Toll-Like Receptor Signalling
Toll and Toll like receptor signalling in development
... activate Toll/TLRs in a developmental ...downstream signalling pathways have been identified in different contexts, this has led to many contradictions: it is unclear whether such discrepancies are due to ...
6
A study of the modulation of Toll-like receptor signalling in macrophages by Annexin-1
... 184 described by Covert et al (Covert et al., 2005), possibly due to interaction of the two signalling pathways. Since AnxA1 -/- BMDMs exhibited an augmented pro-inflammatory state after stimulation of the ...
267
Polymorphisms in members of the Toll like receptor signalling pathway and their role in infectious disease
... It was also revealed that a dramatie inerease in signalling and cytokine production occurred when the TLR6 N30 variant was stimulated with TLR2/6 ligand compared to TLR6 D30 form in s[r] ...
265
The role of non degradative ubiquitination in interleukin 1 and Toll like receptor signalling
... in signalling pathways leading to NF-κB activation is well established, it is also emerging as a potentially key event in IRF ...TLR signalling pathways to NF-κB is underscored by the fact that de- ...
10
Toll‐like receptor signalling induces the expression of serum amyloid A in epidermal keratinocytes and dermal fibroblasts
... peptide receptor-like 1 (FPRL1), and receptor of advanced glycation end-products (RAGE) have been reported as receptors for ...domain-like receptor family pyrin domain-containing 3 may ...
28
Plasmodium yoelii blood stage primes macrophage mediated innate immune response through modulation of toll like receptor signalling
... Semi-quantitive reverse-transcriptase PCR Total RNA was isolated from 1 × 10 6 peritoneal macro- phages from mice injected with P. yoelii 17XL or 17XNL strain, or with nRBCs, one, three and five days after infec- tion ...
8
CD180/RP105 Toll-like Receptor (TLR) mediated signalling in Chronic Lymphocytic Leukaemia
... B-cell signalling. Antigenic binding to the BCR sets in motion the signalling events in which the regulatory subunit p85 provides a binding site for the protein Ras, an event indispensible for further ...
194
Toll-like Receptor 2 Signalling and the Lysosomal Machinery in Barrett's Esophagus
... TLR2 signalling in acid and bile salts exposed BE epithelium cells resulted in an increased expression of lysosomal enzymes and accompanying factors involved in ...TLR2 signalling in the presence of acid ...
13
The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL)
... It has been very well documented that microenvironment plays a major role in the development and progression of chronic lymphocytic leukaemia (CLL). Soluble and cell-bound ligands and receptors in the environment of ...
156
Toll-like receptor 4 signalling and its impact on platelet function, thrombosis, and haemostasis
... including Toll-like receptors (TLRs), for example, Toll-like receptor 4 ...TLR4 signalling in platelets, critically discuss its impact on platelet function, and highlight the ...
14
Implicating Receptor Activator of NF-κB (RANK)/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli
... RANK signalling plays an important role in the regulation of mi- croglial responses to inflammatory ...this signalling pathway may lead to the overstimulation of microglial cells, and, as a consequence, ...
15
Signal transduction by the lipopolysaccharide receptor, Toll like receptor 4
... no signalling role other than acting as a bridge between TLR4 and ...no signalling activity 63 when measuring the activation of NF-jB and IFN-b promoter ...MyD88-independent signalling pathway in ...
10
A dimer of the Toll like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
... The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system ...mammals. Like other class 1 receptors, TLR4 is activated by ligand ...
12
Relationship between toll-like receptor 2 Arg677Trp and Arg753Gln and toll-like receptor 4 Asp299Gly polymorphisms and cytomegalovirus infection
... Diminished signalling in cells that express polymorphic TLRs, particularly when both mutations are expressed on the same protein, may decrease the ability to control infection and thereby increase susceptibility ...
5
Trif related adapter molecule is phosphorylated by protein kinase C epsilon during Toll like receptor 4 signalling
... cell receptor (3), whereas mice deficient in PKC have a defect in T cell receptor signaling, resulting in a severe decrease in NF- B activa- tion and mature T cell proliferation ...of ...
6
Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA(2) signalling
... the Toll-like receptor 4 (TLR4) which serves as a receptor for LPS, although the potential role of TLR4 and associated cell signalling in controlling platelet responses to LPS has not ...
23
Investigation of toll-like receptor tolerance in the regulation of inflammation
... TLR signalling pathways has led to significant developments in elucidating the molecular mechanisms involved regulating TLR signalling in addition to induction of LPS ...TLR4 signalling studies ...
287
Regulation of Toll-like receptor 4-mediated immune responses through Pasteurella multocida toxin-induced G protein signalling
... TLR-mediated signalling events, which can detect and react to extracellular as well as intracellular microbial components ...with signalling cascades of the host ...TLR signalling, induction of ...
15
Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons
... Gross, A., Benninger, F., Madar, R., Illouz, T., Griffioen, K., Steiner, I., Offen, D., Okun, E., 2017. Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced ...
30
Toll-like receptor and antimicrobial peptide expression in the bovine endometrium
... Bacterial PAMPs include LPS, LTA and DNA, so we tested the effects of these and the synthetic Pam3CSK4, to gain an insight into whether the cognate TLRs 1, 2, 4, 6 and 9 are functional in the epithelial cells. We chose ...
12