The L-type calcium channel
Antiepileptic Drug Induced Apoptosis Was Prevented by L Type Calcium Channel Activator in Cultured Rat Cortical Cells
... Figure 5. AED decreased and L-type calcium channel activator increased intracellular calcium levels. The fluorescence intensity values obtained from 100 cells in a fixed area of each ...
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Sleep deprivation of rats increases postsurgical expression and activity of L-type calcium channel in the dorsal root ganglion and slows recovery from postsurgical pain
... of L-type channels in DRG to verify that recovery from postsurgical pain is delayed upregulation and activation of these ...of L-type chan- nels leads to ...of L-type channels ...
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The L type calcium channel in the heart: the beat goes on
... Patients suffering from coronary disease may die of either heart failure or arrhythmias. Likewise, arrhythmias ascribable to dis- orders of conduction are also treated with CCBs that function, presumably, by inhibiting ...
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The L type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model
... -release channel and its associated membrane proteins and in an increase in ryanodine receptor ...the L-type Ca 2+ channel inhibitor diltiazem restores normal levels of these sarcoplasmic ...
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<p>Anticancer Effects of Antihypertensive L-Type Calcium Channel Blockers on Chemoresistant Lung Cancer Cells via Autophagy and Apoptosis</p>
... Autophagy is a cellular process responsible for deliver- ing proteins or organelles to lysosomes. 26 It not only helps maintain cellular homeostasis but also promotes survival during cellular stress situations. In ...
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T/L-type calcium channel blocker reduces the composite ranking of relative risk according to new KDIGO guidelines in patients with chronic kidney disease
... II type- 1 receptor blockers (ARBs) are respectively considered the most effective pharmacological approaches for renoprotection, reducing proteinuria more effectively than other antihypertensive drugs ...
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Ionic selectivity in L-type calcium channels by electrostatics and hard-core repulsion
... A physical model of selective “ion binding” in the L-type calcium channel is constructed, and consequences of the model are compared with experimental data. This reduced model treats only ions ...
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Energetics of calcium selectivity in a calcium channel: the ryanodine receptor case study
... concentration is increased. In this AMFE, current is reduced by 70% CHECK THIS which is significant, but not as dramatic as the 93% reduction found in the L-type calcium channel (21). The ...
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Energetics of calcium selectivity in a calcium channel: the ryanodine receptor case study
... real calcium channel that reproduces—and predicts—the experimental data over a wide range of ionic conditions and mutations is ...the L-type calcium channel ...
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Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes
... of calcium channels through their expression has been demonstrated in various cell ...specific channel isoform, systematically linked to a given pathology, is suggestive of a role for this channel in ...
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The L-type voltage-gated calcium channel modulates microglial pro-inflammatory activity
... the L-type voltage-gated calcium channel (VGCC) in a rat model of N-methyl-D-Aspartate-induced hippocampal ...the L-type ...functional L-type VGCC, and investigated ...
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Conditional Knockout of the L-Type Voltage-gated Calcium Channel CaV1.3 via the FLEX Switch
... Summary L-type voltage-gated calcium channels (VGCCs) play a central role in regulating intracellular calcium (Ca 2+ ) concentrations, thereby contributing to signal transduction in many ...
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Regulation of Myometrial Contractility: Defining the Contribution of the MaxiK Potassium Channel and the L- and T-type Calcium Channels
... region, and the region immediately upstream of exon 1b was shown to have promoter activity suggesting that these exon 1b containing transcripts are regulated by a separate promoter (Saada, Dai et al. 2003). This putative ...
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The intracellular loop between domains I and II of the B type calcium channel confers aspects of G protein sensitivity to the E type calcium channel
... chimeric calcium channel one key characteristic of G-protein modulation, that of slowed activation and reversal of this slowing by depolarizing ...the channel at depolarized potentials (Boland and ...
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Analytical models of calcium binding in a calcium channel
... The energy and concentration profiles are outputs of both al- gebraic Fermi and Poisson-Fermi differential equations. They are shown in Sec. II C including the effects of a 10 6 -fold variation of the Ca 2+ bath ...
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Analytical Models of Calcium Binding in a Calcium Channel
... This paper is organized with an introduction to the all-spheres model and a general discussion of the Fermi approach to ions and water in solutions and channels in Section 2. The anomalous mole fraction effect and the ...
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Demonstration of Binding of Neuronal Calcium Sensor-1 to the Ca(v)2.1 P/Q-Type Calcium Channel
... CaM is expressed in all neurons and one possibility is that specific neuronal populations that also express NCS-1 are able to utilise this Ca 2+ -sensor as an additional modulator of P/Q activity. NCS-1 has a higher Ca ...
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Deltamethrin Inhibits the Human T-type Voltage-Sensitive Calcium Channel (Cav3.2)
... The goal of this study was to determine the effect of deltamethrin, a pyrethroid insecticide, on Ca V 3.2, a human T-type voltage-sensitive calcium channel expressed in Xenopus laevis (X. laevis) ...
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Characterization of the molecular and electrophysiological properties of the T type calcium channel in human myometrium
... expressing cells (mean± SE (n=4 per point)) current density vs step voltage from a 35. holding potential of -50mV in the absence (closed circle) and presence (closed 36[r] ...
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Expression of calcium channel transcripts in the zebrafish heart: dominance of T type channels
... 2+ channel types and concentration-dependent I CaT inactivation by Ni 2+ were compared using one-way ANOVA followed by Tukey ’ s post hoc ...2+ channel genes and T- and L-type Ca 2+ current ...
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