The anaphase promoting complex (APC)
The Anaphase-Promoting Complex/Cyclosome Is Required for Anaphase Progression in Multinucleated Ashbya gossypii Cells
... The anaphase-promoting complex/cyclosome (APC/C) is responsible for the protein destruction required for the initiation of anaphase and the exit from mitosis, including the degradation of ...
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Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).
... The anaphase promoting complex or cyclosome (APC/C) is a multi-subunit cullin-RING E3 ubiquitin ligase that functions to regulate progression through the mitotic phase of the cell cycle and to ...
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Control the Host Cell Cycle: Viral Regulation of the Anaphase-Promoting Complex
... ligase anaphase-promoting complex (APC) that targets effector proteins for ubiquitination and proteasome ...through anaphase, exit from mitosis, and prevent a premature entry into S ...
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Understanding Structural And Functional Mechanisms of Emi1 Inhibition of the Anaphase Promoting Complex
... the Anaphase Promoting Complex, also called Cyclosome (APC/C), modifies myriad substrates that control cell cycle ...ligase complex; it is the final enzyme in a tri-enzyme cascade and ...
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Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome
... The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit, multifunctional ubiquitin ligase that controls the temporal degradation of numerous cell cycle regulatory proteins to direct the ...
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emb-1 Encodes the APC16 Subunit of the Caenorhabditis elegans Anaphase-Promoting Complex
... Diane C. Shakes,* Anna K. Allen, † Kelsey M. Albert,* and Andy Golden †,1 *Department of Biology, College of William and Mary, Williamsburg, Virginia, and † Laboratory of Biochemistry and Genetics, National Institute of ...
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Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast
... Azharul Islam, Emma L Turner, Johannes Menzel, Mackenzie E Malo and Troy AA Harkness * Abstract Background: Histone post-translational modifications are critical for gene expression and cell viability. A broad spectrum ...
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Nuclear pore protein NUP88 activates anaphase promoting complex to promote aneuploidy
... We determined that NUP88 and the nuclear transport factors NUP98 and RAE1 comprise a regulatory network that inhibits premitotic activity of the anaphase-promoting complex/cyclosome (APC/C). When ...
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The Anaphase Promoting Complex Regulates Yeast Lifespan and rDNA Stability by Targeting Fob1 for Degradation
... HE anaphase promoting complex (APC) is a ubiquitin- protein ligase (E3) that is conserved from yeast to hu- mans (Harper et ...the anaphase/metaphase junction (Zachariae and Nasmyth ...
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The Anaphase Promoting Complex Contributes to the Degradation of the S. cerevisiae Telomerase Recruitment Subunit Est1p
... Telomerase is a multi-subunit enzyme that reverse transcribes telomere repeats onto the ends of linear eukaryotic chromosomes and is therefore critical for genome stability. S. cerevisiae telomerase activity is ...
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A Functional Analysis Reveals Dependence on the Anaphase-Promoting Complex for Prolonged Life Span in Yeast
... in anaphase-promoting complex (APC) activity, which regulates mitotic progression and chroma- tin assembly, results in genomic instability, a hallmark of premature aging and ...
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Downregulation of the anaphase promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships
... The anaphase-promoting complex (APC) is a multiprotein complex with E3 ubiquitin ligase activity, which is required for the ubiquitination of securin and ...
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Multiple Subunits of the Caenorhabditis elegans Anaphase-Promoting Complex Are Required for Chromosome Segregation During Meiosis I
... Manuscript received September 5, 2001 Accepted for publication December 6, 2001 ABSTRACT Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove ...
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Changes in the Localization of the Saccharomyces cerevisiae Anaphase-Promoting Complex Upon Microtubule Depolymerization and Spindle Checkpoint Activation
... The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase in the ubiquitin-mediated proteolysis pathway ...late anaphase, the Cdc23-GFP was also visualized along the length of ...
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Regulation of Glia Number in Drosophila by Rap/Fzr, an Activator of the Anaphase-Promoting Complex, and Loco, an RGS Protein
... Glia mediate a vast array of cellular processes and are critical for nervous system development and function. Despite their immense importance in neurobiology, glia remain understudied and the molecular mechanisms that ...
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The Ama1-Directed Anaphase-Promoting Complex Regulates the Smk1 Mitogen-Activated Protein Kinase During Meiosis in Yeast
... ABSTRACT Smk1 is a meiosis-specific MAPK homolog in Saccharomyces cerevisiae that regulates the postmeiotic program of spore formation. Similar to other MAPKs, it is activated via phosphorylation of the T-X-Y motif in ...
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Timing of anaphase promoting complex activation in mouse oocytes is predicted by microtubule kinetochore attachment but not by bivalent alignment or tension
... SUMMARY Homologous chromosome segregation errors during meiosis I are common and generate aneuploid embryos. Here, we provide a reason for this susceptibility to mis-segregation by live cell imaging of mouse oocytes. Our ...
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Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase promoting complex/cyclosome
... Asymmetric cell divisions generate cell fate diversity during both invertebrate and vertebrate development. Drosophila neural progenitors or neuroblasts (NBs) each divide asymmetrically to produce a larger neuroblast and ...
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The E3 ligase Cdh1 anaphase promoting complex operates upstream of the E3 ligase Smurf1 in the control of axon growth
... *Author for correspondence ([email protected]) Accepted 11 July 2012 SUMMARY Axon growth is an essential event during brain development and is extremely limited due to extrinsic and intrinsic inhibition in the adult ...
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Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma
... ABSTRACT: Osteosarcoma is the most common primary malignant bone tumor in childhood and adolescence and has a propensity for local invasion and early lung metastasis. However, the current therapies often result in ...
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