Telomerase reverse transcriptase (TERT)
Telomerase reverse transcriptase gene amplification in hematological malignancies
... of telomerase can dramatically increase proliferative life span and promote cellular immortality, thereby contributing to the malignant ...investigate telomerase reverse transcriptase (TERT) ...
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Post-transcriptional regulation of telomerase reverse transcriptase (TERT) in human embryonic stem cells cultured under varying oxygen microenvironments
... of telomerase in human embryonic stem cell potency and ...in telomerase reverse transcriptase (TERT) expression, localization, and ...in telomerase subunit expression and its ...the ...
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Telomerase reverse transcriptase methylation predicts lymph node metastasis and prognosis in patients with gastric cancer
... Purpose: Telomerase activity is associated with cellular immortalization and is present in most human tumors but absent in normal ...of telomerase reverse transcriptase (TERT), a catalytic ...
8
Association of telomerase reverse transcriptase promoter mutations with clinicopathological features and prognosis of thyroid cancer: a meta-analysis
... of telomerase reverse transcriptase (TERT) promoter mutations have been widely investigated in thyroid cancer; however, the results are still ...
12
A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis
... that telomerase expression is crucial for the maintenance of telomere homeostasis, there is increasing evidence that the TERT protein can have physiological roles that are independent of this central ...of ...
21
Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase
... Human telomerase reverse transcriptase (hTERT) is the catalytic component of telomerase with reverse transcriptase activity. Stem cells overexpressing hTERT maintained ...
14
Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding Sites
... induces telomerase activity in human ...activates telomerase. Expression of human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, was found to be ...
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Expression of Telomerase Reverse Transcriptase during the Malignant Transformation of Cadmium Induced Cells
... human telomerase reverse transcriptase (hTERT), the telomerase RNA compo- nent, and human telomerase-associated protein I ...with reverse transcriptase activity that ...
5
Original Article Screening and identification of antisense accessible sites of the human telomerase reverse transcriptase gene in prostate cancer cell lines
... Abstract: Selecting optimal antisense binding sites remains difficult during application of antisense oligonucle- otide techniques. A random oligonucleotide library/RNase H cutting method combined with software analysis ...
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The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
... man telomerase reverse transcriptase (hTERT) gene ...of telomerase catalytic activity, encodes the reverse transcriptase com- ponent of the telomerase complex, and its ...
9
Human telomerase reverse-transcriptase promoter-controlled and herpes simplex virus thymidine kinase-armed adenoviruses for renal cell carcinoma treatment
... human telomerase reverse transcriptase (hTERT)-controlled herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) in the hTERT promoter-driven HSV-TK/ GCV suicide gene system was ...
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Alternative splicing and extra-telomeric role of telomerase reverse transcriptase isoforms in human embryonic stem cells
... transcriptase TERT-RMRP complex generates double stranded RNA (dsRNA) using RMRP as a template RNA strand. The dsRNAs are subsequently processed by Dicer1 into 22- nucleotide small-interfering RNAs (siRNAs) that ...
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Investigating the Protective Effects of Telomerase Reverse Transcriptase on Neuronal Metabolism and Resistance to Amyloid-beta
... transcription factors c-Myc, Sp1 and NF-κB, thereby increasing TERT expression and telomerase activity in spinal cord motor neurons undergoing injury 99 . This confers resistance to apoptosis mediated through ...
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Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
... The transcriptional controlling of h TERT gene is complex and includes regulation at multiple levels by various posi- tive and negative factors or pathways. Recent knowledge has come from the cloning of h TERT promoter ...
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Telomerase reverse transcriptase promoter mutations in a cohort of adult gliomas: Clinicopathological correlates
... This association was found to be statistically significant for progression free p-value 0.002 and overall survival p-value 0.006 TERT promoter mutations Studies have shown that the preva[r] ...
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Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression
... in telomerase activity is derived from the strong genetic evidence that Tert-null, unlike Terc-null, mice show delayed onset of can- cers, despite the fact that both of these mice are null for telomer- ase ...
17
Increased risk of developing lung cancer in Asian patients carrying the <em>TERT</em> rs2736098 G>A polymorphism: evidence from 3,354 cases and 3,518 controls
... and telomerase production, are signifi- cantly associated with the risk of ...where telomerase reverse transcriptase (TERT ) and cleft lip and palate trans- membrane 1-like gene (CLPTM1L) are ...
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Telomeres are elongated in rats exposed to moderate altitude
... of telomerase reverse transcriptase (TERT), hypoxia-inducible factor 1 α (HIF-1 α ), malondialdehyde (MDA) and superoxide dismutase (SOD) were ...
6
Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population
... Telomerase reverse transcriptase (TERT) is a gene within the cancer susceptibility region located at Chr5p15.33, which is associated with multiple cancer types. In this study, we validated the ...
6
Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma
... Moreover, the analysis by whole-genome sequencing allowed to discover a substantial fraction of recurrent somatic mutations in non-coding regions of human gen- ome with important regulatory effects on the gene expres- ...
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