The HLA class I antigen processing pathway
Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells
... of HLA class II an- tigen processing and presentation by ...express HLA-DR molecules, we demonstrate the restricted expression of HLA class II antigens at the basolateral surface ...
13
Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing
... of HLA class II molecules constitutively, with elevated levels seen in the set- ting of mucosal inflammation including inflammatory bowel ...the HLA class II antigen processing ...
13
beta2 Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma
... that HLA class I antigen loss transpires early in tumor progression and that increased exposure to tumor vasculature results in selection of HLA class I negative tumor ...
11
HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status
... in HLA expression, we looked at murine xenografts that were obtained by injection of three CM cell lines into the subconjunctiva of NOD/SCID-mice (with impaired T, B, and NK ...low HLA class I ...
11
Human histocompatibility leukocyte antigen (HLA) haplotype frequencies estimated from the data on HLA class I, II, and III antigens in 111 Japanese narcoleptics
... K Matsuki, … , M Satake, Y Honda J Clin Invest. 1985;76(6):2078-2083. https://doi.org/10.1172/JCI112211. In order to deduce the predominant haplotypes in Japanese narcoleptics, we have studied a total of 111 Japanese ...
7
A novel role of HLA class I in the pathology of medulloblastoma
... MHC class I processing machinery was analyzed in greater detail, by examining expression of HLA heavy and light chains and TAP2 ...MHC class I processing, were ...for ...
13
Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients
... of HLA on the surface of tumor cells has been observed in various types of human malignancies, including cHL ...of HLA antigen by tumor cells is quite common in EBV-neg cHL, since ...expressed ...
6
Melanosomes and MHC Class II Antigen-Processing Compartments
... biosynthetic pathway to the endosomal system, the role of the transport machinery in establishing these routes, and the mechanisms by which tumor antigens are presented to the T cell arm of the immune ...MHC-II ...
17
Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity.
... Leukocyte Antigen class I (HLA-I) binding motifs plays a central role in our ability to understand and predict (neo-)antigen presentation in infectious diseases and ...of ...
28
Killer immunoglobulin like receptors/human leukocyte antigen class I, a crucial immune pathway in cancer
... complex class-I (MHC class-I), which is also called human leukocyte antigen class-I (HLA ...of HLA class-I and inhibitory KIRs could inhibit NK ...
5
Lack of HLA class I antigen expression by cultured melanoma cells FO 1 due to a defect in B2m gene expression
... express HLA class I antigens and does not acquire them on the cell surface after incubation with ...synthesize HLA class I heavy chain, but do not synthesize beta ...
10
Investigating the role of HLA class I derived peptide in alloreactivity
... maintain HLA-E expression at the cell surface by mimicking HLA class I leader peptide sequences (Mazzarino et a i, 2005) and those utilized by CMV have a high affinity for HLA-E ...
222
Expression, purification and characterization of ricin vectors used for exogenous antigen delivery into the MHC class I presentation pathway
... In order to characterize the chimera, both the early fractions (4-12), containing predominantly the higher band, and the later fractions (14-22) were separately pooled and concentrated. The proteins were dialysed into a ...
7
IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells
... surface HLA class I expres- sion by ...because: i) pre-stimulation with sIL-6R/IL-6 followed by removal shortly before IL-27 stimulation failed to interfere with HLA class ...
12
HLA class II restricted minor histocompatibility antigens - identification, processing and biology
... of HLA class II epitopes has been further confirmed by our T-cell library experiments as well as an earlier mouse study, 31 showing that at least a quarter of undefined self-antigens in natural T-cell ...
191
Investigation of Human Leukocyte Antigen (HLA) Class I and II Alleles and Hepatitis C Virus (HCV) Genotypes in Patients Infected with HCV
... The HLA class I B*38 allele group was more prone to develop chronic hepatitis C (P< ...Also, HLA-DRB1*11, DRB3 and DQB1*03 had significantly higher association with subjects with self limiting ...
11
Antigen Processing
... cla class ss II II MH MHC C mo molec lecule ules s is is eit either her con consti stitut tutive ive or or ind induc ucibl ible, e, esp especi eciall ally y by by interferon-g interferon-gamma in the case of mac ...
7
Up regulation of HLA class I antigen expression and antigen specific CTL response in cervical cancer cells by the demethylating agent hydralazine and the histone deacetylase inhibitor valproic acid
... up-regulated HLA class-I expression and antigen- specific CTL response in cervical cancer cells following the use of hydralazine and valproic ...complex, class-I-related, a pow- ...
14
HLA class I and II genotype of the NCI 60 cell lines
... of HLA-epitope complexes is nar- rowly restricted to unique combinations [36], this infor- mation is critical to select reasonable candidates for antigen-discovery choosing cell lines bearing HLA ...
8
New HLA class I epitopes defined by murine monoclonal antibodies
... leukocyte antigen (HLA) antibodies infrequently react against one single HLA antigen because the epitopes they target are normally shared by more than one ...single antigen (SA) beads ...
6