transgenic mouse model
Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background
... engineered mouse models for HCC, however, generally do not feature liver fibrosis, which is a critical discrepancy between human HCC and murine models ...simple transgenic mouse model of HCC ...
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Dantrolene is neuroprotective in Huntington's disease transgenic mouse model
... chromosome transgenic mouse model of HD ...(SCA3) mouse models and demonstrated that treatment with dantrolene, a ryanodine receptor antagonist and clinically relevant Ca 2+ signaling ...
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The effects of Rhes, a striatal specific protein, on the expression of behavioral and neuropathological symptoms in a transgenic mouse model of Huntington's disease
... huntingtin protein (mHtt) is ubiquitously expressed in HD patients, cellular degeneration occurs only in neurons within the striatum and cerebral cortex. The Ras homolog Rhes is expressed very selectively in the precise ...
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Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer’s disease
... Background: Immunologic abnormalities have been described in peripheral blood and central nervous system of patients suffering from Alzheimer ’ s disease (AD), yet their role in the pathogenesis still remains poorly ...
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The ontogeny of myometrial stem cells in OCT4-GFP transgenic mouse model
... generalized transgenic mouse model, we could follow the expression of this primitive stem-cell marker with green fluores- ...for mouse stem cells, as we previously described in human and rat ...
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Multiparametric Spectroscopic Photoacoustic Imaging of Breast Cancer Development in a Transgenic Mouse Model
... Figure 1. Flow chart summarizes the workflow of spectral photoacoustic imaging data set acquisition and data analysis in transgenic mice. (1) Co-registered transverse ultrasound and photoacoustic images at 17 ...
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Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease
... vitro model of advanced AD a decrease of peroxi- somes in hippocampal neurons was reported, while induction of peroxisomal proliferation attenuated Aβ- dependent toxicity ...a transgenic mouse ...
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Expression profile and down-regulation of argininosuccinate synthetase in hepatocellular carcinoma in a transgenic mouse model
... double transgenic mice, sinusoids were narrower and were branched, and formed multi- layered HCC morphology (Figure 6D, yellow ...double transgenic mice developed histologically-verified HCC in which ASS ...
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Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
... NF B has been shown to regulate BACE-1 expression level [11,17,13-15], the rate limiting enzyme responsible for the production of Ab. For this reason, we investi- gated whether NF B inhibition could lead to an inhibi- ...
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Generation of a new transgenic mouse model for assessment of tau gene silencing therapies
... Mice from the Y-74 line of TUL mice were crossed to mice that express the tet-Transactivator (tTA) under the CamKIIα promoter to produce mice that exclusively ex- press the TUL construct in forebrain. From the design of ...
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Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model
... Histology. Sections of mouse mammary glands were surgically excised and immediately placed in neutral buffered formalin. Paraffin sections were prepared and stained with hematoxylin and eosin. Sec- tions were ...
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Microarray analysis of gene expression in the liver of transgenic mouse model of HCV infection
... younger transgenic mice have no detectable HCV proteins, at 3 months of age an increasing number of hepatocytes expressing Core, E1, E2 proteins around central veins are observed along with appearance of both ...
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Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells
... ko mouse lines [37] and the wildtype (WT) mouse line expressing the Ptprc a ...PSAPP transgenic mice express a chimeric mouse/ human amyloid precursor protein (Mo/HuAPP695swe) and a mutant ...
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A transgenic mouse model of systemic lupus erythematosus
... IFN-y transgenic mice With the exception of one animal, increased levels of anti-dsDNA antibodies were not accompanied by production of autoantibodies against the ENA ...single mouse with anti-ENA ...
200
Physiology of anergic CD8 T cells in a transgenic mouse model
... cells. Transgenic CD4 T cells specific for OVA peptide rendered tolerant in irradiated hosts after several rounds of antigenic stimulation in vivo, were found unable to proliferate and produce IL-2 upon antigenic ...
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Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma
... determined transgenic mouse strain in which ligand-dependent acti- vation of TGF-β signaling occurs selectively in fibroblasts (Tβ ...in transgenic cells, but for transcripts induced at 12 hours when ...
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The effects of chronic simvastatin treatment on the expression of behavioral symptoms in a transgenic mouse model of Huntington’s disease
... a mouse model containing a particular fragment of the full length HD gene indicates it is not the aggregates themselves that are driving neuronal ...The model displays early and widespread neuronal ...
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The generation and analysis of mice bearing a human alpha-1-antitrypsin gene construct containing the Z mutation
... a transgenic mouse model of the AAT related liver disease the endogenous mouse AAT genes have to be ...best model of the disease would probably be achieved by inactivation of the ...
315
Genetic mouse models of Alzheimer's disease
... Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APPSW: transgenic mouse model for Alzheimer’s disease.. Postina R, Schroede[r] ...
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Clinical significance of epithelial-mesenchymal transition
... a transgenic mouse model of pancreatic beta-cell car- cinogenesis, the switch from noninvasive adenoma to in- vasive carcinoma is associated with a loss of E-cadherin expression [82]; moreover, it ...
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