TGF-β1-induced
Oleanolic acid attenuates TGF β1 induced epithelial mesenchymal transition in NRK 52E cells
... process induced by TGF-β1 [35], and Nrf2 ac- tivation can restore the expression of klotho and then at- tenuates oxidative stress and inflammation in CKD ...by TGF-β1. The results ...
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Original Article UBE2T silencing inhibits TGF-β1-induced epithelial-to-mesenchymal transition in colon cancer cells
... and TGF-β1 treatment obviously induced the expression of UBE2Tin colon cancer ...inhibited TGF-β1-induced EMT process, as well as migration and invasion in colon cancer ...in ...
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Baicalin attenuates bleomycin-induced pulmonary fibrosis via adenosine A2a receptor related TGF-β1-induced ERK1/2 signaling pathway
... of TGF-β pathway, involving the TGF-β1-induced MAPK pathway [38, ...and TGF-β1- induced ERK1/2 pathway in pulmonary ...of TGF-β1 and phospho-ERK1/2 in KO ...
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/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region
... of TGF-β1-induced Smad3 activation and growth inhibition was due to enhanced phosphorylation of Smad3 linker region (pSmad3L) through activation of BLT1- NAD(P)H oxidase (NOX)-reactive oxygen species ...
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Original Article DIM attenuates TGF-β1-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts
... fibroblasts induced by transforming growth factor β1 ...blunted TGF-β1 induced conver- sion of cardiac fibroblast into myofibroblast, and reduced the mRNA and protein expressions of ...
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Original Article Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells
... as TGF-β1 con- tributes to the airway remodeling ...that TGF-β1 significantly increased ASMCs migration, whereas, apigenin significa- ntly suppressed TGF-β1-induced ASMCs ...
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Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling
... the TGF-β signalling pathways in the control of oncogenic cellular ...antagonized TGF-β1-induced growth inhibition and promoted cell migration in PDAC cells ...of ...
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Regulation of TGF-Β1-Induced Apoptosis and Epithelial-Mesenchymal Transition by Matrix Rigidity
... of TGF-β, we examined NMuMG and MDCK epithelial cells cultured on polyacrylamide gels with varying rigidity and treated with ...increased TGF-β1-induced apoptosis, while increasing matrix ...
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Tri-methylation of H3K79 is decreased in TGF-β1-induced epithelial-to-mesenchymal transition in lung cancer
... The best combination to partially reverse TGF-β1- induced EMT to a more epithelial phenotype was SAHA (a HDAC inhibitor) associated with a bromodomain in- hibitor. With this treatment, NRP2, SEMA3C, ...
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Effect of bradykinin on TGF-β1-induced retinal pigment epithelial cell proliferation and extracellular matrix secretion
... Proliferative vitreoretinopathy (PVR) is a complication that can follow rhegmatogenous retinal detachments. Proliferative membrane contraction can result in re- duced vision or blindness [1]. ECM deposition and cell ...
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Original Article Protocatechuic acid inhibits TGF-β1-induced proliferation and migration of human airway smooth muscle cells
... inhibited TGF-β1-induced ASMCs proliferation and migration, we examined the effect of PCA on the activation of TGF-β1/Sm- ad pathway using western ...4A, TGF-β1 treatment ...
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MiR-487a Promotes TGF-β1-induced EMT, the Migration and Invasion of Breast Cancer Cells by Directly Targeting MAGI2
... factor β1 (TGF-β1) significantly increased the expression of miR-487a in MCF-7 and MDA-MB-231 breast cancer ...and TGF-β1 induced the in- creased miR-487a promoter activity via ...
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TGF-β1-induced differentiation of SHED into functional smooth muscle cells
... of TGF- β signaling is triggered through the binding of TGF- β cytokines to their cognate receptors (TGF- β RI and ...activated TGF- β RI recruits and phosphorylates Smad proteins, ...for ...
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Original Article Characteristics of core fucosylation changes of TGF-β1-induced pericyte tranformation in mouse lungs
... by TGF-β1, the pericyte morphology transformed from a multi-star shape into a fusiform myofibroblast ...with TGF-β1 for 24 h, some of the cells began to stretch and separate from peripheral ...
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mir 106b 5p targeting SIX1 inhibits TGF β1 induced in asthma through regulation of E2F1
... Ovalbumin (OVA)‑induced murine asthma model. A total of 10 BALB/c male mice (6 weeks old; 18‑20 g), obtained from Beijing Vital River Laboratory Animal Technology Co. Ltd. Mice were housed in plastic boxes with a ...
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Effects of PPARγ ligands on TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells
... [5,13-15]. TGF-b1 treatment has been shown to alter the cell mor- phology of the human AECII derived A549 cell line from cobblestone-shaped to a fibroblastoid appearance ...of TGF-b1 on fibroblast ...
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TGF β1–induced expression of human Mdm2 correlates with late stage metastatic breast cancer
... to TGF-β1, 2 possible binding elements in the promoter conformed to the GTCT Smad3 DNA–binding element ...after TGF-β1 exposure at times when Hdm2 levels were ...to TGF-β1 formed ...
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YY1 mediates TGF-β1-induced EMT and pro-fibrogenesis in alveolar epithelial cells
... The distribution of NF- κ B in the cytoplasm and the nucleus were further examined (Fig. 4c). The transloca- tion of NF-κB p65 from the cytoplasm to the nucleus was observed after EMT induction by either YY1 overex- ...
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Original Article Effect of CTRP3 on activation of adventitial fibroblasts induced by TGF-β1 from rat aorta in vitro
... demonstrated TGF-β1 could induce fibroblasts into myofibroblasts by stimu- lating α-SMA expression [39] and promoting the secretion of ECM proteins, which have been found to play a vital role in the process ...
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A-Kinase Anchoring Proteins Diminish TGF-β1 / Cigarette Smoke-Induced Epithelial-to-Mesenchymal Transition
... Role of Ezrin, AKAP95 and Yotiao in TGF-β1-induced cell migration using BEAS-2B cells. 361[r] ...
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