The Disease Specific Model
TIA1 is a gender-specific disease modifier of a mild mouse model of spinal muscular atrophy
... mouse model. While there are a few reported SMA disease modifiers, only Plastin3 has thus far been shown to be gender specific 44 ...the disease modifying role of TIA1 in SMA by employing the ...
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Subject-specific multiporoelastic model for exploring the risk factors associated with the early stages of Alzheimer's disease
... MPET-based model of cerebral parenchyma; an accurate, fully automated image-based model personalization work- flow; and a subject-specific boundary condition ...
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Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease
... identified specific lipid species that are altered within the corresponding groups, allowing for a thor- ough, quantitative comparison between the PLB WT and PLB4 mouse brain ...
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Disease Mention Recognition with Specific Features
... This observation is reasonable because gene/protein names are much more complex than entities such as diseases. For example, they often contain punctuation characters (such as paren- theses or hyphen), Greek alphabets ...
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Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
... the specific bacteria and viruses ...a model in which IBD- associated increases in bacteriophage richness are not merely accounted for by an increase in their bacterial host ...to disease ...
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Subject-specific multi-poroelastic model for exploring the risk factors associated with the early stages of Alzheimer's disease
... MPET-based model of cerebral parenchyma; an accurate, fully automated image-based model personalization work- flow; and a subject-specific boundary condition ...
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Anti Aβ42– and anti Aβ40–specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model
... Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, Jacksonville, Florida, USA. Accumulation and aggregation of amyloid β peptide 1–42 (Aβ 42 ) in the brain has been hypothesized as trig- gering a ...
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HPV16-specific cellular immunity in health and disease
... Chapter 6 126 environment also lacks proinflammatory cytokines. Imiquimod is known to directly stimulate Langerhans cells and macrophages 17,47 , of which the latter are increased in VIN lesions 42 . Furthermore, it ...
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Can glypican-3 be a disease-specific biomarker?
... GPC3 was identified by integrating proteomic profiles of inflammatory mediators with clinical bioinformatics [7]. In the research by Chen et al., plasma was collected from the healthy persons as controls or from patients ...
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Celiac disease: pathogenesis of a model immunogenetic disease
... “gluten” peptides into a microenvironmental milieu in the small- intestinal mucosa suited for disease development is facilitated by a transient infection or other cause of inflammation in the small intestine. ...
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Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease
... a specific inhibitor of its phosphatase, elevates BACE1 levels in younger 5XFAD mice, which have not yet showed BACE1 upregulation at basal levels concomitant with only marginal increases in eIF2a phosphorylation ...
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A multimodal RAGE specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease
... Discussion Screening a second-generation library of small compounds that were synthesized based on the common structural features of the lead tertiary amides from an initial primary screen, we have iden- tified a ...
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The effects of Rhes, a striatal specific protein, on the expression of behavioral and neuropathological symptoms in a transgenic mouse model of Huntington's disease
... the disease, akinesia (slowed initiation of movement), bradykinesia (slowness in the execution of movement), and dystonia (abnormal posture) can also be prevalent (Rosas, Salat, Lee, Zaleta, Pappu, Fischl et ...
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Highly interconnected genes in disease specific networks are enriched for disease associated polymorphisms
... optimal model of complex diseases in that it has a clearly defined phenotype that occurs at a given time point each year and the external cause (pollen) and key cell-type (lymphocytes) are known (Extended ...
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Human-specific CpG "beacons" identify loci associated with human-specific traits and disease.
... Figure 5. Model for beacon-mediated cGI evolution and example for possible association with disease. The left panel illustrates a model for cpG beacon-mediated increase of cpG density. a moderate cpG ...
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Disease Specific Nutrition
... Corn maltodextrin, sugar (sucrose), partially hydrolysed protein blend (soy and collagen), whey protein concentrate, whey protein hydrolysate, safflower oil, Medium Chain Triglyceride[r] ...
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Disease-Specific Care
... Rationale: Cigarette smoking is the single most alterable risk factor contributing to premature morbidity and mortality, accounting for approximately 430,000 deaths in the United States. Smoking nearly doubles the risk ...
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Appendix A: Disease-Specific Chapters
... Canada has achieved its goal of measles elimination, and endemic transmission of measles has been interrupted by high two-dose vaccine coverage as a part of routine infant and childhood immunization programs. However ...
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Specific CT Findings in Krabbe Disease
... Specific computed tomography (CT) findings in four patients with biochemically proven Krabbe disease included symmetric increased attenuation in the cerebellum, brain[r] ...
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GASTRIC RESPONSE TO SPECIFIC DISEASE IN INFANTS
... Conversely, the few infants with cyanotic congenital heart disease studied had de- creased volume of gastric juice and rate of acid formation. REFERENCES[r] ...
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