TGF-b1
Microarray identifies ADAM family members as key responders to TGF beta1 in alveolar epithelial cells
... ng/ml TGF- B1 for 15 mins, 30 mins, 2 hour and 4 hours, RNA isola- tion, cDNA synthesis, in vitro transcription and microarray analysis were performed as previously reported [31] and in accordance with ...
16
Increased expression of collagens, transforming growth factor β1, and β3 in gluteal muscle contracture
... of TGF-b are known to exist in mammals, namely TGF-b1, -b2, and -b3, each with distinct roles in wound ...repair. TGF-b1 and -b2 are potent profibrotic factors thought to be involved in ...
8
Vascular hypertrophy in experimental diabetes Role of advanced glycation end products
... vessel TGF-b1 mRNA was increased two- to threefold in diabetic animals at all time points compared to their nondiabetic counterparts ...of TGF-b1 at all time ...of TGF-b1 and a1 ...
13
Adenovector mediated gene transfer of active transforming growth factor beta1 induces prolonged severe fibrosis in rat lung
... active TGF-b1 were ...of TGF-b1 in adjacent cells in a paracrine ...of TGF-b1 on fibroblasts (1), and the rapidity and sever- ity of the fibrotic reaction also indicate that ...
10
Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells
... + TGF- b 1 or IHH only groups (Figures 5 to ...and TGF-b1 can have agonistic and antagonistic effects on proliferation and chondrogenesis and IHH reg- ulation ...
13
Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy like syndrome in PEPCK TGF beta1 transgenic mice
... aberrant TGF- b1 ex- pression and lipodystrophy, there are similarities between the transgenic mice and some of the clinical sequelae associated with ...
18
Induction of circulating myelin basic protein and proteolipid protein specific transforming growth factor beta1 secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients
... of TGF-b1–secreting cells and response to therapy by arbitrarily dividing patients into responders and nonresponders and performing a chi-square statistical ...
9
Autoimmunity associated with TGF beta1 deficiency in mice is dependent on MHC class II antigen expression
... etic precursor cells and their contribution to normal my- elopoiesis remains controversial. Expression of class II anti- gens can be found on committed hematopoietic progenitors, particularly those of the ...
12
Particle mediated gene transfer with transforming growth factor beta1 cDNAs enhances wound repair in rat skin
... cation of the technology of particle-mediated gene delivery. It also has practical value at the experimental level, since ad- vancement of our understanding of the role of cytokines in tis- sue repair is limited by the ...
10
Identification of cellular target genes of the Epstein-Barr virus transactivator Zta: activation of transforming growth factor beta igh3 (TGF-beta igh3) and TGF-beta 1.
... the TGF- b 1 promoter in B cells. It has been shown previously that TGF-b1 expression is activated during the lytic cycle in B cells and that progression of the lytic cascade is dependent on ...
7
Genomic instability in the type II TGF beta1 receptor gene in atherosclerotic and restenotic vascular cells
... of TGF-b receptor mutations for several ...to TGF-b1 resistance ...the TGF-b1 signaling system that, if mutated, would confer partial or complete resistance to TGF-b1’s ...
8
Inhibition of TGF beta 3 (but not TGF beta 1 or TGF beta 2) activity prevents normal mouse embryonic palate fusion
... Int J DeL lliol 19 345 355 (1995) 345 Origil1al Article Inhibition of TGF B3 (but not TGF B1 or TGF B2) activity prevents normal mouse embryonic palate fusion CLARE L, BRUNET, PAUL M SHARPE and MARK W[.] ...
11
Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β 1 (TGF-β 1) Axis in Hepatitis C Virus-Expressing Hepatocytes
... HCV-induced TGF-b1 production has been well ...regulate TGF-b1 expression by modulating Ca 2+ signaling and generation of reactive oxygen species (ROS), which acts through p38 MAP kinase, ERK ...
14
Transforming growth factor beta1 induces differentiation in human papillomavirus-positive keratinocytes.
... differentiation, TGF- b 1- treated and untreated AWCA rafts were harvested for paraffin embedding as described in Materials and ...with TGF- b 1 and TPA is presented in Table ...However, TGF- b 1 ...
12
Comparative expression pattern of Matrix Metalloproteinases in human glioblastoma cell lines and primary cultures
... Figure 4 Regulation of MMP mRNA expression by TNF- a and TGF- b 1. a) U251 and U373 cells were successively adjusted to grow in medium without FCS and stimulated with 10 ng/ml TNF-a and TGF-b1 for 48 ...
10
Chemotherapy Cytotoxicity of Human MCF-7 and MDA-MB 231 Breast Cancer Cells Is Altered by Osteoblast-Derived Growth Factors
... (IGF-I), and transforming growth factor beta 1 (TGF-,B1) to alter the effects of adriamycin on cell cyde and apoptosis of estrogen receptor negative (ER-) MDA-MB-231 and pos- itive (ER+)[r] ...
12
Regulation of transforming growth factor beta 1 expression by the hepatitis B virus (HBV) X transactivator Role in HBV pathogenesis
... The TGF-b1 promoter contains two Egr-1 binding sites at positions 2119 to 2111 (59-CGCCCCCGC-39) and 282 to 274 (59-CCGGGGGCG-39) (Figs. 4 and 5). To determine if these sites are specifically involved in ...
9
TGFβ family signaling: novel insights in development and disease
... the TGF family proteins in development and disease are the subject of an overwhelming array of studies in numerous labs that continue to yield interesting insights into the diverse roles of these secreted factors ...
7
EFFECT OF LACTOSE, L HPC GRADES ON FLOW PROPERTIES OF MICRONIZED TADALAFIL FORMULATED AS SOLID DOSAGE FORM
... morphology and are designed to improve the binding properties 11 . L-HPC LM from Nippon soda grade is fine particle size grade for L-HPC. It is finer than other grades used here. L-HPC NBD 21, HPC-LM and L- HPC 21 grades ...
6
Pe-accession Economic Programme Macedonia 2010
... A B B1 B2 A B B1 B2 A B B1 B2 A B B1 B2 A B B1 B2 A B B1 B2 А B B1 B2 A B B1 B2 A B B1 B2 Implementation profile Net direct budgetary impact Direct effect on budgetary revenues Direct ef[r] ...
138