terminal domains
Deficiency of dystrophin associated proteins in Duchenne muscular dystrophy patients lacking COOH terminal domains of dystrophin
... COOH-terminal domains (cysteine-rich and carboxyl- terminal) of dystrophin have been suggested to interact with the sarcolemmal glycoprotein ...these domains was reported to ...
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The Functional Characterization of the N-terminal Domains of TUT4
... the domains occurred early during evolution. The N-terminal domains may be less conserved because its catalytic function is less relevant for its biological ...Ntr domains of TUT4 and TUT7, ...
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Both Carboxy- and Amino-Terminal Domains of the Vaccinia Virus Interferon Resistance Gene, E3L, Are Required for Pathogenesis in a Mouse Model
... distinct domains: a conserved carboxy-terminal dsRBD and a conserved amino- terminal ...carboxy-terminal domains are re- quired for rescue of eIF-2␣ phosphorylation and the slow- growth ...
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Functional characterization of the N-terminal and C-terminal domains of a sesame group II phytocystatin
... Background: Phytocystatins are natural inhibitors of cysteine protease, and may regulate endo- or exo-genous proteolytic activities in plants. They are classified into Group I and II differing by the presence of ...
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Structural and functional consequences of switching carboxy terminal domains in mouse CD200 receptors
... Commercially available antibodies for mR1 have been used by investigators to study the surface expression of mR1 and also to study the interaction of mR1 with its ligand CD200. Since mR1 and mR2 share over 84% ami- no ...
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A structural constraint for functional interaction between N terminal and C terminal domains in simian immunodeficiency virus capsid proteins
... cytotoxic T lymphocytes (CTLs) were previously shown to respond to SIVmac239 but not SIVsmE543-3 infection. A mutant SIVmac239, SIVmac239Gag205E, whose Gag205D is replaced with Gag205E showed lower replicative ability. ...
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Crystal Structure of the Oligomerization Domain of the Phosphoprotein of Vesicular Stomatitis Virus
... functional domains at the opposite ends and brings multiple copies of P (such as a tetramer) in close proximity through ...C-terminal domains for their func- tional ...
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Functional Replacement of the Carboxy-Terminal Two-Thirds of the Influenza A Virus NS1 Protein with Short Heterologous Dimerization Domains
... dimerization domains to functionally substitute in vivo for the carboxy-terminal domains of the NS1 ...dimerization domains of either the Saccharomyces cerevisiae PUT3 or the Drosophila ...
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Long-Term Evolution and Functional Diversification in the Members of the Nucleophosmin/Nucleoplasmin Family of Nuclear Chaperones
... The presence of selection in the three main NPM lineages (1–3) was further studied by testing for deviations from neu- trality. The GC content at fourfold degenerate sites was as- sumed to represent the genomic GC ...
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Dissection of Amino-Terminal Functional Domains of Murine Coronavirus Nonstructural Protein 3
... structural domains, including two papain-like proteases (PLPs) and a highly conserved ADP-ribose-1 ⴖ -phosphatase (ADRP) ...nsp3 domains for viral RNA ...amino-terminal domains of ...
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Transcription Factor YY1 Interacts with Retroviral Integrases and Facilitates Integration of Moloney Murine Leukemia Virus cDNA into the Host Chromosomes
... C- terminal domains of MoMLV IN interact with YY1, we also performed a detailed study on its YY1-binding regions by overexpressing YY1 and Flag-tagged MoMLV IN fragments ...three domains, including ...
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Differential Contributions of Tacaribe Arenavirus Nucleoprotein N-Terminal and C-Terminal Residues to Nucleocapsid Functional Activity
... C-terminal domains has been described for the nucleoprotein of other negative-strand RNA viruses, such as rabies virus, vesic- ular stomatitis virus (VSV), respiratory syncytial virus (RSV), and several ...
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Functional analysis of the global repressor Tup1 for maltose metabolism in Saccharomyces cerevisiae: different roles of the functional domains
... functional domains of Tup1 have been identified, each of which has differing effects on transcriptional ...its domains in maltose metabolism of industrial baker’s ...
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The RNase III Family: A Conserved Structure and Expanding Functions in Eukaryotic dsRNA Metabolism
... nuclease domains and in the composition of the N-terminal domain (Filippov et ...three domains; the dsRBD, the nuclease domain, and an additional uniquely eukaryotic N-terminal domain required ...
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Structure of C-terminal Domain of Parkin, IBR-RING2
... Individual IBR and RING2 domains within the IBR-RING2 structure are shown in Figures 3.10 and 3.11. As shown previously in the human parkin IBR structure (Beasley et al., 2007), the IBR did not display any notable ...
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Application of the HTA Core Model for complex evaluation of the effectiveness and quality of Radium-223 treatment in patients with metastatic castration resistant prostate cancer
... Health problems and current use of technology (CUR) Prostate cancer is the second most frequently re- ported malignant tumor in men in Slovakia. It is also the second most frequent oncological cause of death in men in ...
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Compensatory branching morphogenesis of stalk cells in the Drosophila trachea
... branch terminal cells are indicated ...(TC, terminal cell; FC, fusion cell; SC, stalk cell) and dorsal trunk (DT) tubes are ...The terminal cell-stalk cell interface of mosaic third instar larvae, ...
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Degradation of Saccharomyces cerevisiae Transcription Factor Gcn4 Requires a C-Terminal Nuclear Localization Signal in the Cyclin Pcl5
... This is clearly not the case here, where Pcl5 and Pho80 are both nuclear cyclins. Exclusion of Pcl5 from the nucleus inhib- its Pho85 activity to initiate Gcn4 degradation. Mislocalization of Pcl5 to the cytoplasm by the ...
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The C-Terminal Repeat Domains of nsP3 from the Old World Alphaviruses Bind Directly to G3BP
... In this work, we have shown that the C-terminal L/ITFGDFD repeat regions of both SFV and CHIKV nsP3 are necessary and sufficient for G3BP binding. Supporting our findings, recently published work with chimeric ...
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Distinct Domains in ORF52 Tegument Protein Mediate Essential Functions in Murine Gammaherpesvirus 68 Virion Tegumentation and Secondary Envelopment
... Plasmid construction. To facilitate the manipulation of MHV-68 genes in the context of the viral genome, the whole genome of MHV-68 was cloned into a bacterial artificial chromosome (BAC). The construc- tion of MHV-68 ...
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