transcriptional repressor
Functional and structural insights into MmyJ, An ArsR like transcriptional repressor
... These species were found to be resistant to the Mm they produced via the Mmr protein [93, 94], later found to operate as a membrane integral efflux pump through comparison with the known efflux protein Tcr, which ...
184
Identification of a Novel Transcriptional Repressor Encoded by Human Cytomegalovirus
... Localization of pUL34. As a DNA-binding protein, pUL34 was predicted to localize to the nucleus of cells. Amino acid analysis identified three potential nuclear localization signals within the UL34 open reading frame ...
8
Conversion of the LIN-1 ETS Protein of Caenorhabditis elegans from a SUMOylated Transcriptional Repressor to a Phosphorylated Transcriptional Activator
... a transcriptional repressor to a transcriptional activator? Activation of ERK might result in decreased SUMOylation of ...with transcriptional repressors. In particular, the EGL-27 ...
15
Repression of YdaS Toxin Is Mediated by Transcriptional Repressor RacR in the Cryptic rac Prophage of Escherichia coli K-12
... The genome of the laboratory strain E. coli K-12 comprises nine cryptic prophages which constitute 3.6% of its total genome. Among these prophages is a cryptic prophage called rac. The rac prophage is 23 kb long and ...
10
Implication of intracellular localization of transcriptional repressor PLZF in thyroid neoplasms
... confirm PLZF expression in N, AL, and PTC, and showed that PLZF was expressed at quite high levels in PTC compared with N and AL. PLZF is known to be a transcriptional repressor, and is associated with ...
8
The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor
... Our results also tested if the zinc fingers are necessary for AML1-ETO to inhibit gene expression. When compared with AML1-ETO, we found that AML1-ETO ∆ ZF is slightly less potent at repressing dpn expression but is able ...
10
FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2
... mammary epithelial cells increased SKP2 expression. We also show that Foxp3 directly interacted with and repressed the Skp2 promoter. Moreover, the analysis of over 200 primary breast cancer samples revealed an inverse ...
10
Androgen receptor functions as transcriptional repressor of cancer associated fibroblast activation
... downmodulated AR expression in dermal fibroblasts underlying premalignant skin cancer lesions (actinic keratoses and dysplastic nevi) as well as in CAFs from the 3 major skin cancer types, squamous cell carcinomas ...
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Characterizing the Interaction Between Human Adenovirus E1A and the Transcriptional Repressor BS69
... These transcriptional units occupy both strands of the adenoviral genome, with E1A, E1B, E3, IX, and L on the rightward transcription strand, while E2A, E2B, E4, IVa2, and U are on the leftward transcription ...
172
Role of MeCP2, DNA methylation, and HDACs in regulating synapse function
... a transcriptional repressor by binding to target gene pro- moters and silencing their ...the transcriptional repressor function of MeCP2 and suggests that it may also function as a ...
7
VITAMIN A, RETINOIC ACID AND TAMIBAROTENE, A FRONT TOWARD ITS ADVANCES: A REVIEW
... The experimental results demonstrated that, indeed, PML-RARA is a stronger transcriptional repressor that is able to impose its silencing effect on chromatin state even in the absence of RXR. Only ...
10
MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma
... and point towards a functional role of CD9 promoter methylation in tumors lacking MYCN amplifications. We next used several different neuroblastoma cell and mouse models to investigate the nature of this relationship and ...
16
Engineering metabolite-responsive transcriptional factors to sense small molecules in eukaryotes: current state and perspectives
... hypothesis, transcriptional repressor domain could be fused with dCas9 to enhance the repression effect [51, ...The repressor domain, theoretically, should bind its cognate operator region and bring ...
13
Implementation of a CRISPR-Based System for Gene Regulation in Candida albicans
... a transcriptional repressor (Nrg1) or activator (Gal4), we were able to show specific repression or activation of the tester gene CAT1, encoding the cytosolic ...improved transcriptional activation ...
13
Transcriptional co-repressor response of Arabidopsis thaliana to different abiotic stress
... a transcriptional repressor ...as transcriptional repressor to repress the expression of genes involved in plant response to cold and ...
84
The 19S Proteasome Activator Promotes Human Cytomegalovirus Immediate Early Gene Expression through Proteolytic and Nonproteolytic Mechanisms
... Proteasomes are large, multisubunit complexes that support normal cellular activities by executing the bulk of protein turnover. During infection, many viruses have been shown to promote viral replication by using ...
9
Studies on the core binding factor complex in patients with acute myeloid leukaemia
... In t(8;21) AML, the ETO portion of the fusion protein has been shown to recruit a transcriptional repressor complex (see Chapter 1), thereby repressing transcription from[r] ...
216
Two component signal transduction system CBO0787/ CBO0786 represses transcription from botulinum neurotoxin promoters in Clostridium botulinum ATCC 3502
... a transcriptional repressor of the neurotoxin gene cluster in ATCC 3502, we examined the binding of the recombinant CBO0786 protein to probes that encompassed the intergenic region between ha33 and botR ...
11
Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA.
... Because pGAL4-EBNA3C aa11-992 encodes such a large protein ( . 1,000 aa), it is conceivable (though unlikely) that repression is due to the fusion protein sterically blocking the promoter. Therefore, two constructs, ...
9
Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
... and suicide [174,175]. Since the C(-1019)G polymorph- ism is located in a 26-bp palindrome, we addressed whether this palindrome could bind protein in nuclear extracts of raphe RN46A cells, and showed a specific complex ...
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