TGF-β receptor
Type III TGF β receptor downregulation generates an immunotolerant tumor microenvironment
... III TGF-β receptor (TGFBR3) and its shed extracellular domain (sTGFBR3) regulate TGF-β signaling and maintain epithelial homeostasis, with loss of TGFBR3 expression promoting ...
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The type III TGF β receptor suppresses breast cancer progression
... to TGF-β during mammary carcinogenesis? Although TβRIII was the first TGF-β receptor cloned, as it has a short cytoplasmic domain with no intrinsic kinase activity, its role in ...
13
Type III TGF β receptor promotes FGF2 mediated neuronal differentiation in neuroblastoma
... Growth factors and their receptors coordinate neuronal differentiation during development, yet their roles in the pediatric tumor neuroblastoma remain unclear. Comparison of mRNA from benign neuroblastic tumors and ...
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Regulation of TGF-β receptor activity
... including TGF- b , activin, Nodal, bone morphogenetic proteins (BMPs) and others, play vital roles in development, tissue homeostasis and some diseases development ...[1-3]. TGF- b signaling is initiated by ...
10
Inflammatory conditions partly impair the mechanically mediated activation of Smad2/3 signaling in articular cartilage
... Joint trauma is a well-established risk for the develop- ment of OA and this is often attributed to the fact that after joint injury the cartilage is overloaded in the pres- ence of inflammatory mediators. However, in ...
11
Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by Transforming Growth Factor β and Angiotensin II.
... of TGF-β receptor in the cae- cum, which are increased after LS diet (p < ...these TGF- β receptors may be associated with capillaries as there is much more extensive blood supply in ...
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Modulation of cerebral endothelial cell function by TGF-β in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition
... of TGF-β in the context of glioblastoma in vitro, using human brain-derived microvascular endothelial cells (hCMEC/D3) and glioblastoma-derived endothelial cells (GMEC) as model ...that TGF-β ...
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Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini
... A TGF-β receptor type I from Opisthorchis ...(TGF-β receptor type I – L11695) ...human TGF-β receptor type I sequences shown here are truncated at the ...
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Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5
... the TGF-β receptor(s) has remained ...factor receptor signalling pathways can contribute to renal fibrosis ...for TGF-β /ALK5 signalling and, if so, whether this impacts ...
15
Final
... II TGF-β receptor mRNA at 96h ...of TGF-β3 and its receptor TβRII, leading us to speculate that TGF-β may play a role in mediating the luteinizing actions of LH (or ...of ...
132
TGFβ signaling supports survival and metastasis of endometrial cancer cells
... (TGF β ) type II receptor (RII) with microsatellite instability revealed a signifi cant molecular mechanism of tumorigenesis and tumor progression in gastrointestinal carcinomas with DNA replication ...
10
Inhibiting Cxcr2 disrupts tumor stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
... epithelium–specific TGF-β receptor type II (Tgfbr2) knockout mice in the context of Kras activation (mice referred to herein as Kras+Tgfbr2 KO mice) and found that they developed aggressive PDAC that ...
13
Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling
... of TGF-β receptor 1 (TβR1) through decreased degradation of ubiquitin, increased levels of phosphorylated SMAD3 and TGF-β-induced epithelial-mesenchymal transition ...the ...
14
TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
... whether TGF-β1 or TGF-β2 secretion impacts on TGF-β signaling in ...that TGF-β1 can influence the expression of its signaling receptors [39], we analyzed TGF-β ...
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The use of cystatin C to inhibit epithelial–mesenchymal transition and morphological transformation stimulated by transforming growth factor β
... [2,19]. TGF-β stimulation of EMT is studied routinely in murine NMuMG MECs, which readily undergo EMT when treated with TGF-β ...to TGF-β, NMuMG cells undergo transition into ...
10
Modulation of noncanonical TGF β signaling prevents cleft palate in Tgfbr2 mutant mice
... either TGF-β receptor type I (TGFBR1) or TGF-β receptor type II (TGFBR2), such as those with Loeys-Dietz syndrome, have craniofacial defects and signs of elevated ...
14
Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models
... mediates TGF-β/Smad signaling, which has been shown to be critical for the bone metastasis signature of MDA- MB-231 cells ...with TGF-β signaling inhibits integrin expression and ...
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Grigorescu Vlass, Melissa (2018): Inflammasome-independent NLRP3 signaling in chronic kidney disease. Dissertation, LMU München: Medizinische Fakultät
... upon TGF- β1 stimulation was decreased in cells lacking NLRP3, supporting previous studies performed in other fibroblasts including gingival and cardiac fibroblasts, where the latter also enhanced NLRP3 expression ...
127
Angiotensin receptor blockade attenuates cigarette smoke–induced lung injury and rescues lung architecture in mice
... dysregulated TGF-β signaling associates with lung pathology in patients with COPD and in animal models of lung injury induced by chronic exposure to cigarette smoke (CS), we postulated that inhibiting ...
13
Valsartan blocks thrombospondin/transforming growth factor/Smads to inhibit aortic remodeling in diabetic rats
... mRNA in diabetic aortas, that of the factors A-TGFβ, TβRII, and p-Smad2/3 was upregulated, as was cellular staining, which indicates TGFβ1 signaling activity. TSP1 is an extracellular calcium-binding multifunctional ...
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