Transgenic and knockout mice
Wound-healing studies in transgenic and knockout mice
... in Transgenic and Knockout Mice Richard Grose* ,1,2 and Sabine Werner 2 Injury to the skin initiates a cascade of events including inflammation, new tissue formation, and tissue remodeling, that ...
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Effect of fetal hemoglobin on microvascular regulation in sickle transgenic knockout mice
... sickle transgenic-knockout mice Dhananjay ...sickle transgenic-knockout Berkeley (BERK) mice (which express exclusively human a- and b S -globins with <1% g-globin levels) are ...
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Somatostatin Receptor 1 and 5 Double Knockout Mice Mimic Neurochemical Changes of Huntington s Disease Transgenic Mice
... Methods and Findings: To delineate subtype selective biological responses we have here investigated changes in SSTR1 and 5 double knockout mice brain and compared with HD transgenic mouse model ...
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Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer?
... first knockout of the mouse p53 tumor suppressor gene (designated Trp53) was published, much has been learned about the contribution of p53 to biology and tumor suppression in the breast through the use of p53 ...
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A Critical Analysis of the Interplay between Cytochrome P450 3A and P-Glycoprotein: Recent Insights from Knockout and Transgenic Mice
... mouse knockout and trans- genic models can be extremely useful in addressing var- ious pharmacokinetic and toxicological questions, in- cluding ways to pharmacologically modulate transporter or metabolic ...
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Comprehensive behavioral phenotyping of calpastatin-knockout mice
... KO mice. In a previous behavioral study, μ-calpain KO mice displayed more rearing behavior before condition- ing in a fear-conditioning chamber compared with WT mice ...KO mice and CS-KO ...
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Lung fluid transport in aquaporin 5 knockout mice
... the minimal expression of AQP5 in lung at the time of birth, and the delayed appearance of AQP5 after birth suggests that AQP5 is not involved in perinatal alveolar fluid clearance (16–18). The tissue-specific expression ...
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Antiviral immune responses in CTLA4 transgenic mice.
... The role of accessory molecules such as CD28 and B7.1 as well as GP39 and CD40 in lymphocyte interactions has been analyzed in several model systems in vivo and in vitro using blocking monoclonal antibodies (MAb) (60) or ...
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Transgenic rescue of insulin receptor–deficient mice
... receptor knockout mice from neonatal death, prevents diabetes in a majority of animals, and normalizes adipose tissue content, lifespan, and reproductive ...contrast, mice with insulin receptor ...
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Pdx1 restores β cell function in Irs2 knockout mice
... In mice, the Irs2 branch of the insulin/Igf signaling system mediates peripheral insulin action and pancreatic β cell growth and ...–/– mice might be related to dys- function of MODY-related transcription ...
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In vivo blood flow abnormalities in the transgenic knockout sickle cell mouse
... normal mice with that in transgenic knockout sickle cell mice that have erythrocytes containing only human hemo- globin S and that exhibit a degree of hemolytic anemia and pathological ...
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What have transgenic and knockout animals taught us about respiratory disease?
... of mice itself, but results from our continued ignorance of the disease process and how to improve the modelling of complex interactions between different inflammatory mediators that underlie clinical ...
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Sleep in Kcna2 knockout mice
... (HZ), p = 0.047). KO pups also did not show clear differ- ences from their littermates in their ability to recover from surgery and anesthesia. Specifically, the required dose of anesthetic and wake-up time (time to ...
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Generation of Fgfr3 Conditional Knockout Mice
... out mice, Fgfr3 is disrupted in all cells, which prevents the effort for further stud- ying of the role of FGFR3 in specific types of cells and their corresponding cellular and molecular mechan- ...null ...
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Generation of Smurf2 Conditional Knockout Mice
... C57/BL6 mice to generate male chimeric mice, which were bred with female C57BL/6 mice to produce F1 agouti offsprings carrying one copy of the targeted Smurf2 floxneo ...
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How to construct transgenic mice
... Generation of gene deficient mice „knock-out“ 4.. Future of knock-out mice??.[r] ...
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How to construct transgenic mice
... Generation of gene deficient mice „knock-out“... December 2002.[r] ...
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How to construct transgenic mice
... Generation of Transgenic Mice holding pipette cloned gene holding pipette cloned gene 1-cell embryos at pronuclear stage injection pipette 1-cell embryos at pronuclear stage injection [r] ...
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Transgenic mice the early days
... that transgenic methodology could be used to explore many different experimental questions and we could not resist the opportunities to collaborate with specialists throughout the country on these various ...a ...
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Using TALENs to Knockout H2A.Lap1 Function in Mice
... 159 TALEN, together with the requirement of flanking 5' thymine, not only have given TALEN the advantage over ZFN, but also over CRISPR. The main objective of this chapter was to determine whether TALENs could cause any ...
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