The bone marrow microenvironment
Chemokines as a conductor of bone marrow microenvironment in chronic myeloid leukemia
... in bone marrow after ...and bone marrow ...by bone marrow microenvironments including niche, as HSCs ...with bone marrow microenvironments is indispensable for the ...
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Pretreatment with antioxidants prevent bone injury by improving bone marrow microenvironment for stem cells
... induces bone injury by producing free radicals that adversely affect the stem cell microenv- ironment for MSCs while damaging bone marrow blood vessels ...Improving bone marrow ...
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Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment
... the bone marrow microenvironment Kovtonyuk, L V ; Fritsch, K ; Feng, X ; Manz, M G ; Takizawa, H Abstract: All hematopoietic and immune cells are continuously generated by hematopoietic stem cells ...
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Micro-RNAs, New performers in multiple myeloma bone marrow microenvironment
... and bone marrow microenvironment components provides malignant cells with various survival, growth and drug resistance ...of bone marrow microenvironment will help understanding ...
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Acute myeloid leukaemia in its niche: the bone marrow microenvironment in acute myeloid leukaemia
... Osteoclasts and Osteoblasts The endosteum is lined by osteoblasts and osteoclasts, which regulate bone formation and resorption and form an important part of the bone marrow microenvironment. ...
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Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment
... the bone marrow microenvironment Amina M Abdul-Aziz 1* , Yu Sun 1* , Charlotte Hellmich 1* , Christopher R Marlein 1 , Jayna Mistry 1 , Eoghan Forde 1 , Rachel E Piddock 1 , Manar S Shafat 1 , Adam ...
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Hedgehog inhibitors selectively target cell migration and adhesion of mantle cell lymphoma in bone marrow microenvironment
... migration, bone marrow microenvironment, hedgehog Received: November 02, 2015 Accepted: January 29, 2016 Published: February 11, 2016 ABSTRACT The clinical benefits of a Hedgehog (Hh) inhibitor, ...
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Chronic myelogenous leukaemia exosomes modulate bone marrow microenvironment through activation of epidermal growth factor receptor
... in bone marrow microenvironment and that AREG is involved in the activa- tion of EGFR downstream signalling in mesenchymal stromal cells leading to the expression and release of IL8 and other ...
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The bone marrow microenvironment – Home of the leukemic blasts
... the bone marrow ...BM microenvironment in sustaining ...complex microenvironment of the BM, which is known to be a key player in the pathogenesis of the ...BM microenvironment is ...
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Investigating the role of the bone marrow microenvironment in multiple myeloma
... 111 5.1 Introduction 5.1.1 Autophagy is the cellular way of protection To further understand how BMSC protect MM cells I next explored if autophagy in the BMSC is activated in response to MM coculture. MM have been shown ...
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Bone Marrow Microenvironment-mediated Resistance to Chemotherapy in Leukemia
... tumor microenvironment by targeting the SDF-1α/CXCR4 axis with SDF-1α antibodies, CXCR4-neutralizing antibodies, or the CXCR4 inhibitor plerixafor (AMD3100) (34) significantly decreases their survival and/or ...
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The effect of bone marrow microenvironment on the functional properties of the therapeutic bone marrow derived cells in patients with acute myocardial infarction
... the bone marrow HCO 3 level below the median value experienced a more marked improvement of LVEF after stem cell treatment than their counterparts with an HCO 3 level above the median ...
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Extracellular vesicle cross-talk in the bone marrow microenvironment: implications in multiple myeloma
... Perspectives Although compelling studies have focused on the targets and functions of EVs secreted by many BM-derived cells and on the important role of EVs in the immune response, tumor progression, vaccine development, ...
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Intercellular mitochondrial transfer in the bone marrow microenvironment of acute myeloid leukaemia and multiple myeloma
... in bone marrow niches, where they are protected from chemotherapeutics and have the ability to proliferate - leading to the repopulation of the ...the bone marrow will provide a better ...
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The Yin and Yang of the Bone Marrow Microenvironment: Pros and Cons of Mesenchymal Stromal Cells in Acute Myeloid Leukemia
... immune-tolerant microenvironment able to support the survival of leukemic cells and affect the response to ...emerging microenvironment-driven mechanisms conferring a survival advantage to leukemic cells ...
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In vivo hematopoietic Myc activation directs a transcriptional signature in endothelial cells within the bone marrow microenvironment
... mouse bone marrow transduction/transplantation model where the conditional activation of the oncoprotein Myc expressed in the hematopoietic system could be assessed for influencing the host ...
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Involvement of urokinase receptor in the cross-talk between human hematopoietic stem cells and bone marrow microenvironment
... LTCs, at present, represent the best surrogate in vitro of BM hematopoiesis in vivo, because they mimic the complex intercellular interactions between the stromal microenvironment and stem cells concentrated in ...
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The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells
... the bone marrow (BM) microenvironment by regulating angiogenesis, cytokine release, immune response, inflammation, and ...between bone marrow stromal cells (BMSCs) and multiple myeloma ...
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Regulation of Mcl-1 Expression in Context to Bone Marrow Stromal Microenvironment in Chronic Lymphocytic Leukemia
... † Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX Abstract A growing body of evidence suggests that the resistance of CLL cells to apoptosis is partly mediated through the ...
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Role of Bone Marrow-Derived Mesenchymal Stem Cells Differentiate into β Cells in the Pancreatic Microenvironment
... 5. CONCLUSION The authors transplanted BM-MSCs derived from male SD rats into diabetic female SD rats and showed that MSCs survived, and expressed insulin as well as genes associated with beta-cell development. Glycemic ...
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