TGF-β type 2 receptor
TGF-β inhibits IL-1β-activated PAR-2 expression through multiple pathways in human primary synovial cells
... the TGF-β superfamily of ligands which include TGF-β s and BMPs, is vital for the homeostasis of numerous cellular functions, including cell growth, differentiation, and apoptosis in a broad ...
14
Type III TGF β receptor downregulation generates an immunotolerant tumor microenvironment
... These data suggested that TGFBR3 modulates the immune response to melanoma. Therefore, we used gene microarray analy- sis of resected human tumor tissues as well as ELISA analysis of the corresponding plasma samples of ...
17
Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5
... As shown above, depleting cells of PAR2 resulted in loss of Smad-dependent transcription (Figure 3) and Smad phosphorylation/activation (Figure 4). This result favors the idea that PAR2 promotes events upstream of Smad ...
15
The type III TGF β receptor suppresses breast cancer progression
... of the entire cytoplasmic domain of human TβRIII. The IgG fraction of pre-immune and immune rabbit serum was collected using Immuno- Pure IgG Purification kit (Pierce Biotechnology), and the specificity of the antibody ...
13
Regulation of TGF-β receptor activity
... including TGF- b , activin, Nodal, bone morphogenetic proteins (BMPs) and others, play vital roles in development, tissue homeostasis and some diseases development ...[1-3]. TGF- b signaling is initiated by ...
10
SKI2162, an inhibitor of the TGF-β type I receptor (ALK5), inhibits radiation-induced fibrosis in mice
... was significantly greater in the SKI2162 and tocopherol- pentoxifylline (PTX) treated groups than in the control group between 6 and 16 weeks post-irradiation. Early skin reactions were measured during the third and ...
9
TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
... (TGF-β1, TGF-β2 and TGF-β3) in mammals. All TGF-β precursor forms are secreted as latent homodimeric complexes, incorporated into the ECM, and activated by proteolytic cleavage ...All ...
20
Type III TGF β receptor promotes FGF2 mediated neuronal differentiation in neuroblastoma
... ChIP. ChIP analysis was performed using the ChIP-IT Express Chromatin Immunoprecipitation Kit (Active Motif) according to the manufacturer’s instructions. Briefly, chromatin was sheared (~500 bp average length) by ...
14
Modulation of cerebral endothelial cell function by TGF-β in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition
... However, TGF-β has also been implicated in angiogenesis in various model systems including physiological and pathological ...Direct TGF-β signalling on endothelial cells has been linked mainly ...
16
The interplay between TGF-β and VEGF signalling in endothelial cell function
... All TGF-β family ligands are generated as dimeric precursor proteins and subsequently cleaved by proteases and secreted ...the TGF-β family elicit their cellular effects by binding to a ...
177
Integrin mediated type II TGF β receptor tyrosine dephosphorylation controls SMAD dependent profibrotic signaling
... by 2 noncovalently associated α and β sub- ...specific receptor tyrosine kinas- es, or controlling the activation and levels of growth factors like TGF-β ...of TGF-β from ...
17
TGFβ signalling plays an important role in IL4-induced alternative activation of microglia
... the expression of Arg1 might partially be mediated by enhanced IL4Rα expression after TGFβ1 treatment, thereby increasing the sensitivity of microglia for IL4. IL4 signalling is further propagated by phosphorylation of ...
14
Urinary TGF-β1 was not independently associated with renal function in diabetes mellitus
... Methods: This was a cross-sectional study, and the samples were obtained using consecu- tive sampling technique. The study was performed on 99 subjects (62 DM normoalbuminuria patients, 27 DM albuminuria patients, and 10 ...
6
Distinct roles of Smad pathways and p38 pathways in cartilage specific gene expression in synovial fibroblasts
... Rabbit type II collagen and aggrecan probes were generously provided by Yoshiyasu Iwamoto (Thomas Jefferson University, Philadelphia, Pennsylvania, ...in 2× SSC for 15 min- utes at 42°C and then in ...
10
Rat testicular germ cells and sertoli cells release different types of bioactive transforming growth factor beta in vitro
... against TGF-β 1 (spermatocytes, round spermatids) and TGF-β 2 (elongating ...The TGF-β 1 antibody had a less pronounced inhibitory effect on the bioactivity in elongated ...
6
Loss of TGF β signaling contributes to autoimmune pancreatitis
... of TGF-β signaling leads to the presentation of autoantigens by these aberrantly expressed MHC class II molecules, thereby initiating the increased pro- duction of this array of cytokines and indicating Th ...
10
TGF β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
... Because TGF-β inhibits growth of epithelial cells, and carcinoma cells are often defective in TGF-β responses, any role of TGF-β in metas- tasis is likely to be mediated by ...
11
TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas
... It is well known that the epithelial–mesenchymal tran- sition (EMT) process plays an essential role in the inva- siveness and metastasis of various cancers [16, 17]. We therefore investigated whether TAGLN2 regulated EMT ...
14
Functional proteins of mesenchymal stem cell-derived extracellular vesicles
... coagulation, apoptosis, inflammation, and extracellular matrix remodeling. The absent proteins were mostly nu- clear proteins [49]. In an integrated transcriptomic and proteomic analysis of MSC-EVs derived from pig ...
11
Loeys-Dietz syndrome type I and type II: clinical findings and novel mutations in two Italian patients
... Results: Patient 1 was a boy showing dysmorphic signs, blue sclerae, high-arched palate, bifid uvula; skeletal system involvement, joint hypermobility, velvety and translucent skin, aortic root dilatation, tortuosity and ...
5