocrine therapy. Previous studies have shown that this resistance is associated with the UPR response and elevated signal transduction pathways such as the EGFR/MAPK, PI3K/AKT/mTOR pathways ...
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Long noncoding RNA H19 mediated the chemosensitivity of breast cancer cells via Wnt pathway and EMT process
... cancer. Tamoxifen was one of the most popular endocrine therapies for early-stage estrogen receptor (ER) + breast cancer ...drug resistance develops along with poor prognosis in breast ...cancer ...
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Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer
... however, tamoxifen resistance is frequently ...of tamoxifen resistance, we performed a systematic analysis of miRNA-mediated gene regulation in three clinically-relevant ...
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Original Article Sensitization to tamoxifen by tanshinone IIA in tamoxifen-resistant breast cancer cells in vitro
... of tamoxifen is mainly dependent on the expression of the estrogen receptor (ER) in the breast ...develop tamoxifen resis- ...modulating tamoxifen resistance and Tanshinone IIA (TSA) exhibits ...
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Nogo B receptor increases the resistance to tamoxifen in estrogen receptor positive breast cancer cells
... validate tamoxifen resistance in established MCF-7-TamR and T47D-TamR cells, both normal and tamoxifen-resistant cells were treated with 0–5 μM ...to tamoxifen (Additional file 1: Figure S1A ...
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Original Article S100A16 overexpression reduces sensibility of MCF-7 cells to tamoxifen via downregulation of ERα and PI3K/AKT-mediated activation of ERα
... facilitate resistance of chemothera- py and endocrinotherapy via certain mecha- nisms ...to tamoxifen resis- ...in tamoxifen resistance of human breast cancer and possibly provided a potential ...
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