TNF-α receptor 1
The Latency-Associated UL138 Gene Product of Human Cytomegalovirus Sensitizes Cells to Tumor Necrosis Factor Alpha (TNF-α) Signaling by Upregulating TNF-α Receptor 1 Cell Surface Expression
... of TNF- ␣ , this underscores the significance of restraining TNF- ␣ signaling for a number of different viruses, including some herpesviruses (see ...to TNF- ␣ ...(39), TNF- ␣ has been shown ...
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Inhibiting TNF-α signaling does not attenuate induction of endotoxin tolerance
... exogenous TNF- α stimulation can induce the production of endogenous TNF- α and generate a tolerant-like state upon subsequent ...of TNF- α signaling and an autocrine ...
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The Cytomegaloviral Protein pUL138 Acts as Potentiator of Tumor Necrosis Factor (TNF) Receptor 1 Surface Density To Enhance ULb′-Encoded Modulation of TNF-α Signaling
... of TNF- ␣ signaling and NF- B activation appear to dominate or bypass the inhibitory ...of TNF- ␣ signaling. In fibroblast culture, the negative modulation of TNF responses might be more beneficial ...
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Original Article Tumor necrosis factor-α (TNF-α) and its receptor gene polymorphisms association with the susceptibility to papillary thyroid cancer in Chinese Han population
... the TNF-R1 ...that TNF-α ex- pressed by BM-derived cells (BMDCs) stimu- lates the TNFR1 on BMDCs by an autocuing or paracrine manner, which is important for gastric tumor promotion [41-43, ...
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TNF α is crucial for the development of autoimmune arthritis in IL 1 receptor antagonist–deficient mice
... IL-2 receptor α (CD25), CD69, CD44, CD40 ligand (CD40L; also known as CD154), and OX40 (also known as CD134) (12) CD40L on T cells and its receptor on APCs, as well as OX40 on T cells and its ligand ...
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Preventive Effect of SA13353, a Novel Transient Receptor Potential Vanilloid 1 Agonist, on Ischemia/Reperfusion Induced Renal Injury in Rats
... including TNF-α, have a critical role [30]. CINC-1, a major factor in acute inflammation, is responsible for the activation of neutrophils and for neutrophil chemotaxis to sites of injury ...of ...
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Human Cytomegalovirus Infection Inhibits Tumor Necrosis Factor Alpha (TNF-α) Signaling by Targeting the 55-Kilodalton TNF-α Receptor
... FIG. 6. Down-regulation of TNFRI by HCMV is due to receptor relocalization. (A) Uninfected control (CON) U373 cells (a and c) or U373 cells infected overnight with AD169 (5 PFU/cell) (b and d) were fixed and ...
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Genomic Profiling of Tumor Necrosis Factor Alpha (TNF-α) Receptor and Interleukin-1 Receptor Knockout Mice Reveals a Link between TNF-α Signaling and Increased Severity of 1918 Pandemic Influenza Virus Infection
... at 1, 3, and 5 ...A 1:2,000 dilution of a mouse-derived mono- clonal antibody (P13C11) specific for a type A influenza virus nucleoprotein was applied and allowed to incubate for 12 h at ...
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The Role of Death Domains Superfamily in Multiple Sclerosis Pathogenesis
... of TNF-α to TNF R1 results in trimerization and intracellular oligomerization of death domain; after the con- formational change, TNFR1 recruits an adaptor protein TRADD via its ...complex), ...
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TWEAK enhances TGF-β-induced epithelial-mesenchymal transition in human bronchial epithelial cells
... TWEAK receptor Fn14 ...this receptor existed on BEAS-2B cells (Additional file 1: Figure ...to TNF-α in BEAS-2B ...ng/ml), TNF-α (10 ng/ml), TWEAK (100 ng/ml), or TGF-β1 ...
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TNF-α and TNF-R-1 level in pregnancy with ecotopic pregnancy
... (TNF-α), receptor R1 to tumor necrotic factor alpha (R1-TNF-α)) were carried out using commercial test systems "Hema" (Czech Republic), "Human GmbH" (Wiefbaden, Germany) ...
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Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages
... and TNF-α, consequently resulting in phago- cytically inactive ...and TNF-α excessively induced upon Aβ1-42 exposure might explain why inflammatory macro- phages fail to effectively ...
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Original Article The correlative analysis of IL-1β, IL-6, TNF-α, Hcy, hs-CRP and interleukin 1 receptor antagonist in different types of dementia in patients with cognitive dysfunction
... IL-6, TNF-α, Hcy, hs-CRP and interleukin 1 receptor antagonist exhibited obvious differences in different types of dementia patients with cognitive ...IL-6, TNF-α, Hcy, hs-CRP ...
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TNF α downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding
... hormone receptor (GHR) gene ...that TNF- α suppresses GHR expression by inhibiting Sp1/Sp3 ...elements. TNF- α was integral to this response, as LPS did not affect hepatic Sp1/Sp3 ...
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Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria
... apoptosis. TNF-α exerts its action via cell-surface ...type 1 (TNF-R1, p55) and 2 (TNF-R1, p75), as well as soluble forms (sTNF-Rs), sTNF-R1 and sTNF-R2, ...to TNF-Rs, ...
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The tumor promoting actions of TNF α involve TNFR1 and IL 17 in ovarian cancer in mice and humans
... cytokine TNF-α is an important component of this interplay, but its effects are pleiotropic and therefore remain to be completely ...either TNF receptor 1 (TNFR1) signaling was ...
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Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels
... TNFR1 shedding determines lung microvascular E-selectin expression. (A) Upper images show live E-selectin immunofluorescence (red) in microvessels coloaded with cytosolic fluorescence of calcein (green). Lungs are from ...
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Neurotransmitter receptors on microglia
... Microglia, the dynamic, motile phagocytes of the central nervous system, were traditionally viewed as proin fl ammatory cells that promote neuronal toxicity and death. However, this view failed to account for the ...
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Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-α and dexamethasone
... To investigate the transcriptional regulation of CD38 expression in HASM cells, we cloned a putative 3 kb pro- moter fragment (GenBank Acc. No. DQ091293) from K562 cells into the pGL3 basic vector. The cd38 promoter ...
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Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice
... from circulating cytokines have been shown to be pre- vented by a blockade of SERT [68]. Furthermore, SERT mutant rats show abnormal behaviour (including de- creased sucrose preference, decreased spontaneous ac- tivity ...
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