TGF-β/Smad
Original Article PDK4 regulates human cardiomyocyte viability, apoptosis, and inflammatory response via inhibiting TGF-β/Smad signaling pathway
... of TGF-β1, Smad2, and Smad3 [15]. Smad protein-dependent pathway is one of the classical signaling pathways of TGF-β1, and its role in glycosaminoglycan elon- gation of cardiac non-myocyte is mainly ...
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Matrine Suppresses Pancreatic Fibrosis by Regulating TGF β/Smad Signaling in Rats
... the TGF-β/ Smad pathway in pancreatic ...of TGF-β1, α-smooth muscle actin (α-SMA), and collagen I in pancreatic tissues was assessed by immunohistochemical ...of TGF-β receptor 1 ...
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TGF-β/SMAD signaling regulation of mesenchymal stem cells in adipocyte commitment
... the TGF-β signal- ing in some cases, and sometimes BMP2 had a role in adipocyte commitment independent of TGF-β/SMAD sig- ...under TGF-β/SMAD ...and ...
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Effect of curcumin on an animal model with hepatic fibrosis via tgf β/smad signaling pathway
... the TGF-β/Smad signaling ...them, TGF-β is one of the most effective profibrotic factors, and it plays a key role in promoting the development of liver fibrosis Caja, ...2018. ...
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Original Article Inhibition of TGF-β-Smad signaling attenuates hyperoxia-induced brain damage in newborn rats
... of TGF-β in brain tissue under hyperoxia, neonatal rats were sub- jected to hyperoxic conditioning (80% O 2 ...for TGF-β analysis. As shown in Figure 1A, intra- cephalic TGF-β ...
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Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin
... of TGF-β/Smad signaling and renal fibrosis was performed in 4μm paraffin-embedded tissue sections of mouse kidney tissue using a microwave-based antigen retrieval technique ...to TGF-β1, ...
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Original Article Cross-talk between TGF-β/Smad pathway and Wnt/β-catenin pathway in pathological scar formation
... Abstract: TGF-β1 is a key factor in the process of wound healing, which is regulated by TGF-β/Smad ...that TGF-β1 contributed to pathological scar ...evaluating TGF-β1 and ...
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Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling
... and TGF-β-induced ...of TGF-β are ...by TGF-β to activate ...various TGF-β/ Smad pathway antagonists are being partial successfully used in clinical trials ...
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Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD independent TGF β signalling pathway
... abolishes TGF-β induction of MMP13 in human breast cancer cell lines [33], and the inhibition of the MAPK pathways reduces TGFB1-stimulated MMP13 expression in the rat osteosar- coma cell line (UMR 106-01) ...
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Schisandrin B attenuates CCl<span style="font-size: 8.33333px">4</span>-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways
... (TGF- β )/Smad signaling ...inhibited TGF- β-induced HSC ...inhibited TGF-β1-stimulated phosphory- lation of Smad and signaling of mitogen-activated protein ...and ...
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Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats
... of TGF- β /Smad/CTGF signaling pathway, increased oxidative stress level, and impaired renal function, and ICA II was able to functionally and structur- ally restore these ...
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<p>Circ-OXCT1 Suppresses Gastric Cancer EMT and Metastasis by Attenuating TGF-β Pathway Through the Circ-OXCT1/miR-136/SMAD4 Axis</p>
... TGF- β /Smad pathway is a latent initiator of EMT, a process ends in tumor invasion and ...the SMAD-binding element, initiating gene ...suppressed TGF- β /Smad-induced EMT ...
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<p>G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer</p>
... In an in vitro assay, siRNA technology was used to effectively knock down the expression of G3BP1 in GC cell lines. Our fi ndings con fi rmed the outcomes of the study by Min et al, 5 which reported that C3BP1 is a potent ...
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Hyperglycemia promotes Snail-induced epithelial–mesenchymal transition of gastric cancer via activating ENO1 expression
... The TGF-β/Smad signaling pathway has a critical role in cancer development, and more importantly, it could also regulate EMT to promote cancer cell migra- tion, invasion and ...the ...
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Increased Smad3 and reduced Smad2 levels mediate the functional switch of TGF-β from growth suppressor to growth and metastasis promoter through TMEPAI/PMEPA1 in triple negative breast cancer
... the TGF-β - Smad - TMEPAI axis in promoting breast carcinogenesis, we studied relative contributions of Smad2 and Smad3 to the growth of breast cancer cells by altering endogenous Smad2 and Smad3 ...
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Asiatic Acid Isolated From Centella Asiatica Inhibits TGF-β1-induced Collagen Expression in Human Keloid Fibroblasts via PPAR-γ Activation
... with TGF-β/Smad signaling pathway in cancer ...antagonize TGF-β1’s effect on cancer growth and ...blocking TGF-β/Smad signaling into consideration[16], we postulated that ...
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Non-degradative ubiquitination in Smad-dependent TGF-β signaling
... in TGF-b signaling and to address its physiological function, we generated Smurf2-deficient ...to TGF- b, which has been shown to signal through cyclin- dependent kinases to control phosphorylation of T179 ...
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Effect of canonical NF-κB signaling pathway on the differentiation of rat dental epithelial stem cells
... signaling, TGF-β/SMAD sig- naling, p53 signaling, and PI3-Kinase/AKT pathway has been widely studied in the regulation of physiological and pathological processes ...
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Divergent signaling pathways cooperatively regulate TGFβ induction of cysteine-rich protein 2 in vascular smooth muscle cells
... and TGF β induction of the Csrp2 promoter activity It is evident from our studies that Smad2/3 and ATF2 par- ticipate in the TGFβ induction of ...potential Smad binding ele- ments (SBE), located at ...
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<p>Paeonol Inhibits Pancreatic Cancer Cell Migration and Invasion Through the Inhibition of TGF-β1/Smad Signaling and Epithelial-Mesenchymal-Transition</p>
... ameliorating TGF- β 1-induced PDAC cell migration, inva- sion and ...of TGF- β 1 effectively induced epithelial – mesenchymal transition and promoted PDAC cell migration and ...that ...
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