Thymidine phosphorylase
The cytosol activity of thymidine phosphorylase in endometrial cancer
... Thymidine phosphorylase (TP: EC 2.4.2.4.) catalyses the reversible phosphorolysis of thymidine to thymine and 2- deoxyribose-1-phosphate [1]. TP is identical with platelet- derived endothelial cell ...
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Original Article Correlations between expression levels of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase, and efficacy of 5-fluorouracil-based chemotherapy for advanced colorectal cancer
... Abstract: The efficacy of 5-fluorouracil (5-FU)-based chemotherapy for colorectal cancer (CRC) widely varies among patients; therefore, it is difficult to accurately predict chemotherapeutic responses. Some recent ...
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The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast like synoviocytes
... Figure 1 Effects of mithramycin on gliostatin/thymidine phosphorylase (GLS/TP) promoter activity based on deletion constructs. Closed ovals indicate Sp1-binding sites. Open ovals indicate ...
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Site specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency
... Mitochondrial neurogastrointestinal encephalomy- opathy (MNGIE) is characterized clinically by onset in the second to fifth decade of life, ptosis, progressive external ophthalmoparesis, gastrointestinal dysmo- tility, ...
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Systemic immune-inflammation index, thymidine phosphorylase and survival of localized gastric cancer patients after curative
... unclear. Thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, has a role in tumorigenesis, angiogenesis, increasing cancer cell invasion activity and promoting ...
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Original Article Thymidine phosphorylase and hypoxia-inducible factor 1-α expression in clinical stage II/III rectal cancer: association with response to neoadjuvant chemoradiation therapy and prognosis
... of thymidine phosphorylase (TP), and hypoxia-inducible factor alpha (HIF-1α) could predict pathologic response to neoadjuvant chemoradiation therapy with oxaliplatin and capecitabine (XELOXART) and outcomes ...
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Clinical significance of the thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase mRNA expressions in hepatocellular carcinoma patients receiving 5-fluorouracil-based transarterial chemoembolization treatment
... Purpose: To determine whether 5-fluorouracil (5-FU) sensitivity is associated with the mRNA expressions of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and[r] ...
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Pilot study investigating the prognostic significance of thymidine phosphorylase expression in patients with metastatic breast cancer: a single institution retrospective analysis
... Abbreviations: Bc, breast cancer; Dcis, ductal carcinoma in situ; er, estrogen receptor; Pr, progesterone receptor; ilc, invasive lobular carcinoma; iDc, invasive ductal carcinoma; TTP[r] ...
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Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma
... In light of previous studies showing TAMs to be the only major source of TNF-a in breast carcinoma Miles et al, 1994; Pusztai et al, 1994; Lewis and McGee, 1996, we have interpreted our [r] ...
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4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression
... Real-time quantitative polymerase chain reaction (qPCR) Expression levels of HAS2, HAS3, CD44, vascular endo- thelial growth factor (VEGF), and thymidine phosphoryl- ase (TP) were determined in HRA cells cultured ...
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Gastrointestinal Dysmotility in MNGIE: from thymidine phosphorylase enzyme deficiency to altered interstitial cells of Cajal
... altered thymidine (dThd) and deoxyuridine (dUrd) levels that leads to (1) mitochondrial DNA (mtDNA) instability, mitochondrial energy failure, interference with mitochondrial-mediated Ca 2+ cycling [61] and cells ...
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Further investigation into the roles of vascular endothelial growth factor and thymidine phosphorylase in urological malignancy
... Relation of vascular endothelial growth factor production to expression and regulation of hypoxia inducible factor-la and hypoxia inducible factor-2a in human bladder [r] ...
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Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn’s disease
... residual thymidine phosphorylase ...plasma thymidine levels in suspected Crohn ’ s disease to rule out MNGIE, particularly if white matter abnormalities are identified on ...
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MOLECULAR MARKERS FOR CAPECITABINE THERAPY: A REVIEW
... Thymidine phosphorylase (TP), also known as platelet-derived endothelial cell growth factor (PD- ECGF), is an enzyme expressed in many normal tissues and cells with a key role in pyrimidine salvage pathway ...
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Early events after infection of Escherichia coli by bacteriophage T5. Induction of a 5'-nucleotidase activity and excretion of free bases.
... Since the specific activity of dTMP nucleotidase in infected cells was only 60 nmol per min per mg at its maximal level, the host thymidine phosphorylase activity was about twice that of[r] ...
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Search | Preprints
... 25. Yano, S.; Kazuno, H.; Sato, T.; Suzuki, N.; Emura, T.; Wierzba, K.; Yamashita, J.I.; Tada, Y.; Yamada, Y.; Fukushima, M.; Asao, T. Synthesis and evaluation of 6-methylene- bridged uracil derivatives. Part 2: ...
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Angiogenic biomarkers in children with congenital heart disease: possible implications
... Angiogenic growth factors are so called because of their varying ability to induce the proliferation of various cells in vitro, which contribute to the process of angio- genesis in vivo [5]. Vascular endothelial growth ...
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Thymidine Catabolism by Normal and Leukemic Human Leukocytes
... When the supernatant solution from incubation of TABLE VI CML or normal leukocytes in phosphate buffer or the homogenate from the residual cells was Relation of thymidine phosphorylase a[r] ...
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OPRT Is a Potential Predictive Factor for the Response to S 1 in Gastric Cancer
... midine phosphorylase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase using quantitative re- verse-transcriptase polymerase chain ...synthase, thymidine phosphorylase and ...
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Induction of thymidine kinase and DNase in varicella-zoster virus-infected cells and kinetic properties of the virus-induced thymidine kinase.
... 1 Induction of Thymidine Kinase and DNase in Varicella-Zoster Virus-Infected Cells and Kinetic Properties of the VirusInduced Thymidine Kinase Received for publication 23 January 1979 Th[r] ...
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