Thymidine Kinase Gene
A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.
... Nucleotide sequence of the herpes simplex virus type 2 HSV-2 thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide and its comparison with the HSV-1 thy[r] ...
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Nucleotide sequence of the herpes simplex virus type 2 thymidine kinase gene.
... GALLOWAY* Fred Hutchinson Cancer Research Center, Seattle, Washington 98104 We have determined the complete nucleotide sequence of the thymidine kinase gene of herpes simplex virus HSV t[r] ...
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Identification of the thymidine kinase gene of feline herpesvirus: use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs.
... Nucleotide sequence of the herpes simplex virus type 2 HSV-2 thymidine kinase gene and predicted amino acid sequence of the thymidine kinase polypeptide and its comparison with the HSV-1[r] ...
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Genetic and biochemical characterization of the thymidine kinase gene from herpesvirus of turkeys.
... A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.. Induction of both thymidine and deoxycytidine [r] ...
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Encapsidation and expression of the herpes thymidine kinase gene in polyoma virus.
... At the indicated times, 5 ml of viral supernatant extracts were prepared, and 0.1 ml was assayed for A the ability to produce at 38°C viral T-antigen by extracts of PY60TK- plus TS25B-co[r] ...
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Control of expression of the vaccinia virus thymidine kinase gene.
... ANDREW BALL Biophysics Laboratory, Graduate School, and Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706 m[r] ...
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Expression and characterization of the thymidine kinase gene of African swine fever virus.
... 1046 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The thymidine kinase TK gene of African swine fever virus ASFV was located within the viral genome by using two deg[r] ...
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Random mutagenesis of the thymidine kinase gene of varicella-zoster virus.
... Nucleotide and predicted amino acid sequences of the Marek's disease virus and turkey herpesvirus thymidine kinase genes; comparison with thymidine kinase genes of other herpesviruses.. [r] ...
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Identification and nucleotide sequence of the thymidine kinase gene of Shope fibroma virus.
... Homology analysis of the deduced SFV TK gene protein sequence indicates a close relationship with the vaccinia, variola, and monkeypox orthopoxvirus TK genes and the human, mouse, hamste[r] ...
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Splicing-Independent Expression of the Herpes Simplex Virus Type 1 Thymidine Kinase Gene Is Mediated by Three cis-Acting RNA Subelements
... TK gene, the HBV PRE, and the ...TK gene sequences. The TK gene induces CAT expression to levels comparable to those induced by the HBV ...TK gene sequences to induce cytoplasmic localization ...
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Mapping and identification of the vaccinia virus thymidine kinase gene.
... This DNA fragment encodes four known early polypeptides, and to determine which of these was thymidine kinase, early VV mRNA was fractionated by sucrose gradient centrifugation and used [r] ...
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Properties of Cells Carrying the Herpes Simplex Virus Type 2 Thymidine Kinase Gene: Mechanisms of Reversion to a Thymidine Kinase-Negative Phenotype
... However we cannot exclude the possibility that Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest cleic acid hybridizations studies have shown that class 3 revertants reta[r] ...
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Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product.
... Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of Herpes simplex virus type 1.. Predicted n[r] ...
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Selective assay for herpes simplex viruses expressing thymidine kinase.
... Introduction of herpes simplex virus thymidine kinase gene into mouse cells using virus DNA or transformed cell DNA.. Transfer of thymidine kinase to thymidine kinaseless L cells by infe[r] ...
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Characterization of the regulatory functions of varicella-zoster virus open reading frame 4 gene product.
... When various amounts of ORF4 were transfected in the presence of early gene promoters, dose-dependent transactivation was evidenced with the thymidine kinase gene ORF36 and the major DNA[r] ...
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The unique sequence of the herpes simplex virus 1 L component contains an additional translated open reading frame designated UL49.5.
... This gene, consisting of the authentic promoter and chimeric coding domain, was inserted into the thymidine kinase gene of wild-type virus and in infected cells expressed a protein which[r] ...
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Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2.
... These results suggest that a strain of herpes simplex virus type 2 containing a deletion of the thymidine kinase gene will be useful in studying the cellular basis of mucosal immunity in[r] ...
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In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs
... of thymidine kinase (TK)-deficient or TK-altered virus, although a few cases were doc- umented with an alteration in DNA polymerase (Pol) ...thymidylate kinase activity, which converts dTMP to ...
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Human Herpesvirus 8-Encoded Thymidine Kinase and Phosphotransferase Homologues Confer Sensitivity to Ganciclovir
... herpesvirus kinase gene families have been identified that activate these ...(HSV) thymidine kinase (TK) and HCMV UL97 are prototypes of the TK and phosphotransfer- ase (PT) gene ...
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Extended disease-free interval of 6 years in a recurrent glioblastoma multiforme patient treated with G207 oncolytic viral therapy
... cally engineered HSV with two independent mutations to minimize the risk of wild-type reversion or recombination. Since G207 is a temperate sensitive virus, any development of encephalitis with resultant increase of body ...
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