tolerogenic dendritic cell
Tolerogenic Dendritic Cells Induced by BD750 Ameliorate Proinflammatory T cell Responses and Experimental Autoimmune Encephalitis in Mice
... induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune encephalitis (EAE) in ...T cell proliferation, Th1 and Th17 cell functional dif- ferentiation, and ...
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Generation, Characteristics and Clinical Trials of Ex Vivo Generated Tolerogenic Dendritic Cells
... co-inhibitory molecules, production of immunosuppressive cytokines and mediators, and/or induction of Tregs. Based on the successes in small animal models, several clinical trials have been completed or are on-going in ...
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In vitro suppression of immune responses using monocyte derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome
... Dendritic cells (DC) were generated from monocytes iso- lated from fresh blood collected into heparin tubes from pSS patients and healthy blood donors as described pre- viously [12]. The autologous peripheral ...
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Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells
... MSC expressed high levels of Notch-2, Jagged-1 and Delta like ligand-1 and lower levels of Notch-1 and Jagged-2 (Additional file 2: Figure S2). Previously pub- lished data on the Notch ligand Jagged-1 suggested a role ...
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Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA
... findings, as demonstrated by us and others [4, 5, 8], might point toward other antigen-specific mechanisms of toler- ance induction responsible for clinical benefit. For instance, it has been demonstrated that ...
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T cell killing by tolerogenic dendritic cells protects mice from allergy
... DCs comprise multiple subsets and exhibit crucial functions as activators and regulators of immune processes including tolerance induction (48, 49). Although the underlying mechanisms have not been fully elucidated, it ...
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Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL-10, thereby promoting Th2- and Tr1-biased T-cell immunity
... T cell responses and the establishment of either immunity or ...induce tolerogenic DCs and IL-10 production in our study (Supplementary Figure ...IL-10-producing tolerogenic DCs (Supplementary Figure ...
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Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients
... A crucial role of NKT cells in anti-microbial and anti- cancer response, as well as preventing autoimmune diseases such as MS, T1D, lupus or RA, has been reported [21, 22]. NKT cells constitute a minority population of T ...
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Comparative study of clinical grade human tolerogenic dendritic cells
... of tolerogenic potential for ‘’ negative cellular vaccines ’’ ...this tolerogenic product preserves this feature up to 5 days after remov- ing Dexa ...
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Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice
... observed. Tolerogenic dendritic cells present antigens to antigen- specific T cells, but fail to deliver adequate co-stimula- tory signals for effector T cell activation and proliferation ...
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Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells
... Dendritic cells are professional APCs and sentinels of the immune system that efficiently sample allergens in the airways leading to a cascade of events that culminates in the induction of Th2 type immune ...
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Dendritic cells, hapten presentation and lymph node cell activation following cutaneous sensitization in the mouse
... These findings, then, confirm the general proposal that T-cell activation requires two signals - the two signal hypothesis. Recognition of Ia-peptide complexes presented on macrophage (antigen presenting) ...
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Role of LFA-1 and ICAM-1 in Cancer
... Because there are studies describing alterations of LFA-1 signaling pathway in chronic lymphocytic leukemia (CLL), these studies are being considered here. CLL, the most common leukemia in the Western world, is ...
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A role for pre-mNK cells in tumor progression
... pre-mNK cell activation through NKG2D ligands on murine tumors, allowing them to present antigen once it is acquired ...T cell activity by expressing high levels of CD39/73 and CD38, using adenosine as a ...
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Schnorfeil, Frauke Marie (2011): MicroRNAs regulate Dendritic Cell Development and Function. Dissertation, LMU München: Medizinische Fakultät
... Binding of cytokines to their cognate cellular receptors results in downstream signaling and the activation of transcription factors. On the one hand, global DC development requires tran- scription factors that are ...
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Virus-Like Vesicle-Based Therapeutic Vaccine Vectors for Chronic Hepatitis B Virus Infection
... T cell pool to a particular ...T cell response of a magnitude similar to that of the primary response to VLV-MHBs ...T cell expansion associated with protection from hydrodynamic challenge at 6 weeks ...
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Influence of synthetic superparamagnetic iron oxide on dendritic cells
... mature dendritic cells were collected, washed with phosphate-buffered saline, and resuspended in 30% HCl (v/v) at 60 ° C for two ...SPIO-labeled dendritic cells was expressed as the amount of Fe 2 O 3 ...
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Dendritic Cell Autophagy Contributes to Herpes Simplex Virus Driven Stromal Keratitis and Immunopathology
... Consistent with previous reports (37–39, 47), we found that DC-autophagy has a significant impact on the development of adaptive immunity, specifically CD4 ⫹ T cell responses. DC- autophagy was also reported to ...
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Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus Induced Autoimmunity
... antigen-presenting cell (APC) function following TMEV infec- ...especially dendritic cells (DCs), are a critical bridge between the innate and adaptive immune responses and are the primary cells involved in ...
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Antigen processing and T cell priming by mouse dendritic cells
... Cibotti et al made H-2^ mice transgenic for Hen Eggwhite Lysozyme, which was ubiquitously expressed(Cibotti e ta l, 1992). The determinant-specificity of the T cell repertoire for HEL in these mice was then ...
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