TLR4 signaling
Lipopolysaccharide and palmitic acid synergistically induced MCP-1 production via MAPK-meditated TLR4 signaling pathway in RAW264.7 cells
... Diabetes incidence increases in people with obesity characterized as higher content of saturated fatty acid (FA). Data from type II diabetes patients with obesity shows that FA is correlated to chronic low-grade inflam- ...
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Respiratory Syncytial Virus Fusion Protein Induced Toll Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and Requires Direct Interaction with MD 2
... the TLR4- mediated inflammatory response. LPS, the prototype TLR4 ago- nist, is among the most potent of inflammatory stimuli in vivo and in vitro and is ...a TLR4- mediated proinflammatory response, ...
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MD-2 is required for disulfide HMGB1-dependent TLR4 signaling
... the TLR4 signalosome distinguished between HMGB1 ...extracellular TLR4 adaptor, myeloid differentiation factor 2 (MD-2), binds specifically to the cytokine-inducing disulfide isoform of HMGB1, to the ...
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Contribution of TLR4 signaling in intermittent hypoxia mediated atherosclerosis progression
... AS. TLR4 signaling in AS is implicated in activation of inflammation and lipid accumulation [15], which are all associated with plaque progression and ...that TLR4 sign- aling may be involved in the ...
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Original Article Glycine protects against non-alcoholic hepatitis by downregulation of the TLR4 signaling pathway
... important TLR4 ligand, may play a role in meta- bolic diseases induced by high-sugar/high-fat diets ...study, TLR4 and TNFα levels in NASH rat liver were increased ...and TLR4 in the absence of ...
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Original Article TLR4 signaling is activated in ventilator-induced diaphragm dysfunction in rats
... that TLR4 plays important role in early inflammation of acute lung injury and thus is involved in acute lung injury occurrence and development [3, ...of TLR4 in ventilator-associated diaphragmatic ...of ...
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Hepatic TLR4 signaling is activated by LPS from digestive tract during SARA, and epigenetic mechanisms contribute to enforced TLR4 expression
... enforced TLR4 signaling because SARA increased the concentrations of TLR4 mRNA and protein in the liver and the abundance of both the NF-kB-p65 factor and its active phosphorylated ...enhanced ...
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The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling
... Abstract: Signaling by two of the most important bacteria-sensing TLRs, TLR2 and TLR4, involves two adaptor proteins, MyD88 adaptor-like (Mal) and Toll/IL-1 receptor (TIR) domain-containing adaptor-inducing ...
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Corilagin ameliorates the extreme inflammatory status in sepsis through TLR4 signaling pathways
... Trizol reagent, RNAios and Real-time PCR kit were ob- tained from TaKaRa Company (Dalian, China). Anti- MyD88, anti-TRAF6, anti-TRIF and anti-TLR4 antibodies were offered from Abcam Biotechnology (MA, USA). LPS ...
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Quercetin Decreases Th17 Production by Down-Regulation of MAPK- TLR4 Signaling Pathway on T Cells in Dental Pulpitis
... T cells isolated from the pulpitis and normal tissues were cultured at 1×10 6 cell/ml in RPMI-1640 medium (GIBCO; Invitrogen corporation, UK) supplemented with 20% fetal bovine serum, and 1% streptomycin or peni- cillin. ...
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Original Article Lipopolysaccharide activated TLR4/NF-κB signaling pathway of fibroblasts from uterine fibroids
... that TLR4/NF-κB signaling may be cross- talk with the mechanism of LPS-induced fibro- blast activation, which need further exploration in ...the TLR4/ NF-κB ...a TLR4 signaling ...
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Accelerated Prion Disease Pathogenesis in Toll-Like Receptor 4 Signaling-Mutant Mice
... in TLR4-mutant C3H/HeJ mice can be ...between TLR4 signaling and protective host responses to scrapie infection may be provided in the fact that TLR4 signaling induces anti-inflammatory ...
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The TLR4-TRIF Pathway Protects against H5N1 Influenza Virus Infection
... of TLR4. To ascertain whether the TLR4 signaling pathway was required for LPS-mediated pro- tection against influenza virus-induced lethality, we next exam- ined the replication kinetics of a highly ...
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Emerging role of Toll-like receptor 4 in hepatocellular carcinoma
... Functional TLR4 expression has been linked to HCC development. TLR4 may serve an important role in HCC cancer tumorigenesis by promoting the malignant transformation of epithelial cells and tumor ...complex ...
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Lipid induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
... enhance TLR4 signal- ing has been controversial and ...activate TLR4, and many groups have report- ed that SFAs, but not unsaturated fatty acids, are TLR4 agonists ...activate TLR4 in HEK-293 ...
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Curcumin attenuates MSU crystal induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
... that TLR4 mediated the initial steps of gout pathogenesis and that TLR4 expression was pivotal to MSU crystal-induced inflammation ...of TLR4. In the TLR4 signaling pathway, ...
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LPS-induced TLR4 neuroinflammatory signaling in CHME-5 microglial cells
... (TLR4) signaling in CHME-5, a microglial cell line, is expected to be of value as an experimental model of inflammatory signaling in the central nervous system ...
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TLR4 links innate immunity and fatty acid–induced insulin resistance
... activate TLR4 signaling. (A) FFAs activate TLR4 signaling in transfected 293T cells (n = 6; *P < ...with TLR4/MD-2 expression vectors, with or without dominant nega- tive MyD88 ...
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Genomic adaptations to chemosymbiosis in the deep-sea seep-dwelling tubeworm Lamellibrachia luymesi
... Interestingly, we found the TAB1 gene (an important component of the TLR4 signaling pathway) is under positive selection (Additional file 1 : Table S6).. Although the physiological role [r] ...
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Original Article LPS induces activation of the TLR4 pathway in fibroblasts and promotes skin scar formation through collagen I and TGF-β in skin lesions
... activate TLR4 signaling, leading to the overexpression of collagen I and TGF-β and the induction of hypertrophic scar forma- ...the TLR4 signaling pathway in 3T3-L1 cells in vitro and ...
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