TGF-beta
Controlled release of TGF-beta 1 from RADA self-assembling peptide hydrogel scaffolds
... Our studies focused on controlled release of TGF-beta 1 from RADA16 functional self-assembling peptide hydrogels as well as the promotion to cell proliferation. With 3D cell culture to the microenvironment ...
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Chamaejasmenin B, a novel candidate, inhibits breast tumor metastasis by rebalancing TGF-beta paradox
... treatment. TGF-beta is the key regulator for metastasis and influences paradoxically on cancer ...known TGF-beta blockers exert little selectivity on its functions, indiscriminately causing ...
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TGF-beta Ligands from the Hookworm Parasite, Ancylostoma caninum, in Larval Latency and Reactivation
... the TGF-beta superfamily shows 52% identity in the conserved C-terminus to both human BMP-2 and BMP-4 and is expressed in neurons based on GFP-fusion analyses (Suzuki, et ...
185
Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling
... inhibited TGF-beta-induced expression of collagen-1 and smooth muscle alpha-actin (SMA) as well as force generation by ...to TGF-beta, but significantly inhibited sustained Smad2 ...
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The TGF-beta-Pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzae
... influence TGF signalling impor- ...increased TGF- beta levels in animal models [26] which may be due to downregulation of BAMBI induced by LPS from tobacco smoke ...
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Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor beta 1 gene (TGF beta 1)
... factor beta (TGF beta) is a multifunctional protein which has been suggested to play a central role in the pathogenesis of chronic inflammation and ...of TGF beta in the pathogenesis of ...
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Perichondrial mediated TGF beta regulation of cartilage growth in avian long bone development
... to TGF- β treatment occur in a dose-dependent manner including, for example, (1) the proliferation and collagen synthesis of rabbit PC cells (Dounchis et ...exogenous TGF- β 1 by their production of active ...
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Zoledronate inhibits fibroblasts’ proliferation and activation via targeting TGF-β signaling pathway
... In the present study, we provide evidence that zoledronate can inhibit the proliferation, migration and activation of fibro- blasts via the intervention of the TGF- β signaling pathway. We found that zoledronate ...
11
Inhibition of TGF beta 3 (but not TGF beta 1 or TGF beta 2) activity prevents normal mouse embryonic palate fusion
... Int J DeL lliol 19 345 355 (1995) 345 Origil1al Article Inhibition of TGF B3 (but not TGF B1 or TGF B2) activity prevents normal mouse embryonic palate fusion CLARE L, BRUNET, PAUL M SHARPE and MARK W[.] ...
11
TGF beta 1 and 25 hydroxycholesterol stimulate osteoblast like vascular cells to calcify
... oxysterol 25-hydroxycholesterol as well as by transforming growth factor-beta 1, both known to be present in atherosclerotic lesions. The stimulation of calcifying vascular cells in the artery wall by these two ...
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TGF beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
... interleukin-1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α) are able to induce the characteristic motility, proliferation and ECM synthesis observed in mesenchymal cells with a myofi- broblast-like ...
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Role of TGF beta and myofibroblasts in supporting the propagation of human embryonic stem cells in vitro
... of TGF β in cancer biology has been extensively studied where it shifts its role from an inhibitor to a promoter of proliferation during tumor progression (Ao et ...2005). TGF β is understood to play a role ...
9
Involvement of gelsolin in TGF-beta 1 induced epithelial to mesenchymal transition in breast cancer cells
... that TGF-β1 induction increased the CD44+/CD24- subpopulation of MDA-MB231 cells ...the TGF-β1 enriched CD44+/CD24- cells the mRNA expression levels for the markers of stem cell pluripotency ...the ...
11
The TGF beta type III receptor is localized to the medial edge epithelium during palatal fusion
... endogenous TGF- β 3. One conceivable mechanism is that restricted expression of TGF- β receptors (T β Rs) in a subpopulation of cells may localize TGF- β responsiveness (Brown et ...However, ...
6
<p>G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer</p>
... In an in vitro assay, siRNA technology was used to effectively knock down the expression of G3BP1 in GC cell lines. Our fi ndings con fi rmed the outcomes of the study by Min et al, 5 which reported that C3BP1 is a potent ...
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<p>HOXD9 Activates the TGF-β/Smad Signaling Pathway to Promote Gastric Cancer</p>
... Cells were lysed using the RIPA buffer (Beyotime, Shanghai, China) and protein was extracted. Protein con- centration was determined using the BCA protein detec- tion kit (Beyotime). Tissue specimens were fi rst suf fi ...
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JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion
... after TGF  (5 ng / ml) ...h TGF  (5 ng / ml) treatment was attenuated more than 50% with siJUNB treatment are colored ...of TGF  (5 ng / ml) as ...
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TINAGL1 promotes hepatocellular carcinogenesis through the activation of TGF-β signaling-medicated VEGF expression
... Results: TINAGL1 was upregulated in human HCC tissues and associated with poor prognosis. TINAGL1 knockdown suppressed HCC cell growth, proliferation, and migration and induced apoptosis in HCC cells, whereas TINAGL1 ...
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TGF beta 1 induced epithelial to mesenchymal transition and therapeutic intervention in diabetic nephropathy
... expression of BMP-7, as a potential consequence of increased gremlin levels [59]. Gremlin limits BMP-7 availability and is markedly elevated in humans with DN [60]. This reciprocal relationship accounts for low BMP-7 ...
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KDEL tagging: a method for generating dominant negative inhibitors of the secretion of TGF beta superfamily proteins
... the TGF- b superfamily and have been well studied as central players in neural formation and dorsoventral patterning during early embryogenesis (De Robertis et ...
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