TAT protein
Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein.
... To address the role of the conserved basic domain of the tat protein in the trans-activation of HIV-1 LTR-specific gene expression, we used oligonucleotidedirected mutagenesis 35 to alte[r] ...
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The HIV-1 Tat Protein Has a Versatile Role in Activating Viral Transcription
... HIV-1 Tat protein enhances transcription from the proviral genome by binding to the TAR hairpin that is formed at the 5 ⬘ end of the nascent ...transcript. Tat recruits transcrip- tion elongation ...
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A Mutant Tat Protein Inhibits HIV-1 Reverse Transcription by Targeting the Reverse Transcription Complex
... HIV-1 Tat protein, termed Nullbasic, which can potently inhibit multiple steps of the HIV replication cycle ...wild-type Tat with glycine/alanine residues. Given that Tat has reported ability ...
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Regulation of the Human Endogenous Retrovirus K (HML-2) Transcriptome by the HIV-1 Tat Protein
... (or not) in each treat- ment. As can be seen, most HERV-K (HML-2) proviruses are already expressed at what we deemed a basal level (vehicle-treat- ment columns). Treatment with HIV-1 Tat protein caused ...
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Transactivation and signaling functions of Tat are not correlated: biological and immunological characterization of HIV 1 subtype C Tat protein
... the protein solutions (B-Tat, C-Tat and p24) contained trace levels of endotoxin, below ...of protein that corresponds to 5 pg of ...corresponding Tat protein, respectively, as ...
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Shutdown of HIV 1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein
... by Tat, was strongly inhibited by NB- ...mutant Tat protein and the roles of wild-type Tat in chromatin remodeling and transactivation are diverse and ...HIV-1 Tat can recruit the ...
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Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region
... transduction, protein subcellular localization, gene transcription, and protein-protein interactions that ultimately alter gene ...cellular protein arginine methyltransferases (PRMT) in viral ...
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Roles and functions of HIV 1 Tat protein in the CNS: an overview
... cell, Tat reveals the very complex and unconventional network of tasks that this protein caries and the potential for future ...of Tat peptides to drive different size molecules ...for Tat ...
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Visna virus Tat protein: a potent transcription factor with both activator and suppressor domains.
... To investigate the mechanism of action of the visna Tat protein and to localize the protein domains responsible for transcriptional activation, chimeric proteins containing visna virus T[r] ...
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Inhibition of human immunodeficiency virus type 1 and type 2 Tat function by transdominant Tat protein localized to both the nucleus and cytoplasm.
... HIV-1 Tat protein and its functional domains (19, 28, 41, 57, 58) are shown in ...of Tat. To evaluate the ability of the mutant Tat proteins to activate HIV gene expression and to inhibit ...
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Increased expression of CD4 molecules on Jurkat cells mediated by human immunodeficiency virus tat protein.
... Our findings suggest that the single expression of the human immunodeficiency virus tat protein in the absence of the other viral proteins causes an upregulation of CD4 gene expression o[r] ...
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Exosomal Tat protein activates latent HIV-1 in primary, resting CD4+ T lymphocytes
... Exosome Protein Engineering Technology (System Biosciences), the cDNA fragment encoding HIV-1 Tat protein with c-Myc NLS fused to its C-terminus was sub- cloned into XPack CMV-XP-MCS-EF1-Puro Cloning ...
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HIV 1 Tat protein enhances Microtubule polymerization
... that Tat directly interacts with microtubules and is able to enhance their ...that Tat strongly enhanced pure tubulin polymerization. The Tat concentration inducing tubulin polymerization is higher ...
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The maedi-visna virus Tat protein induces multiorgan lymphoid hyperplasia in transgenic mice.
... 8 0022-538X/94/$04.00+0 Copyright C 1994, American Society for Microbiology The Maedi-Visna Virus Tat Protein Induces Multiorgan Lymphoid Hyperplasia in Transgenic Mice CHRISTINE VELLUTI[r] ...
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Inhibition of HIV derived lentiviral production by TAR RNA binding domain of TAT protein
... the TAT and REV proteins were still required for producing lentiviral vectors and were provided by separate ...on TAT, we should be able to design experiments to examine anti-HIV approaches that target the ...
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Modulation of microtubule assembly by the HIV 1 Tat protein is strongly dependent on zinc binding to Tat
... HIV-1 Tat protein, which is pro- duced by HIV-infected cells and is efficiently taken up by the neighboring cells ...[3-5]. Tat is an 86 to 106-amino acid-long protein whose primary role is to ...
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Mechanism of HIV 1 Tat RNA translation and its activation by the Tat protein
... the Tat and the Rev factors are absolutely required for viral gene expression at the transcriptional and post-transcrip- tional levels in infected cells ...HIV-1 Tat is a small basic protein that ...
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Effects of a highly basic region of human immunodeficiency virus Tat protein on nucleolar localization.
... 4 0022-538X/90/041803-05$02.00/0 Copyright C 1990, American Society for Microbiology NOTES Effects of a Highly Basic Region of Human Immunodeficiency Virus Tat Protein on Nucleolar Local[r] ...
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LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein
... (Tat) protein is produced within the CNS despite adminis- tration of cART ...HIV-1 Tat protein has been found to mediate damage in the CNS by upregulating chemotactic gradients that favor ...
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The HIV-1 Tat Protein Enhances Splicing at the Major Splice Donor Site
... in Tat-activated HIV-1 transcription (24) also binds to the splicing factor SF1 ...The Tat stimulatory factor Tat-SF1 was first discovered as a cellular protein required for activation of HIV-1 ...
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