Target site
Host Genes That Affect the Target-Site Distribution of the Yeast Retrotransposon Ty1
... Ty1 target-site preference within an RNAP II transcribed ...The target in this system is a functional fusion of the regulatable MET3 promoter with the URA3 ...Ty1 target-site ...
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The Chromodomain of Tf1 Integrase Promotes Binding to cDNA and Mediates Target Site Selection
... of target sequence for integration by retrovi- ruses such as HIV and murine leukemia virus (MLV) has important consequences for both the virus and the ...their target site preferences, the use of ...
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Target Site Insensitivity Detection in Deltamethrin Resistant Culex pipiens Complex in Iran
... used to control many agricultural pests and dis- ease vectors (4). Unfortunately, natural selection of resistance in vector populations has happened for every class of insecticides, which has exclu- sive effect on their ...
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Alterations in life-history associated with non-target-site herbicide resistance in Alopecurus myosuroides
... herbicide target enzyme or reduce herbicide-target binding (target site resistance, TSR), or via changes in the rates of herbicide absorption, translocation, degradation or sequestration ...
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Combined target site (kdr) mutations play a primary role in highly pyrethroid resistant phenotypes of Aedes aegypti from Saudi Arabia
... involve target site alterations and metabolic resistance, comprising altered activity of enzymes from three superfamilies, esterases (CCEs), glutathione-s-transferases (GSTs) and cytochrome P450s (CYP450s), ...
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Metabolic and Target-Site Mechanisms Combine to Confer Strong DDT Resistance in Anopheles gambiae
... insecticide target site (target-site resistance), or elevated activity of detoxifying enzymes that metabolise and/or sequester insecticides (metabolic ...the target of both DDT and ...
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Microdialysis: the key to physiologically based model prediction of human CNS target site concentrations
... the target site concentrations of CNS drugs is not straightforward because plasma concentrations do not adequately reflect CNS exposure, primarily due to the presence of the blood-brain barrier (BBB) and the ...
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Therapeutic target site variability in α1 antitrypsin characterized at high resolution
... from its metastable native state to hyperstable forms provides a motive force for its antiprotease function. However, aberrant conformational change can also occur via an intermolecular linkage that results in ...
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Ribozymes which cleave arenavirus RNAs: identification of susceptible target sites and inhibition by target site secondary structure.
... As well as demonstrating the effect of secondary structure on cis-acting ribozyme cleavage, we have shown trans activity of five ribozymes, all directed toward different target sites.. W[r] ...
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Precise repair of mPing excision sites is facilitated by target site duplication derived microhomology
... DNA TEs and their associated MITEs are mobilized by a “cut and paste” mechanism in which transposase proteins bind to the terminal inverted repeats (TIRs), effectively positioning the catalytic domain for the DNA ...
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Influences of Histone Stoichiometry on the Target Site Preference of Retrotransposons Ty1 and Ty2 in Saccharomyces cerevisiae
... is due to tran- scription factors present in the RNA polymerase I11 transcription apparatus (KIRCHNER el al. These studies indicate that host proteins are di- rectly [r] ...
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ClinSeK: a targeted variant characterization framework for clinical sequencing
... ClinSeK is designed to operate on paired-end reads of lengths ranging from 75 bp to 500 bp, which is currently the most widely used platform for clinical sequencing. Traversing raw FASTQ reads, ClinSeK records the num- ...
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Comparison of DNA binding and integration half-site selection by avian myeloblastosis virus integrase.
... Alignment of 70 target site sequences 5' of the LTR half-site insertions with 68 target sites previously identified for the concerted insertion of both LTR termini LTR full-site reaction[r] ...
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Successful Transient Expression of Cas9 and Single Guide RNA Genes in Chlamydomonas reinhardtii
... mutagenized target sites using restriction enzyme digestion of PCR-amplified sgRNA target site regions present in mu- tagenized ...sgRNA target sites in hygromycin, mGFP, Gluc, and FKB12 genes ...
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Efficient genome editing of genes involved in neural crest development using the CRISPR/Cas9 system in Xenopus embryos
... Recent reports indicated the off-target mutations induced by Cas9 in cultured cell lines [11, 35–37]. We also observed substantial off-target effects when we used Cas9 to target sox9 locus. Since the ...
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Study on Wind Speed Correlation between UNITEN and Meteorological Station Data for Wind Resource Assessment Vola Osea 1, Eqwan M.R. 1*
... the target site, showing the highest wind speed recorded to be ...the target site is higher than the speed at the reference site, showing the importance of on-site data ...
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Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis
... While it is well established that miRNAs play an impor- tant role governing gene expression, the correlation of mRNA and miRNA profiles across the entire genome and in response to an acute cellular perturbation (such as ...
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Norovirus Whole Genome Sequencing by SureSelect Target Enrichment: a Robust and Sensitive Method
... In target enrich- ment, baits are designed using all publically available norovirus sequences, across all GI and GII genotypes; unlike PCR, which uses a single primer at each target site, multiple ...
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Class II Transposons ; also known as Miniature I nverted-repeatsT ransposable Elements or MITE s. Class III Retrotransposons that first transcribe the
... These are also called non LTR transposons. They are large widely distributed transposons. They move through an RNA molecule and then reverse transcribed into DNA. They create target site duplication but do ...
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Microspheres: a Novel Drug Delivery System an Overview
... the target site in a sustained controlled release ...the target site with specificity, if modified, and to maintain the desired concentration at the site of interest without untoward ...
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