The interferon regulatory factor pathway
Epstein-Barr Virus BGLF4 Kinase Suppresses the Interferon Regulatory Factor 3 Signaling Pathway
... 75. Zhou, Z. X., J. A. Kemppainen, and E. M. Wilson. 1995. Identification of three proline-directed phosphorylation sites in the human androgen recep- tor. Mol. Endocrinol. 9:605–615. 76. Zhu, F. X., S. M. King, E. J. ...
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway
... The ISG15 protein is covalently conjugated to target proteins upon activation of the interferon response. Interaction between vIRF1 and HERC5 was confirmed by immunoprecipitation, and the region between amino ...
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Control of Herpes Simplex Virus Replication Is Mediated through an Interferon Regulatory Factor 3-Dependent Pathway
... role for IRF-3-mediated pathways in controlling HSV-1 repli- cation in BMDCs and BMM, the focus was shifted to differ- entiating between two non-mutually exclusive mechanisms by which IRF-3 could be controlling HSV-1 ...
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Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway
... Interferon regulatory factor 3 (IRF3) is a 53 kDa tran- scription factor crucial in the non-MyD88, TRIF path- way of TLR signaling following activation of the TLR3 or TLR4 ...
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Interferon Regulatory Factor 6 Regulates Macrophage Polarization
... IRF-dependent pathway is one of main downstream signaling pathways triggered by the activation of TLRs, exerting essential transcriptional control on gene ...
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Inhibition of the ATM/p53 Signal Transduction Pathway by Kaposi's Sarcoma-Associated Herpesvirus Interferon Regulatory Factor 1
... p53-mediated signal transduction as a host surveillance. As seen with HIV-1 and HSV, KSHV replication likely induces a ATM/p53-mediated DNA damage response pathway. To block this host growth scrutiny and ...
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Feline Herpesvirus 1 US3 Blocks the Type I Interferon Signal Pathway by Targeting Interferon Regulatory Factor 3 Dimerization in a Kinase-Independent Manner
... IFN pathway and identified the Ser/Thr kinase US3 as the most powerful ...IFN pathway in a kinase-independent manner and via binding to the IRF3 IAD and preventing IRF3 ...
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Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target
... 2005 Interferon production and apoptosis in virus-infected cells are necessary to prevent progeny virus produc- tion and to eliminate infected ...through interferon regulatory factor 3 ...
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Virus-Activated Interferon Regulatory Factor 7 Upregulates Expression of the Interferon-Regulated BST2 Gene Independently of Interferon Signaling
... an interferon (IFN)-inducible host restriction factor that inhibits the release of many enveloped viruses and functions as a negative-feedback regulator of IFN production by plasmacytoid dendritic ...a ...
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The Host Response to West Nile Virus Infection Limits Viral Spread through the Activation of the Interferon Regulatory Factor 3 Pathway
... beta interferon (IFN-  ) and several IFN-stimulated genes late in infection of cultured human ...transcription factor IFN regulatory factor 3 ...IRF-3 pathway on WNV replication was ...
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 Targets MDM2 To Deregulate the p53 Tumor Suppressor Pathway
... utilize interferon (IFN)-mediated and p53-mediated irreversible cell cycle arrest and apoptosis as part of the overall host surveillance mechanism to ultimately block viral replication and ...key factor in ...
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Inhibition of DNA-Sensing Pathway by Marek's Disease Virus VP23 Protein through Suppression of Interferon Regulatory Factor 7 Activation
... IMPORTANCE Despite widespread vaccination, Marek’s disease (MD) continues to pose major challenges for the poultry industry worldwide. MDV causes immunosup- pression and deadly lymphomas in chickens, suggesting that this ...
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An Oligodeoxynucleotide with AAAG Repeats Significantly Attenuates Burn-induced Systemic inflammatory Responses by inhibiting interferon Regulatory Factor 5 Pathway
... necrosis factor-α (TNF-α) in the injured ...the interferon regulatory factor 5 (IRF5) binding site in the cis-regulatory elements of proinflammatory cytokines, we tried to explore ...
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Rhesus Cytomegalovirus Particles Prevent Activation of Interferon Regulatory Factor 3
... However, many of the endpoint genes induced in the IFN pathway are clearly detrimental to viral replication since they interfere with general protein translation or transport (20). Furthermore, IFN-induced or ...
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Arenavirus Nucleoprotein Targets Interferon Regulatory Factor-Activating Kinase IKKε
... subsequent nuclear translocation of the transcription factor (17). Considering the proposed role of the RIG-I/MDA5/MAVS path- way in innate detection of arenaviruses (14, 27, 28, 56), we probed the interaction of ...
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Inhibition of Interferon Regulatory Factor 3 Activation by Paramyxovirus V Protein
... apparent stickiness of the V protein may be due to overexpression of proteins. Among the molecules identified, IRF3 was further investigated in the present study, since IRF3 is located at the most downstream site in the ...
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Regulation of Hepatitis C Virus Replication by Interferon Regulatory Factor 1
... of interferon-stimulated genes, triggered by viral genomes, their transcripts and replicative ...investigated regulatory factors of the interferon-mediated antiviral system in cells expressing an HCV ...
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Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
... survival mechanisms deserves additional study. Our in vitro data demonstrate IRF1 as a dual regulator of autophagy and apoptosis in gliomal cell lines with bevacizumab treatment. This phenomenon is also observed in ...
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Human Rhinovirus Attenuates the Type I Interferon Response by Disrupting Activation of Interferon Regulatory Factor 3
... We found that, although RV14 infection results in altered levels of a wide variety of host mRNAs, induction of IFN-  mRNA or activation of the Jak/STAT pathway is not seen. Prior work has shown, and our results ...
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Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes
... The response of cells to virus infection includes activation of IRF-3, which cooperates with other transcriptional activators to induce IFN-␣/ genes via the ISRE enhancer (18, 26, 45). Secretion of newly synthesized ...
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