Trabecular Meshwork
Impact of Pigment Dispersion on Trabecular Meshwork Cells
... Keywords: pigment dispersion syndrome; pigmentary glaucoma; trabecular meshwork; phagocytosis; migration; contraction; cytoskeleton; gene microarray; Rho signaling pathway... Introduct[r] ...
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Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma
... pigmented ciliary body epithelium are crucial in barrier function responsible for ultra-filtration of plasma leading to the production of aqueous humour [21]. Rate of aque- ous humour production, its content and outflow ...
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<p>Regeneration of trabecular meshwork in primary open angle glaucoma by stem cell therapy: a new treatment approach</p>
... the trabecular meshwork (TM) which together with Schlemm’s canal, collector channels, and aque- ous veins, constitute the major outflow pathways in the ...
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Rho- Kinase Inhibitor Y-27632 Decreases the Thickness of Trabecular Meshwork in Juvenile Rats Mod-el Injected with Sodium Hyaluronate
... the trabecular outflow pathway is highly ...of trabecular meshwork in juvenile rats model injected with sodium ...enucleated. Trabecular mesh- work tissue was stained with Hematoxilene-Eosin ...
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Original Article Effects of transforming growth factor-β2 on myocilin expression and secretion in human primary cultured trabecular meshwork cells
... The trabecular meshwork (TM), a reticular tissue in the outflow passage of the aqueous humor (AH), is a major contributor to intra- ocular outflow ...
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Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells
... A primary goal of this study was to determine if glucocor- ticoids with similar potencies but subtly different chemi- cal structures can generate both common and unique subsets of genes in trabecular ...
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A Role for Herpesvirus Entry Mediator as the Receptor for Herpes Simplex Virus 1 Entry into Primary Human Trabecular Meshwork Cells
... The trabecular meshwork (TM), a specialized eye tissue, is the major site for regulation of the aqueous humor outflow. Inflammation of cells in the TM (trabeculitis) due to herpes simplex virus 1 (HSV-1) ...
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Transcription Profiling in Drosophila Eyes That Overexpress the Human Glaucoma-Associated Trabecular Meshwork-Inducible Glucocorticoid Response Protein/Myocilin (TIGR/MYOC)
... the trabecular meshwork- inducible glucocorticoid response protein/myocilin (TIGR/MYOC) are associated with juvenile glaucoma and some cases of adult primary open angle ...
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Genetic association and stress mediated down regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma
... Methods: The study recruited 746 POAG cases and 697 controls distributed into discovery and validation cohorts. In the discovery phase, genome-wide genotype data was generated on Illumina Infinium 660 W-Quad platform and ...
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Link between neurodegeneration and trabecular meshwork injury in glaucomatous patients
... Aqueous humour (AH) is the product of the ciliary body. It provides nutrition for the iris, cornea, lens, and trabecular meshwork [12]. In addition, it also exhibits anti-inflammatory potential, such as ...
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Primary extranodal marginal zone B-cell lymphoma with diffuse uveal involvement and focal infiltration of the trabecular meshwork: a case report and review of literature
... thickening involving the optic disc with a height of 0.37 cm. Two lobulated soft tissue masses were seen around the optic nerve. Fundoscopy revealed deteriorated retinal de- tachment (Figure 1B). The patient and his ...
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Regulation of Phosphatase and Tensin Homolog Expression and Activity by Transforming Growth-Factor Beta in the Trabecular Meshwork Cells: Implications for Primary Open Angle Glaucoma
... Two main types of glaucoma can be classified according to etiology: primary angle- closure glaucoma and primary open-angle glaucoma (POAG). Both types occur when AH is not able to drain from the anterior segment of the ...
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Original Article MiR-184 prevents chronic oxidative stress induced human trabecular meshwork cells apoptosis and cytotoxicity in vitro by targeting hypoxia-inducible factor 1α
... Abstract: Crucial regulatory roles of miRNAs in processing of glaucoma had been identified. This study was con- ducted to investigate the effect of miR-184 in chronic oxidative stress (COS) mediated human ...
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MiR-181a inhibits human trabecular meshwork cell apoptosis induced by H₂O₂ through the suppression of NF-κB and JNK pathways
... protecting trabecular meshwork cells, future experiments that require blocking of these pathways or its upstream pathways upon the inhibition of miR-18a would provide solid evidence about the direct ...
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Original Article miR-192-5p, TGFβ2 and the expression of extracellular matrix moieties in of human trabecular meshwork cells
... Glaucoma ranks as third of the causes of blindnes [1, 2]. Elevated intraocular pressure plays an important role in the pathogenesis of glaucoma [3-5]. Increased resistance of the trabecular meshwork (TM), ...
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Original Article Effects of fasudil on the cytoskeleton of trabecular meshwork cells and outflow facility in bovine eyes
... length (PEFL) in the bovine eyes. A: The red fluorescent microspheres were perfused in the bovine eyes to label the hadeodynamic outflow patterns and visualized by a confocal microscopy under 20× magnifications. Left: ...
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The intrinsic stiffness of human trabecular meshwork cells increases with senescence
... Dysfunction of the human trabecular meshwork (HTM) plays a central role in the age-associated disease glaucoma, a leading cause of irreversible blindness. The etiology remains poorly understood but cellular ...
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Identification, quantification and age-related changes of human trabecular meshwork stem cells
... cultured trabecular meshwork stem cells (TMSCs) expressed putative stem cells markers such as ATP- Binding Cassette G2 protein (ABCG2), NOTCH-1, MUC1 and AnkyrinG ...
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Intraoperative optical coherence tomography and ab interno trabecular meshwork surgery with the Trabectome
... After a temporal 1.7 mm clear cornea incision, the Trabec- tome single-use handpiece was inserted into the anterior chamber and the ACA was visualized using the modified Swan-Jacob goniolens (Ocular Instruments, ...
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Microstructure visualization of conventional outflow pathway and finite element modeling analysis of trabecular meshwork
... to inspect ocular tissues. As one of the frequently-used clinical diagnostic equipment, optical coherence tomography (OCT) has a resolution of 15–25 μm [8], while the light scattering properties of sclera causes imaging ...
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