Tau and α-synuclein
Decontamination of medical devices from pathological amyloid-β-, tau- and α-synuclein aggregates
... , tau and α -synuclein may potentially add to patient ...-, tau- and α -synuclein aggregates can provide helpful ...demential α -synuclein aggregation disease (SD) ...
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Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
... decreasing α- synuclein protein. Several studies have found evidence for α-synuclein oligomers as the most toxic form of the ...oligomeric α-synuclein induces toxicity in cell ...
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Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology
... of tau and α -synuclein ( α Syn), which develop inclusion pathologies of the mutant protein in brain and spinal cord, were crossed to mice expressing low levels of mutant superoxide dismutase ...
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The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury
... as α-synuclein and tau, ER will ...of α-synuclein and excessive phos- phorylation of tau, so we want to know the relation- ship between them with ER stress, and we detected the ...
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Extensive aggregation of α-synuclein and tau in juvenile-onset neuroaxonal dystrophy: an autopsied individual with a novel mutation in the PLA2G6 gene-splicing site
... cerebral cortices, numerous cortical-type LBs, which lacked core and halo structures, and LNs were diffusely found (Figure 3b,e) with striking spongiform alterations (Figure 3b). The distribution and density of LBs and ...
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Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level
... that tau phosphorylation and trivalent metal ions such as Al 3+ act together in the formation of distinct SDS resistant tau ...of tau and α-syn can take place even at nanomolar protein ...
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What we can learn from animal models about cerebral multi-morbidity
... Aβ, tau, and ...of α-synuclein transgenic mice with prions (PrP Sc ) exacerbates the α-synuclein ...of α-synuclein [77]. Of the proteins other than tau that form ...
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Interleukin-1 mediates Alzheimer and Lewy body pathologies
... We examined the effects of microglial activation on sub- strates of neuropathological elements of AD, PD, and AD/ LBD using in vitro cell culture experiments and an in vivo pellet-implantation model. Activated microglia ...
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Extracellular α-synuclein levels are regulated by neuronal activity
... of α -synuclein, it should further be investigated whether activity-dependent release promotes transmission of α-synuclein ...that α- synuclein forms oligomers in ISF, our study ...
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LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons
... misfolded α-synuclein and mutated LRRK2 would be sufficient to drive an enhanced pathogenic ...LRRK2-dependent α-synuclein pathogenesis in primary neuron ...of α-synuclein ...
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α-synuclein in the pathophysiology of Alzheimer’s disease
... of tau which goes hand-in-hand with the strong correlations found be- tween CSF levels of αSyn and tau in multiple neurode- generative disorders including ...induce tau phosphorylation and αSyn ...
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Efficient RT QuIC seeding activity for α synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy
... folded α-synuclein in these samples was more efficient in stimulating rec-αS aggregation (homologous ...thus α-synuclein represents the unique pathological protein of otherwise usually ...
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The direct and indirect effects of α-synuclein on microtubule stability in the pathogenesis of Parkinson’s disease
... protein α-synuclein, which is the primary component of Lewy bodies, the pathologic inclusions that are the hallmark of Parkinson’s on the cellular ...of α-synuclein in causing mitochondrial ...
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Review Article Tissue Transglutaminase, Protein Cross-linking and Alzheimer’s Disease: Review and Views
... Aβ, tau, α-synuclein and neurofilament proteins, may be involved in protein aggregation in ...Aβ, tau, α-synuclein and neurofilament ...
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Protein behavior in crowded environments
... The Pielak lab published the first paper using in-cell NMR to investigate a natively-disordered protein, FlgM (19). A 15 N HSQC spectrum was collected for FlgM inside living E. coli, and crosspeaks belonging to the ...
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Original Article Silencing of SIAH1 in SH-SY5Y affects α-synuclein degradation pathway
... of α-synuclein aggregates, known as Lewy bodies, in the substantia nigra (SN) of the mid- brain ...[12]. α-synuclein exists in three forms: monomers, dimers and protofibrils ...of ...
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α-Synuclein in gut endocrine cells and its implications for Parkinson’s disease
... of α-synucle- in in STC-1 cells was analyzed by real-time PCR, immunoblotting, and ...Gapdh, α-synuclein (Snca), Cck, and Pyy in STC-1 cells compared with the SH-SY5Y neuroblastoma cell ...
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Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
... Δ71-82 α-synuclein can form oligomers as ob- served by negative staining electron microscopy, but these are not amyloidogenic in ...Δ71-82 α-synuclein used for the current studies was not ...
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Pathological alpha-synuclein propagates through neural networks
... Preparation of recombinant α syn monomer and fibrils Mouse αsyn cDNA in bacterial expression plasmid pRK172 was used. αSyn were expressed in Escherichia coli BL21 (DE3) cells and purified using boiling, ...
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α Synuclein interacts with lipoproteins in plasma
... anti- α-syn C211 , sc-58480; M illipore anti- apolipoprotein A1, AB740; Millipore anti-apolipoprotein B, AB742; Millipore anti-apolipoprotein B, AB947 and abcam anti-apolipoprotein J, ...
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