telomere shortening
Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells
... of telomere shortening in the growth retardation of G4 mutant NSCs in vitro are supported by the observation that proliferation deficits correlate with a rise in the detectable levels of nuclear ...of ...
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The aging lung: tissue telomere shortening in health and disease
... and telomere shortening may occur at different rates depending on the cell ...determine telomere length on a large ...between telomere length and lung ...
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Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model
... factor. Telomere shortening as a result of the inability to fully replicate the ends of linear chromosomes is one of the hallmarks of ...of telomere dysfunction in neurological diseases and the ...
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Telomere Shortening in Blood Leukocytes of Patients with Chronic Obstructive Pulmonary Disease
... to telomere shortening with each cellular division in cell cycle ...Since telomere length determines the number of cell divisions and proliferation rate of somatic cells, it has been considered as a ...
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Does Telomere Shortening Precede the Onset of Hypertension in Spontaneously Hypertensive Mice?
... The BPH/2J mice are a model of neurogenic hyperten- sion and have been shown to exhibit exaggerated activ- ity of the sympathetic nervous system in response to ad- verse stress (Davern et al., 2010). Clinical studies ...
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A Protein Array Screen for Kaposi's Sarcoma-Associated Herpesvirus LANA Interactors Links LANA to TIP60, PP2A Activity, and Telomere Shortening
... LANA expression is associated with telomere shortening. In budding yeast, cells carrying an N-terminal deletion in the yeast homolog of RPA2, Rfa2p, have impaired loading of the Est1p pro- tein onto ...
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Medaka fish exhibits longevity gender gap, a natural drop in estrogen and telomere shortening during aging: a unique model for studying sex-dependent longevity
... progressive telomere shortening in most organs as it ages ...in telomere has never been reported in ...both telomere length and longevity exist in fish?” Sup- ported by the positive outcomes, ...
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Consequences of Telomere Shortening at an Active VSG Expression Site in Telomerase-Deficient Trypanosoma brucei
... and shortening at the active VSG 221 expression site. Telomere length changes at the active VSG 221 ES can be visualized by digestion with EcoRI and hybrid- ization with a VSG 221 probe ...ES ...
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Telomere shortening and accelerated aging in COPD: findings from the BODE cohort
... limitations. Telomere length was measured on circulating leukocytes and therefore our findings may not reflect the process occurring in the whole ...Interestingly, telomere length in blood cor- relates well ...
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Demonstration of potential link between Helicobacter pylori related promoter CpG island methylation and telomere shortening in human gastric mucosa
... with telomere shortening than genome wide hypo ...Since telomere shortening and increased PCGI hypermethylation in ...to telomere shortening and increased PCGI hypermethylation, ...
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Telomere shortening and telomere position effect in mild ring 17 syndrome
... The telomere shortening observed in the patient with respect to the mother ap- pears as an additional factor that might have influenced the generation of the ring chromosome and the occur- rence of this ...
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Sepsis induces Telomere Shortening: a Potential Mechanism Responsible for Delayed Pathophysiological Events in Sepsis Survivors?
... that telomere shortening (which is typically considered a progres- sive and irreversible process) contributes to a phenomenon of “accelerated aging” in post-sepsis ...the telomere shortening ...
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Telomere shortening in leukocyte subpopulations in depression
... depression-related telomere shortening was assumed to have an increasing effect with ...on telomere shortening all participants were females recruited by newspaper announcement and public ...
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Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers
... accelerate telomere shortening [2,6,7]. In human studies, telomere length measured in leukocyte DNA decreases with age [8,9], and telomere attrition in blood leukocytes has been shown to be ...
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Telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitis
... Short telomeres predispose to end-to-end fusions of chromatids, ultimately leading to chromosome breaks and chromosome losses [18,37]. We did not find any as- sociations between the amount of ultra-short telomeres and ...
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Can telomere shortening be the main indicator of non-viable fetus elimination?
... death. Telomere dysfunction has also been linked to chromosomal rearrangements and genomic ...of telomere length in prenatal development is still poorly understood, and mainly concerns the preimplantation ...
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Association of chronic fatigue syndrome with premature telomere attrition
... thus telomere length represents the replicative his- tory of cells and dictates cells’ life span ...leukocyte telomere length was found to be longer in adult women than men [13, ...ally, telomere ...
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Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls
... shortened telomere length [22, 23] illustrating the significant role of ...associated telomere length [14, 24, ...of telomere shortening over 5 years in coronary heart disease patients in a ...
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How Yeast Can Inform Us about Healthy Aging
... Yeasts are eukaryotes like us, and they have informed us about our cellular and molecular biology for many decades. They are unicellular and live with 6000 genes, carrying out many of the same processes that we do. Like ...
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Isolation and characterization of genes involved in DNA damage response and telomere maintenance in Caenorhabditis elegans
... in telomere shortening and an Mrt phenotype (Chapter 4) (Hofmann, Milstein et ...complete telomere replication ...or telomere fusions as a result of telomere shortening ...
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