The fragment-based approach
Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach
... a fragment-based synthetic ...our fragment-based approach com- pared to an average 89% yield per cycle when a monomeric coupling approach is ...a fragment-based ...
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Fragment Based Approach to Forecast Association Rules from Indian IT Stock Transaction Data
... rules. Fragment Based approach works on overcoming the drawbacks of FITI approach which groups the transactions instead of considering all the transactions from the stock ...
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A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
... comprehensive fragment-based inhibitor exploration of an HSP70 enzyme, which yielded an amino-quinazoline fragment that was elaborated to a novel ATP binding site ligand with different ...
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A Fragment-Based Approach for Efficiently Creating Dynamic Web Content
... single fragment that is included in multiple pages is triggered; the pages that need to be built as a result of the change to the fragment are determined from the ...
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Business Process Collaboration: A Fragment-based Approach using Connectors
... new approach based on process ...process fragment as an independent part of ...this approach investigates this issue by adopting the notion of connectors in order to increase the reusability ...
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Predicting drug side-effect profiles: a chemical fragment-based approach.
... The proposed method is expected to be useful in var- ious ways and at various stages of the drug development process. At early stages, among several active drug can- didates, the method could help to choose the molecules ...
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Fast, efficient fragment-based coordinate generation for Open Babel
... In this work, we discuss an open source implementa- tion of a new fragment-based approach for coordinate generation in Open Babel, with improved accuracy and performance. We compare the ...
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Fragment-based lead discovery on G-protein-coupled receptors
... applying fragment-based drug discovery are specific identification of substantially lower affinity on-target interactions and assessment of development propensity of low complexity ...out based on ...
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The application of the fragment based screening approach to RmlA protein and PA1645 structure
... (DSF) approach to detect ligands that bind and stabilize RmlA ...DSF approach with an overview of the key advantages of the technique and where it stands compared to other fragment screening ...
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New approach for Effective Query Recommendation: Context Aware Fragment Based Method
... AWARE FRAGMENT BASED METHOD Fragments are the predefined structures used in a query language ...Each fragment is identified using begin and end ...aware fragment based system both the ...
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DeepFrag-k: A Fragment-Based Deep Learning Approach for Protein Fold Recognition
... for fragment prediction As shown in [ 28 ], the top-100 Frag-k fragments are capable of classifying major SCOP folds in high accuracy and can also be used to assemble most protein structures in high ...the ...
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FRAGMENT-BASED LEAD DISCOVERY
... established approach for hit identification within the pharmaceutical ...discovery. Fragment- based approaches offer a number of attractive features compared with ...a fragment hit are ...
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Drug discovery in cancer research: hit identification using a fragment-based by NMR approach
... this approach, it is possible in the first place to produce large amounts of protein, and also to express proteins enriched with 13 C and 15 N using specific media containing 15 NH 4 Cl as sole nitrogen source, ...
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A Novel Approach for Secure Image Transmission Based on Secret-Fragment-Visible Mosaic Images
... The feasibility of the proposed method is supported with good experimental results. KEYWORDS: Mosaic image, image security, color transformations, image encryption, data hiding, lossless I. I NTRODUCTION Image ...
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Media fragment semantics: the linked data approach
... Media Fragment Enrichment, which reuses W3C-MFURI, W3C-MA, NinSuna Ontology, Open Annotation Core Model and Prove- nance Ontology, to model the media fragments and their relationships with resources in the LOD ...
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Improved approaches to ligand growing through fragment docking and fragment-based library design
... core fragment for further synthesis. Secondly, our approach for fragment growing is based on the assumption that each individual building block should engage in favorable interactions with the ...
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Activity-Directed Fragment-Based Ligand Discovery
... structure- based drug design ...empirical approach of design, synthesis and testing usually all takes place in isolation from assessment of function, meaning that equal resources and time are spent on all ...
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Fragment reweighting in ligand-based virtual screening
... factors; fragment reweighting is the process of adding new weight to the original weight in order to improve retrieval performance in information retrieval ...important fragment and using the idea of ...
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Fragment-based QSAR: perspectives in drug design
... in fragment-based QSAR as an important tool in drug design [ 20 , 21 , 31 – 42 , 46 , 62 ...interest based on knowledge of the chemical structure ...spective, fragment-based HQSAR, ...
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Using fragment-based approaches to discover new antibiotics
... the approach, 50 and there have recently been significant improvements in streamlining data collec- tion and structure ...a fragment binding to a protein even when it has been confirmed to bind by other ...
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