Telomeric DNA
Telomeric DNA in normal and leukemic blood cells
... the telomeric repeats in the various populations of normal blood cells obtained from donors in their twenties to sixties, and the telomere length ranged between ...of telomeric DNA, ranging from ...
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Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
... for telomeric DNA in order to measure the numbers of uncapped telomeres and other types of DNA double-strand breaks (DSBs) (Figure 1A and 1B) ...
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Dynamics of Telomeric DNA Turnover in Yeast
... adds telomeric DNA repeats to telomeric termini using a sequence within its RNA subunit as a ...synthesized telomeric repeats, was indistinguishable from wild type in all phenotypes assayed: ...
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Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells
... In MCF-7 breast cancer cells, T-oligos activate and induce DNA damage response proteins that cause apoptosis and senescence of cells. Senescence was determined by β -gal activity and failure to incorporate BrdU or ...
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“Telomeric DNA: New Target For Anticancer Drug Development” by Smita Jain, Neelam Satija, India.
... The two components of the telomerase, the TERT and the TR, align together to form a complex and work in sync together for the elongation of the telomere component. The third component dyskerin is also present, possibly ...
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Extra telomeres, but not internal tracts of telomeric DNA, reduce transcriptional repression at Saccharomyces telomeres.
... The fraction of 5-FOA' cells in individual colonies grown on YGtrp medium containing galactose was de- termined for both strain A and strain A-GS3 carrying the circu[r] ...
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De novo assembly of potential linear artificial chromosome constructs capped with expansive telomeric repeats
... uses telomeric DNA to truncate a native chromosome thereby generating minichromosomes ...and telomeric DNA followed by transform- ing the target plant with the constructs ...
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Consequences of Telomere Shortening at an Active VSG Expression Site in Telomerase-Deficient Trypanosoma brucei
... deficient T. brucei. (A) (Upper panel) EcoRI telomere terminal re- striction fragment hybridized with VSG 221. Progressive telomere shortening and breakage lead to loss of telomeric DNA at the active ES and ...
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Tetrahymena Pot2 Is a Developmentally Regulated Paralog of Pot1 That Localizes to Chromosome Breakage Sites but Not to Telomeres
... either telomeric DNA or the CBS consensus sequence sug- gests several novel functions for this member of the POT protein ...the DNA cleavage ...
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Development of a series of bis triazoles as G quadruplex ligands
... of telomeric DNA, for which appropriate small molecule ligands can induce G-quadruplex formation, stabilize its structure, inhibit telomerase activity and telomere elongation, and selectively target ...
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Emerging roles of telomeric chromatin alterations in cancer
... double-stranded telomeric DNA prevalently in circular form (t-circles), partially single-stranded telomeric C-rich circles (C-circles), high telomere-specific DDR, telomere sister chromatid exchanges ...
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The shelterin complex and hematopoiesis
... chromosomes. Telomeric DNA con- sists of repetitive sequences with a short single-stranded, G-rich overhang preceded by a much longer double-stranded ...of telomeric DNA varies between species ...
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Electronic transport in DNA
... of DNA is another possibility, which can be modeled by a local, perhaps regular, change in e q i along the ...which DNA is normally ...four DNA sequences as a function of energy for W ¼ ...and ...
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Alternative splicing and extra-telomeric role of telomerase reverse transcriptase isoforms in human embryonic stem cells
... The telomerase RNP complex plays a crucial role in maintaining telomere homeostasis. To enable rapid and indefinite cellular proliferation, cancer cell utilizes telomere-lengthening cellular machinery such as alternative ...
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Unusually stable abnormal karyotype in a highly aggressive melanoma negative for telomerase activity
... Malignant melanomas are characterized by increased karyotypic complexity, extended aneuploidy and heteroploidy. We report a melanoma metastasis to the peritoneal cavity with an exceptionally stable, abnormal ...
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The ancestral chromosomes of Dromiciops gliroides (Microbiotheridae), and its bearings on the karyotypic evolution of American marsupials
... Sparse heterochromatin distribution and few dispersed repetitive sequences on interstitial and centromeric re- gions characterize the karyotype of D. gliroides (Figs. 1b and 2a). This features are coherent with ...
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Coevolution of the Telomeric Retrotransposons Across Drosophila Species
... Figure 2.—Diagrams of the three D. yakuba phage clones stud- ied. (A) Telomeric clones. (B) Y chromosome clone. Each retro- transposon is identified above the element; sequence regions are in- dicated below each ...
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Intracellular Targeting of Gag Proteins of the Drosophila Telomeric Retrotransposons
... than Pol proteins. To explore the possibility that HeT-A and TART Gags are involved in directing their RNA transposition intermediates to telomeres, we have analyzed the intracellular localization of these proteins. The ...
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Regulation of TERRA on telomeric and mitochondrial functions in IPF pathogenesis
... After extraction of the whole genome DNA by Quick- Gene 610 L automatic extractor, the first qRT-PCR test was performed. The detection of telomere length primer was as follows: SEQ ID NO.1: CGGTTTGTTTG ...
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The Promoter of the Heterochromatic Drosophila Telomeric Retrotransposon, HeT-A, Is Active When Moved Into Euchromatic Locations
... heterochromatin in the Drosophila minichromosome Dp2287 by Wallrath, L. L., 2000 Drosophila telomeric transgenes provide single P element insertional mutagenesis. Genetics 132: 737–753. insights on mechanisms of ...
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