Transcription factor NF-κB
Organ specific roles for transcription factor NF κB in reovirus induced apoptosis and disease
... of transcription factor NF-κB complexes containing p50 and p65/RelA ...of NF-κB in this process, we tested the capacity of reovirus to induce apoptosis in mice lacking a ...
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The transcription factor NF-κB control of oncogenesis and cancer therapy resistance.pdf
... of NF- UB, via the expression of the super-repressor IUBK, led to the induction of apoptosis when an oncogenic allele of H-Ras (RasV12) was expressed ...of NF-UB in transformed cells can induce apoptosis ...
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Reovirus-Induced Apoptosis Requires Activation of Transcription Factor NF-κB
... blocks NF-B ...both NF-B activation and apoptosis following reovirus infection (data not ...an NF-B trans-dominant inhibitor blocks reovirus-induced apoptosis and further supports the hypothesis ...
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Constitutive Activation of the Transcription Factor NF-κB Results in Impaired Borna Disease Virus Replication
... scription factor may support viral replication, it is a general belief that NF- B acts antivirally upon infection with RNA viruses such as VSV or influenza virus (11, ...expressed transcription ...
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Control of oncogenesis and cancer therapy resistance by the transcription factor NF κB
... by NF- κ B is presumed to control its major oncogenic functions, as in the case of cyclin D1 and in the antiapoptotic response, noted above, that blocks the ability of oncogenic Ras to induce apop- ...Other ...
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Series Introduction: The transcription factor NF κB and human disease
... the transcription factor NF-kB has attracted widespread interest based on its unusual regulation, the variety of stimuli that activate it, the diverse genes and biological responses that it controls, ...
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Anti Inflammatory properties of Salograviolide A purified from Lebanese plant Centaurea ainetensis
... Interest in alternatives to modern medicine has never been higher than it is now, and a large part of this interest revolves around the use of medicinal plants. Many of the anti-inflammatory activities of some medicinal ...
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Original Article Expression of NF-κB and PCNA in gastric mucosa-associated lymphoid tissue lymphoma and its clinical significance
... Nuclear transcription factor (NF-κB) is a kind of widely present in a variety of cell nuclei of eukaryotic transcription factors, studies have shown that it is involved in ...
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Oncogenic Signaling Pathways in Cancer: An Overview Afshin Derakhshani 1# , Zeinab Rostami 2# , Sina Taefehshokr 3, Hossein Safarpour4 , Reza Vaezi Astamal 5, Nima Taefehshokr6 , Nazila Alizadeh 7, Antonella Argentiero8 , Nicola Silvestris 9* Behzad Baradaran 10*
... colony-stimulating factor 1 (CSF1), a key signal that induces macrophages to secrete more ...the transcription factor NF-κB [199] is essential, because it can support cell proliferation ...
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NF κB determines localization and features of cell death in epidermis
... layers, NF-κB translocates from the cytoplasm to the nucleus and induces target gene ...tissues, NF-κB acti- vation in these cells suggests that this transcription factor ...
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A systems biology approach to explore the dynamics and interactions of the NF-κB signalling pathway
... significance of this remains unclear. In the study by Sung et al., it was further observed that there was no increase in gene expression for ten genes of interest following LMB treatment, including IκBα. The argument ...
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... the NF-κB-dependent inflammatory pathway increased TNF-α expression in OSAHS patients, and the activation of the HIF-1-dependent adaptive pathway increased the serum erythropoietin (EPO) levels in severe ...
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Anti inflammatory activity of the ethanol extract of Dictamnus dasycarpus leaf in lipopolysaccharide activated macrophages
... [5]. NF-κB is a heterotrimeric complex composed of p50, p65, and I κ B- α , and its activation is the key event of many proinflammatory transcriptional programs that finally lead to the development of a ...
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Molecular mechanisms of HIV latency
... HIV transcription is reactivated so that antiretroviral therapy and the immune system clear the infection, has been proposed as one approach to curing ...viral transcription factors in such a way as to ...
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NF κB modulated miR 130a targets TNF α in cervical cancer cells
... Nuclear factor- κ B (NF- κ B) is a nuclear transcription fac- tor that regulates the expression of a large number of genes associated with inflammation [1,2], tissue damage and repair [3,4], cell ...
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NF κB: pivotal mediator or innocent bystander in atherogenesis?
... of transcription factors may be critical in both the initi- ation and expansion of lesions, as well as in protecting the vessel wall from the formation of atherosclerotic ...tion factor, NF- κ B, ...
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Androgen receptor activity modulates responses to cisplatin treatment in bladder cancer
... a transcription factor that induces anti- apoptotic proteins, has been considered as a key molecule for CDDP resistance ...or NF-κB expression, and ...of NF-κB and its binding to ...
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Original Article GF109203X attenuates RANKL-induced osteoclastogenesis and suppresses osteolysis in a mouse model
... sis factor (TNF) super family, and is primarily secreted by the ossification cells, T lympho- cytes, and B lymphocytes ...nuclear factor kappa B (NF-κB) into the nucle- us, which prevents ...
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Radiation Resistance In Radiotherapy : A Review
... of NF- κB which is a transcription factor that increases tumor growth, degrades ionizing radiations as well as resist the chemotherapeutic effect during ...that NF- κB is ...
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Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
... growth factor starvation ...of transcription factor nuclear factor kappa B (NF-κB) in a subset of aged cells and plays a role in mediating inflammatory ...
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