TRAIL induced Apoptosis
Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells
... and TRAIL combination. The metformin and TRAIL combination was much more potent than either agent alone in inhibiting colony formation, in agreement with the apoptosis ...or TRAIL alone ...
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Combination of AAV-TRAIL with miR-221-Zip Therapeutic Strategy Overcomes the Resistance to TRAIL Induced Apoptosis in Liver Cancer
... including TRAIL itself, and various agonistic monoclonal antibodies against the two human TRAIL death receptors are now in clinical trials as novel cancer therapeutics [3, ...delivered TRAIL to the ...
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Osteoprotegerin (OPG) protects ovarian cancer cells from TRAIL-induced apoptosis but does not contribute to malignant ascites-mediated attenuation of TRAIL-induced apoptosis
... against TRAIL could be related to the presence of high levels of ...attenuating TRAIL- induced apoptosis in colon, breast and prostate cancer cells ...from TRAIL-induced ...
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Inhibition of TRAIL-Induced Apoptosis and Forced Internalization of TRAIL Receptor 1 by Adenovirus Proteins
... these TRAIL-related effects, we employed repli- cation-defective Ad vectors that express E3 proteins ...with TRAIL plus CHX at 24.5 h p.i., and apoptosis was measured at ...by TRAIL, and this ...
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A small compound spindlactone A sensitizes human endometrial cancer cells to TRAIL-induced apoptosis via the inhibition of NAD(P)H dehydrogenase quinone 1
... enhances TRAIL-induced apoptosis in endometrial carcinoma ...and/or TRAIL, and the apoptosis and protein expression in the treated cells were ...
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Ionizing Radiation Sensitizes Leukemic MOLT-4 Cells to TRAIL-induced Apoptosis
... of TRAIL receptors, e.g. NF κ B, p53, STAT1 (5). TRAIL has been found to kill cancer cells selectively, with low to- xicity to normal ...cells. TRAIL induces apoptosis in many haematological ...
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LPS promotes resistance to TRAIL-induced apoptosis in pancreatic cancer
... TLR4 appears to act as a double-edged sword as it has been linked to both cancer inhibition and growth [40]. Whereas TLR4−/− mice showed decreased tumour growth in a murine model of pancreatic cancer, inhib- ition of ...
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Original Article HBs, HBc and MHBs promote TRAIL-induced apoptosis depending on the STAT1 signaling pathway
... in TRAIL-induced apoptosis may depend on the cellular context of infected cells and the regulation of related signal ...of TRAIL could not induce HBV-transfected U3A cell which could not ...
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YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-κB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells
... also induced down-regulation of survivin expression at the post-transcriptional level in human renal Caki ...plus TRAIL-induced apoptosis, whereas survivin overexpression did not alter ...
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Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by a-mangostin, a xanthone derivative
... of TRAIL-resistance in another cell line and to examine the sensitivity to TRAIL-induced apoptosis in breast cancer stem-like cells (CSC-1 and -2), we performed similar experiments by using ...
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Down-regulation of DcR2 sensitizes androgen-dependent prostate cancer LNCaP cells to TRAIL-induced apoptosis
... to TRAIL-induced apoptosis ...enhanced TRAIL-induced apoptosis through the downregulation of cell survival proteins and upregu- lation of death ...the TRAIL ligand is ...
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Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines
... derivatives induced human leukemic MOLT-4 cell apoptosis, but not in U937 ...of TRAIL. 5-MF and 2’-MF enhanced TRAIL-induced apoptosis through the up-regulation of both DRs and ...
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G1P3, an IFN induced survival factor, antagonizes TRAIL induced apoptosis in human myeloma cells
... variable. TRAIL has been proposed to mediate IFN-α2b apoptosis in ...of TRAIL and human myeloma cell survival. While TRAIL was one of the most potently induced proapoptotic genes in ...
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Involvement of PAR-4 in Cannabinoid-Dependent Sensitization of Osteosarcoma Cells to TRAIL-Induced Apoptosis
... ng/ml TRAIL on the level of non-lipidated (LC3-I) and lipidated (LC3-II) forms of LC3, Beclin1 and ...vacuoles induced by WIN treatment, and effect of the autophagic inhibitor, 3-methyladenine ...
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Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL and TRAIL induced apoptosis is cell cycle dependent
... or apoptosis, is central for both devel- opment and tissue homeostasis of ...disorders. Apoptosis can be induced by mem- bers of the tumour necrosis factor (TNF) receptor family through the ...
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Downregulation of DcR3 sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis
... Notes: (A) The expression of DR4 and DR5 was examined by Western blot. GAPHD was used as a loading control. The differences of DR5 among groups were significant (P,0.001). (B) hepg2 cells pretreated with neutralizing ...
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Trichosanthin enhances sensitivity of non-small cell lung cancer (NSCLC) TRAIL-resistance cells
... TRAIL-induced apoptosis via aggregating Fas- associated death domain (FADD) and Caspase 8 ...induces apoptosis via extrinsic or intrinsic apoptotic pathway, also called the DR-mediated or ...
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Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release
... to apoptosis induced through Fas ...or TRAIL, the apoptotic response was assayed by two independent ...reducing TRAIL- and FasL-induced apoptosis in Jurkat ...and ...
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TRAIL R deficiency in mice enhances lymph node metastasis without affecting primary tumor development
... are TRAIL sen- ...were TRAIL resistant (4), as well as the majority of early passage tumor cells obtained from human neoplasias ...also TRAIL resistant (Figure 4A and data not shown). How could the ...
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Eupafolin enhances TRAIL-mediated apoptosis through cathepsin S-induced down-regulation of Mcl-1 expression and AMPK-mediated Bim up-regulation in renal carcinoma Caki cells
... sensitize TRAIL-mediated apoptosis in human renal carcinoma Caki ...μM), TRAIL alone (50 ng/mL), and combined treatment with eupafolin and ...TRAIL. Apoptosis was determined using flow ...
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