The Promoter
Single nucleotide polymorphism 1623 A/G (rs180195) in the promoter of the Thyroglobulin gene is associated with autoimmune thyroid disease but not with thyroid ophthalmopathy
... in the promoter region of the TG gene modified a binding site for IRF-1, a major interferon-induced transcription fac- tor. The same group showed that the polymorphism 1623 A/G SNP (rs180195) increased ...
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Using the promoters of MerR family proteins as “rheostats” to engineer whole-cell heavy metal biosensors with adjustable sensitivity
... file 2: Table S3), and they were constructed into the plasmid pMetalRFP. The relative RFP fluorescence of P429–1 was 0.0818 with its log values of promoter expression efficiency at 3.413, which was the closest to ...
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Transcriptional Regulation of BK Virus by Nuclear Factor of Activated T Cells
... BKV promoter is sensitive to changes in the relative levels of activators and that different combinations of these factors can both negatively and positively influence BKV transcription and ...the promoter ...
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Temporal and Spatial Control of HGC1 Expression Results in Hgc1 Localization to the Apical Cells of Hyphae in Candida albicans
... Transcription is detected only in the apical cells of hyphae. The promoter swap experiment suggested that transcription from the HGC1 promoter was primarily in the apical cell. To validate this observation, ...
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Proto-oncogenic miR-744 is upregulated by transcription factor c-Jun via a promoter activation mechanism
... the promoter of its host gene ...own promoter positioned immediately upstream of miRNAs ...potential promoter like sequence located within 500 bp upstream of miR-744 gene, which implied the existence ...
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<p>The Association Between Interleukin 1 Beta Promoter Polymorphisms And Keratoconus Incidence And Severity In An Egyptian Population</p>
... the promoter poly- morphism can result in IL1-B protein overexpression, leading to increased apoptotic activity in corneal tissue documented in keratoconus ...
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Gene promoter hypermethylation in leukoplakia of the oral mucosa
... the promoter region might occur earlier in tumorigenesis, particularly in premalignant lesions, we examined biopsies from 111 participants in a chemoprevention trial aimed at reversal of oral leukoplakia, using ...
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Wide-dynamic-range promoters engineered for cyanobacteria
... the promoter-RNAP complex after formation of the close complex [21] through a non-optimal contact with the region ...improved promoter strength in the engineered L promoters other than the L12 ...
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Tumour-specific arginine vasopressin promoter activation in small-cell lung cancer
... AVP promoter region has been sequenced (Bahnsen et al, ...proximal promoter region have been identified, for example those mediating cAMP responsiveness (Verbeeck et al, 1991; Pardy et al, ...human ...
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Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter
... full-length promoter was activated both by Brn-3a and, to a greater extent, by p53 with the two factors together producing an enhanced level of activation compared to either factor alone in accordance with our ...
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Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria
... NF-κB promoter activity and that the effect was evident only when the wild type promoter was used and less pronounced when the promoter was mutated for the NF-κB binding site, it has been ...
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Transcriptional Regulation of the Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor Gene
... The promoter region of the minor transcript, which was mainly expressed in uninduced BCBL-1 cells, did not contain a canonical TATA box, but a cap-like element and an initiator element flanked the transcription ...
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Delivery of a survivin promoter-driven antisense survivin-expressing plasmid DNA as a cancer therapeutic: a proof-of-concept study
... survivin promoter followed up with a luciferase reporter gene and is used for the subse- quent construction of the survivin promoter-driven antisense survivin (pSur/AS-Sur)-expressing plasmid DNA, can be ...
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Aberrant Methylation of Ribonucleotide Reductase Subunit M2 Is Closely Associated with Oral Cancer
... methylation plays a significant role [13_C14]. In the Methylation-Specific Polymerase Chain Reaction genomes of mammals, methylation takes place at CpG (MSPCR): The procedure was conducted according to islands that are ...
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Cloning and Promoter Identification of Acetoacetyl-CoA Thiolase Gene from Oil Palm, Elaeis guineensis Jacq.
... vector. A clone was successfully isolated in this study using labeled cDNA clone of the putative acetoacetyl-CoA thiolase. A clone, designated as λOP1 was sequenced and analyzed. The λOP1 fragment is 12,470 bp in length ...
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Regulation of expression of the rat CYP2B1 and CYP2B2 genes
... 1993, Roman, et al., 1993). The rat CYP4A1 and rabbit CYP4A6 are the most highly induced in the liver (Johnson, at a!., 1996). A member of the nuclear receptor superfamily known as peroxisome proliferator activator ...
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Competitive binding of viral E2 protein and mammalian core-binding factor to transcriptional control sequences of human papillomavirus type 8 and bovine papillomavirus type 1.
... 1 are negatively regulated by viral E2 proteins via the promoter proximal binding sites P2 and BS1, respec- tively. Mutations of these E2 binding sites can reduce basal promoter activity. This suggests ...
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Core promoter acetylation is not required for high transcription from the phosphoenolpyruvate carboxylase promoter in maize
... the promoter of the clock component TOC1 is regulated by acetylation/deacetylation cycles that are controlled by the endogenous clock itself ...upstream promoter at position -1186, but not in the core ...
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Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein.
... immediate-early promoter/enhancer (4) directing expression of HPV18 E2 and the weaker SV40 early promoter in the case of BPV1 ...early promoter, which directs the expression of the BPV1 E2 protein, ...
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A novel viral RNA species in Sindbis virus-infected cells.
... the promoter that were engaged in transcriptional ...the promoter because initiation complexes at the promoter would physically block continued genomic RNA ...the promoter but then dissociate ...
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