telomere lengths
Original Article Variations of rats’ telomere lengths and gene expression levels of telomerase and telomere-binding proteins in an intracranial aneurysm model
... of telomere lengths, telomerase and telomere-binding protein expression levels ...modelling, lengths of telomeres in peripheral leucocytes were measured ...Afterwards, telomere ...
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Telomere lengths in human oocytes, cleavage stage embryos and blastocysts
... average telomere lengths in sperm, which is reflected in their offspring (Kimura et al, 2008), however, a range of environmental factors, such as smoking and obesity, that may operate through increased ...
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Long term effects of radiation exposure on telomere lengths of leukocytes and its associated biomarkers among atomic-bomb survivors
... on telomere length, its change with age, and biomarkers in A-bomb survivors, and found that telomere lengths of leukocytes displayed IR dose-dependent loss, and this dose effect on telomere ...
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Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer
... absolute telomere length measurements in tumor and normal samples as determined by Southern blotting ...short telomere length of ...long telomere lengths of ...
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Development of a DNA based aging technique for use in fisheries assessments. Final report, Australian Fisheries Research and Development Corporation Project 2007/033.
... using telomere length (TL) to estimate age was examined in school prawns, Metapenaeus macleayi, spiny lobsters Sagmariasus verreauxi and Jasus edwardsii and spanner crab Ranina ...macleayi. Telomere ...
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Normal Telomere Length Maintenance in Saccharomyces cerevisiae Requires Nuclear Import of the Ever Shorter Telomeres 1 (Est1) Protein via the Importin Alpha Pathway
... position. Telomere restriction fragment (TRF) length was defined as the point of highest signal intensity within the pre- dominant smear of Y= telomeres and was converted to base pairs by com- parison with a ...
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Telomere shortening and telomere position effect in mild ring 17 syndrome
... the telomere size was analyzed with ISIS software (Meta- Systems, ...calculates telomere lengths as the ratio between the fluorescence of each telo- mere signal and the fluorescence of the centromere ...
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Short telomere length and its correlation with gene mutations in myelodysplastic syndrome
... the telomere lengths of MDS patients at a single-cell level by quantitative FISH assessing the shortest TL in each individual along with the average and distribution of ...short telomere ...
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Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis
... assay. Telomere lengths were measured on paraffin-embedded tissue sections by Q-FISH ...and telomere signal intensity quantified using MetaMorph imaging analysis software (Molecular ...
12
A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis
... of telomere elongation helicase 1 (RTEL1), or poly(A)-specific ribonuclease (PARN), have been found to occur in 8–15% of familial IPF and up to ...measured telomere length in the lungs [6, 11]. These stud- ...
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Telomere Binding of Checkpoint Sensor and DNA Repair Proteins Contributes to Maintenance of Functional Fission Yeast Telomeres
... 1.—Telomere lengths of various checkpoint-, DNA repair-, and telomere-related protein mutant ...ensure telomere length ...the telomere-associated sequence (TAS) 30–40 bp away from ...
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The diagnosis and treatment of dyskeratosis congenita: a review
... the structure of the telomeric terminus, generates T-loops, and controls the synthesis of telomeric DNA by telomerase. If the shelterin has defects in its function, there is an inad- equate damage response, and ...
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Measuring vertebrate telomeres: applications and limitations
... measure telomere lengths of single ...of telomere lengths of individual ...shortest telomere, rather than the average, is critical for loss of telomere function (Hemann et al ...
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The association of telomere length with substance use disorders: systematic review and meta-analysis protocol
... on telomere length and SUDs to determine whether persons with SUDs have shorter telomere lengths compared with healthy con- trols, (ii) to explore potential differential effects with re- gard to ...
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Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells
... induce telomere dysfunction and induce DNA damage signaling when their levels are reduced at telomeres [1–3, 29, ...the telomere, without affecting the association of TRF1 to the telomere, in ...
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PTOP and TRF1 help enhance the radio resistance in breast cancer cell
... the telomere length and radio resistance were positive ...the telomere length would lead to the decreasing of radio sensitivity, and the telomerase negative cells are significant more sensitive to ...that ...
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Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis
... long-term telomere dysfunction (from germ line to adult- ...transient telomere dysfunction during early or late stages of tumorigenesis promotes cancer formation in telom- erase-proficient mice that did not ...
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Spatial reorganization of telomeres in long lived quiescent cells
... SIR-mediated telomere clustering drives chromosome conformation in the dense fraction of SP ...arrowheads: telomere – telomere contacts in hml Δ and hml Δ sir3 Δ G0 cells, ...arm lengths, from ...
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Research Progress on Aging Mechanisms
... including telomere shortening, DNA damage, high oxida- tive stress, sustained stimulation of mitogen, and other cell stress [4] ...of telomere function, and then similar signal of DNA damage is generated, ...
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Variation in early life telomere dynamics in a long lived bird: links to environmental conditions and survival
... All statistical analyses were performed in R 3.0.0 (R Core Team, 2013). Linear mixed models (LMMs) with a normal error structure were fitted to data on nestling telomere length to examine change in TL in surviving ...
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