TGF-β1-induced protein
Original Article MicroRNA-142-3p inhibits high-glucose-induced endothelial-to-mesenchymal transition through targeting TGF-β1/Smad pathway in primary human aortic endothelial cells
... the protein level of the endothelial markers VE-cadherin and CD31 and inhibited HG-induced EndMT in ...EndMT. TGF-β1 has been found to be one of the molec- ular mediators involved in the ...
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Original Article Knockdown of ANGPTL2 reduces transforming growth factor-β1-induced fibrogenesis in cardiac fibroblasts
... Total proteins were extracted using RIPA lysis buffer (Beyotime, Jiangsu, China), and the pro- tein concentration was determined by BCA pro- tein assay kit (Pierce, Rockford, USA). Equal amounts of proteins (30 μg per ...
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Original Article Characteristics of core fucosylation changes of TGF-β1-induced pericyte tranformation in mouse lungs
... in TGF-β1 24 h group and shape of 80% of the pericytes changed from a multi-star shape to a long strip shape in TGF-β1 48 h (Figure ...that TGF-β1 may be the factor caus- ing the ...
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Original Article Peroxiredoxin-1 attenuates hepatic fibrosis by inhibiting TGF-β1/Smad3 and ROS signal pathways
... factor β1 (TGF-β1) makes a major contribution to the development of hepatic fibrosis in response to increases in intracellular reactive oxygen species ...the TGF-β1 action in the above ...
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Original Article Spatial and temporal expression of SP-B and TGF-β1 in hyperoxia-induced neonatal rat lung injury
... injury induced by pulmonary hypoplasia or in- fection reduced SP-B expres- sion, while lung injury induced by hyperoxia increased SP-B expression, providing an op- portunity for use SP-B as a biomarker ...
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MicroRNA-21 promotes TGF-β1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression
... The protein expressions of PTEN, Akt and p-AKT was tested by PV-9000 two-step ...PTEN protein was presented in yellow brown in cytoplasm and the positive expression of Akt protein was yellow brown or ...
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Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF β/miR 195/Smad signaling pathway
... cycle protein D ...when induced by interferon-B, miR-195 level increased and interferon-B could inhibit LX-2 proliferation by down-regulating cyclin-E1 [26], these results indicated that the effect of ...
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Original Article TGF-β1 induces airway smooth muscle cell proliferation and remodeling in asthmatic mice by up-regulating miR-181a and suppressing PTEN
... factor β1 (TGF-β1) plays a crucial role in remodeling and proliferation of airway smooth muscle cells ...studied. TGF-β1 can up-regulate the level of miR-181a in multiple cells, while ...
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Rapamycin Inhibits Transforming Growth Factor β1 Induced Fibrogenesis in Primary Human Lung Fibroblasts
... as protein phosphatase 2A or protein kinase C δ affect collagen type III and fibronectin synthesis or not? Fur- ther experiments are needed to clarify ...in TGF-β1- induced ...of ...
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Human cytomegalovirus promotes the activation of TGF-β1 in human umbilical vein endothelial cells by MMP-2 after endothelial mesenchymal transition
... activated TGF-β1 decreased by 60% when the HUVECs were treated with GM6001 (p < ...activated TGF-β1 decreased by 9% when the HUVECs were treated with aprotinin (p > ...activated ...
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Herbal compound 861 prevents hepatic fibrosis by inhibiting the TGF β1/Smad/SnoN pathway in bile duct ligated rats
... In the sham operation group, there was normal lobular architecture with central veins, radiating hepatic cords, and no regenerated collagen fibers (Fig. 1). In contrast, livers from the BDL group showed collagen fibers, ...
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Original Article DIM attenuates TGF-β1-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts
... the protein concen- trations were determined with the BCA protein assay reagent (Thermo, ...Specific protein expres- sion levels were normalized to the GAPDH pro- tein level which contained total ...
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Blocking Smad7 restores TGF β1 signaling in chronic inflammatory bowel disease
... Smad7 protein in fibroblast cell lines ...between TGF- β 1 and IFN- γ /TNF- α in the regulation of immune cell functions in the gut ...be induced by several locally produced molecules, it is possible ...
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TGF-β1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways
... of TGF-β1 and its receptors has been reported to correlate with metastasis of human cancers and reduced survival ...Although TGF-β1 has been shown to regulate PTEN expression through various ...
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Original Article Inhibition of the TGF-β/Smads signaling pathway attenuates pulmonary fibrosis and induces anti-proliferative effect on synovial fibroblasts in rheumatoid arthritis
... of TGF-β1 in RA + PF patients, RA patients and healthy controls were ...fully induced and assigned into groups. The mRNA, phosphorylation and protein expressions of TGF-β1, Smad2 ...
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Original Article TGF-β promotes invasion and angiogenesis of oral squamous cell carcinoma SCC9 cells by upregulation of slug signal
... 3. TGF-β-induced Slug promotes the migration, invasion and angiogenesis of SCC9 ...Slug protein expression was detected by western blot assay; B, ...
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Label-free quantitative proteomics identifies transforming growth factor β1 (TGF-β1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells
... successfully induced the adipogenic trans- formation of OP9-DL1 cells into adipocytes by using ...binding protein, is primarily expressed in macrophages and adi- pocytes and regulates fatty acid storage and ...
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Distinct mechanisms of TGF β1–mediated epithelial to mesenchymal transition and metastasis during skin carcinogenesis
... overexpress TGF-b 1 but exhibit decreased expression of the TGF-b type II receptor ...of TGF-b 1 in keratinocytes expressing a dominant negative TGF-bRII (ΔbRII) in the ...expression, ...
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TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5
... with TGF-β1 for the indicated durations, and cell lysates were then pre- ...on TGF-β1- induced SMAD2 phosphorylation were examined by SB431542 pretreatment for 30 min followed by ...
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A-Kinase Anchoring Proteins Diminish TGF-β1 / Cigarette Smoke-Induced Epithelial-to-Mesenchymal Transition
... Role of Ezrin, AKAP95 and Yotiao in TGF-β1-induced cell migration using BEAS-2B cells. 361[r] ...
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