The Notch signalling pathway
An investigation into how the cell cycle and the Notch signalling pathway regulate pronephrogenesis in Xenopus laevis
... ICD mRNA (Fig 4.15F), therefore Cyclin A2 acts downstream of the Notch signalling pathway in primary neurogenesis, that is after specification of the primary neuron precursors. These results, ...
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A role of Sirt1 in the Notch signalling pathway
... doi:10.1016/0092-8674(91)90064-6 Rebeiz, M., Miller, S.W., Posakony, J.W., Adams, M.D., Celniker, S.E., Holt, R.A., Evans, C.A., Gocayne, J.D., Amanatides, P.G., Scherer, S.E., Li, P.W., Hoskins, R.A., Galle, R.F., ...
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Characterization of NOTCH signalling pathway in PTEN-deficient prostate tumorigenesis
... of Notch signalling were associated with upregulation of a p27- mediated cellular senescence response in both Pten pc-/- and Pten pc-/- ; Trp53 pc-/- ...known NOTCH target gene and it is a regulator ...
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Exploring the role of the Notch signalling pathway in normal and malignant human haematopoiesis
... with Notch signalling A collaboration with Professor Andrea Brancale at the School of Pharmacy of Cardiff University was setup, aiming to obtain candidate small molecule agonists of Notch ...
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The effects of inhibiting the notch signalling pathway in triple negative breast cancer cell lines
... effect Notch inhibition has on the F-actin ...activates Notch signal induced migration (Chen et ...that Notch inhibition of MDA-MB-231 cells by DAPT and R04929097 GSIs increases E-cadherin expression ...
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Diverse requirements for Notch signalling in mammals
... the Notch signalling pathway in the process of somitogenesis, and the fact that the components of this system are very well characterised, these genes are a useful starting point to investigate the ...
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The role of Notch signalling in ovarian angiogenesis
... of Notch signalling pathway elements in the ovary and key roles for regulatory Notch signal- ling pathways on angiogenesis in pathological ...ovary. Notch signalling ...
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Notch signalling mediates reproductive constraint in the worker honeybee
... of Notch signalling can overcome the repressive effect of queen pheromone and promote ovary activity in adult worker ...that Notch signalling acts on the earliest stages of oogenesis and that ...
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Co-regulation of Gremlin and Notch signalling in diabetic nephropathy
... indeed Notch family signalling may play a more significant role in tubulointerstitial fibrosis than in glomerulo- sclerosis during ...of Notch family genes such as Jagged1 and Hes1 in the kidneys of ...
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Notch pathway: a bistable inducer of biological noise?
... the Notch pathway adapts to various phases of cell cycle with peak signalling detected at M/early G1 phase ...to Notch, the downstream targets, ...the Notch signalling ...
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Notch signalling is required for both dauer maintenance and recovery in C elegans
... the Notch signalling pathway during dauer ...insulin-like signalling functions in parallel or downstream of the lin-12 Notch ...
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The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate Notch signalling
... increased Notch signalling such as the expression of Notch target genes were demonstrated in a human CYLD defective model, as suggested by the luciferase ...98 Notch related transcripts, ...
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"Notch Off": a perspective on the termination of Notch signalling
... regulate Notch signalling have been described, involving processes like transcriptional up-regulation of DSL ligands, their selective recy- cling to the cell membrane, and post-translational modifications ...
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Notch Signalling as a Therapeutic Target in Cancer
... cancer Notch plays a crucial role in mammary development and, as a result, abnormalities in the pathway lead to mammary ...between Notch and breast cancer came with the finding that the Notch4 locus ...
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Nonlinear Dynamics of Notch -Delta Signalling
... The Notch signaling pathway is a highly conserved ell signaling system present in most multicellular ...different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and ...The Notch ...
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Is there a role for Notch signalling in human breast cancer?
... unregulated Notch signalling has also been pro- posed in cervical cancer, largely because intense cyto- plasmic and nuclear staining of Notch1 and Notch2 proteins has been observed in a majority of early ...
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Sequential combination of cisplatin with eugenol targets ovarian cancer stem cells through the Notch-Hes1 signalling pathway
... the Notch signal- ling [7]. The alteration of the Notch pathway genes has been reported in approximately 22% of all analyzed ovar- ian tumors ...The Notch path- way is primarily initiated by ...
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Wnt/Notch signalling and information processing during development
... Beyond signalling: a function for Wnt The lack of a detailed mechanism for Wnt signalling should not deter us from tackling aspects of its ...-catenin signalling offers two striking ...this ...
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A novel reporter of notch signalling indicates regulated and random notch activation during vertebrate neurogenesis
... how Notch activity correlates with cell cycle phases of individual cell lineages in the developing chick spinal ...that Notch activity can be triggered between 1 to 27 h before cell division, or 4 to 12 h ...
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Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling
... The Notch pathway is a complex and fundamental mechanism in em- bryonic development and ...Although Notch signalling is required for vascular development, 11 including lymphatic development, ...
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