transformation defective
Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells.
... However, the formation of a complete MT/cellular protein complex and the activation of tyrosine kinase are not sufficient to cause transformation, since the transformation-defective muta[r] ...
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Transformation-defective mutants of Rous sarcoma virus with longer sizes of genome RNA and their highly frequent occurrences.
... 2 Transformation-Defective Mutants of Rous Sarcoma Virus with Longer Sizes of Genome RNA and Their Highly Frequent Occurrences MITSUAKI YOSHIDA,'* MAKOTO YAMASHITA,' AND AKIO NOMOTO' Dep[r] ...
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A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity.
... Since the single base pair mutation at amino acid 248 resulted in an MTAg that was completely transformation defective despite possessing wild-type levels of kinase activities, this sugg[r] ...
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A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling
... mutants defective in transformation. dl1015 is known to be transformation defective (38, ...of transformation in focus formation assays ...
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Restriction enzyme analysis of partially transformation-defective mutants of acute leukemia virus MC29.
... However, tdlOA, tdlOC, and tdlOH yielded only the characteristic BamHI fragments, implying that the mutants lacked the ClaI site found in wild-type MC29, Q8.. It is not clear from these [r] ...
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Deletions Within the Transformation-Specific RNA Sequences of Acute Leukemia Virus MC29 Give Rise to Partially Transformation-Defective Mutants
... Previous oligonucleotide mapping had shown that the relative map order of the myc-specific oligonucleotides is conserved among all members of the MC29 subgroup of acute leukemia viruses [r] ...
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Transformation of rodent cells by DNA extracted from transformation-defective adenovirus mutants.
... GRAHAM Departments of Pathology and Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1 Complementation group II host range mutants of adenovirus type 5 which map in early re[r] ...
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Middle tumor antigen of polyomavirus transformation-defective mutant NG59 is associated with pp60c-src.
... When NG59RA-infected MEC were extracted in buffer D modified RIPA buffer, immune complex kinase assays of either T serum or PAb815 immunoprecipitates yielded MTAg as the major in vitro p[r] ...
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Isolation of transformation-defective, replication-nondefective early region 1B mutants of adenovirus 12.
... 154 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We isolated three adenovirus 12 early region 1B mutants in2O5B, in2O5C, and d1205 by ligation of the cleaved DNA-pro[r] ...
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Transformation-defective mutants of Rous sarcoma virus with src gene deletions of varying length.
... Three of seven td mutants appeared to recombine with a mutant of Rous sarcoma virus Schmidt-Ruppin, which has a temperature-sensitive sarcoma src gene and is termed ts68, to give rise to[r] ...
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Distinguishable transformation-defective phenotypes among temperature-sensitive mutants of Rous sarcoma virus.
... Although the PTD mutant-infected cells, unlike cells infected with other transformation mutants, exhibit a cell-bound plasminogen activator protease at the nonpermissive temperature, thi[r] ...
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Isolation of a Transformation-Defective Deletion Mutant of Moloney Murine Sarcoma Virus
... Heteroduplex analyses of Mo-MSV 124 RNA, as well as of the RNAs of other Mo-MSV strains, have further indicated that the Mo-MSV genome contains terminal regions closely related to Mo-MuL[r] ...
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Simian virus 40 large T antigen induces or activates a protein kinase which phosphorylates the transformation-associated protein p53.
... These data suggest i that SV40 large T antigen induces or activates a protein kinase, one substrate of which is p53, ii that transformation-defective mutants are impaired in kinase induc[r] ...
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Characterization of T antigen in cells infected with a temperature-sensitive mutant of simian virus 40.
... The present study demonstrates that a molecular form of T antigen induced by ts 900, a transformation-defective ts mutant of SV40 29, is more heat labile than that induced by WT virus, i[r] ...
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Identification of the viral sequence required for the generation of recovered avian sarcoma viruses and characterization of a series of replication-defective recovered avian sarcoma viruses.
... This conclusion has been based on i the analyses of the genomic RNAs of rASVs, transformation-defective viruses, and Schmidt-Ruppin Rous sarcoma virus subgroup A SR-A, the parental virus[r] ...
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Characterization of some isolates of newly recovered avian sarcoma virus.
... Transformation-defective mutants of Rous sarcoma vi- Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The characteristics described above suggest that rASV's have gained[r] ...
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Temperature-sensitive mutants of herpes simplex virus type 1 defective in lysis but not in transformation.
... Mutants representing all seven complementation groups failed to grow in either of these two transformed cell lines at the nonpermissive temperature, as measured by plaque formation on th[r] ...
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Quantitative Characteristics of the Transformation of Hamster Cells by PARA (Defective Simian Virus 40)-Adenovirus 7
... HEF cell cultures transformed by the hybrid virus under the conditions of method B adsorption in suspension contained twice as many transformed foci as cells transformed as a result of v[r] ...
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Lytic Replication-Defective Kaposi's Sarcoma-Associated Herpesvirus: Potential Role in Infection and Malignant Transformation
... harboring defective KSHV would be ideal for such character- ...of defective KSHV in these cul- tures (data not ...detect defective KSHV if it is only present in a subset of cells that harbor high ...
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Reduced microfilament organization in adenovirus type 5-infected rat embryo cells: a function of early region 1a.
... Mutants defective in Ad5 early genes were used to show that reduced microfilament organization was a function of the Ad5 transformation early gene la Ela and did not require expression o[r] ...
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