The DNA Damage Response
Autophagy in DNA Damage Response
... the DNA damage induced by IR and two anticancer agents, camptothecin and etoposide, compared to the wild-type cells ...regulates DNA damage response by autophagy and regulation of ...
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A Synthetic Circuit For Control Of The Bacterial Dna Damage Response Without Dna Damage
... SOS DNA damage response without a requirement for DNA ...following DNA damage and RecA* ...NTD DNA-binding and CTD protease activities while acquiring the novel function ...
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The Smc complexes in DNA damage response
... mediate DNA repair are not ...their DNA repair functions are separ- able from their major functions in sister-chromatid cohesion and chromosome ...the DNA repair func- tions of the Smc complexes are ...
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Ciliogenesis and the DNA damage response: A stressful relationship.
... the DNA damage response (DDR), and genome stability mechanisms involve a complex net- work of signalling and processing factors that ensure redundancy and adaptability of these ...
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ATP-dependent chromatin remodeling in the DNA-damage response
... of DNA is continuously challenged by metabolism-derived and environmental genotoxic agents that cause a variety of DNA lesions, including base alterations and ...breaks. DNA damage interferes ...
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Sak and its potential role in the DNA damage response.
... and DNA damage ...in DNA damage pathways and found that full length wild-type Sak protein was found to be subjected to phosphorylation both in the presence and absence of ...key DNA ...
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Role of NEDD8 and neddylation dynamics in DNA damage response
... Timely DNA damage response is essential for ...of DNA-damage signaling leads to dynamic CRL–CSN complex assembly and disassembly to orches- trate DRR-related protein ubiquitylation by ...
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Relationship between DNA damage response and telomere maintenance
... defective DNA damage ...defective DNA damage response due to mutations in the ATM (AT mutated) gene (Metcalfe et ...of DNA damage response defects have been ...
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PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis
... in DNA damage signaling and response, but the crucial mechanism remains ...the DNA damage response induced by ionizing radiation (IR) was investigated in multiple cell lines with ...
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Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response
... fetal DNA integrity and DNA damage response ...to DNA damage and apoptosis induction compared to fetal blood ...in DNA repair mechanisms, especially in the BER ...adaptive ...
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Development and validation of an assay for the characterization of the DNA damage response to damage caused by superfund chemicals
... the DNA damage response to formaldehyde – a chemical shown to induce ...the response of our DT40 system to another, completely different sort of chemical, the inorganic salt of the metal ...
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DDX54 regulates transcriptome dynamics during DNA damage response
... cellular response to genotoxic stress is mediated by a well-characterized network of DNA surveillance ...the DNA damage response (DDR) has not been extensively ...
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A role of SUMOylation in proteostasis, centromere integrity and the DNA damage response
... the DNA damage response 76,77 ...the DNA damage response and reflect the importance of reversible ubiquitination of SUMOylated proteins 65-67,78,79 ...
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PHD3 dependent hydroxylation of HCLK2 promotes the DNA damage response
... 1 UNC McAllister Heart Institute and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA. 2 Departments of Structural Biology and Developmental Neurobiology, St. Jude Proteomics ...
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Radiation therapy induces the DNA damage response in peripheral blood.
... kinase-dependent DNA damage response in the peripheral blood is unprecedented and promotes the use of ATM serine-1981 phosphorylation as a predictive biomarker for DNA damaging modalities and ...
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Functions of DNA Damage Response Factors in Lymphocyte Development and Transformation
... between DNA damage response factors likely depend on the cellular ...how DNA damage and repair factors coordinately regulate V(D)J recombination, lymphocyte development and neoplastic ...
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Physical and in silico approaches identify DNA PK in a Tax DNA damage response interactome
... in DNA damage response (Rad51, TOP1, Chk2, ...proteins, DNA-PK was the highest ranked protein common to both ...showed DNA-PK to be one of three bridge proteins that link multiple ...
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Multiple Roles of BRIT1/MCPH1 in DNA Damage Response, DNA Repair, and Cancer Suppression
... of DNA repair 51,52 Our very recent study reports a novel func- tion of BRIT1 as a regulator of ATP-dependent chromatin remodeling complex SWI/SNF in DNA ...Upon DNA damage, BRIT1 increases ...
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Inflammation contributes to NKX3.1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression
... the DNA damage response may not be ...examined DNA damage, the subsequent acti- vation of SIRT1 and the DNA damage ...
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DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway
... the DNA damage response is essential for advancing cancer ...and DNA damage-induced chromosomal ...FA DNA repair pathway will identify novel factors that can be specifically ...
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