transient receptor potential (TRP) channel
TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL: AN EMERGING TARGET FOR PAIN
... the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that detect noxious stimuli and transduce a diverse range of physical and chemical energy into action ...
10
Human transient receptor potential (TRP) channel expression profiling in carcinogenesis
... functional potential of TRPs might be especially important for our understanding of the pathogenesis of several diseases, and therefore TRP channels have been identified as new potential therapeutic ...
9
Original Article Changes of stretch-activated channel-transient receptor potential channels in atrial myocardium of rabbits with heart failure
... Abstract: Transient receptor potential channels (TRPC) are shown recently to play an important role in the develop- ment of heart failure and ...of transient receptor potential ...
6
<p>Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling</p>
... Transient receptor potential cation channel protein 6 (TRPC6) is colocalized in the kidney podocyte glomerular slit diaphragm with the protein, ...TRPC6 channel is induced by ...
10
Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function
... the transient receptor potential melastatin member 8 (TRPM8) channel has emerged as a promising prognostic marker and putative therapeutic target in prostate cancer ...release channel, ...
12
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding
... Here we provide evidence for a critical role of the transient receptor potential cation channel, subfamily V, member 4 (TRPV4) in normal bladder function. Immunofluorescence demonstrated TRPV4 ...
11
Ocular transient receptor potential channel function in health and disease
... Transient receptor potential (TRP) channels sense and transduce environmental stimuli into Ca 2+ transients that in turn induce responses essential for cell function and ...conditions ...
12
Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation
... downstream molecules including kinases, phosphatase or other TRP channels [1, 2]. As well, the N-terminus of TRPV1 or TRPA1 channels contains several ankyrin repeats that would bind with intracellular proteins ...
12
The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model
... Our data confirm the contribution of TRPA1 to NTG- induced hyperalgesia. In agreement, other groups showed that antisense mRNA for TRPA1 prevents carra- geenan-induced inflammatory hyperalgesia, suggesting that ...
9
Polymodal roles of transient receptor potential channels in the control of ocular function
... aberrant transient rather than sustained retinal membrane depolarization ...the channel eliciting this altered response has a homology with TRP ...The TRP prototype was cDNA cloned from ...
10
Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells
... accordance with [55]. Cells were cultured overnight on glass cover slips and loaded with 1 μM Fura-2/ AM at 37°C for 20 min. Glass coverslips were placed in a perfusion chamber in a Zeiss Axio Observer.A1 fluorescence ...
11
Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma
... CD4 + T cells are thought to play a prominent role in the development of allergic asthma, thus targeting them is considered to be a viable means to combat the disease. Re- cently it has been shown that human and mouse ...
10
Transient receptor potential (TRP) gene superfamily encoding cation channels
... of TRP channels in the eye elicits responses needed for ocular sensory and cellular ...mammals, TRP channel subunit pro- teins are encoded by 27 genes and are grouped into six different subfamilies, ...
9
The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies
... A recently published comprehensive review article summarizes menthol’s biological activities, including its cooling effect and its analgesic, antifungal, antibacterial, antipruritic, anticarcinogenic, anti-inflammatory, ...
12
Expression of transient receptor potential channel 6 in cervical cancer
... Recently, it has been reported that TRPC6 is also expressed in esophageal, gastric, breast, and prostate tissue, where elevated channel expression has been implicated in cancer of these organs. The role of TRPC6 ...
6
OConor_unc_0153D_14695.pdf
... Transient Receptor Potential (TRP) cation channels serve as polymodal sensors in mammalian cells and come in six subtypes: TRPC (“canonical”), TRPV (“vanilloid”), TRPM (melastatin”), TRPP ...
98
Capsaicin in metabolic syndrome
... on transient receptor potential vanilloid channel 1 ...proliferator-activated receptor α (PPARα), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 ...
21
Original Article Effect of cold and hot compress on neutrophilic migration to the site of doxorubicin extravasation
... C5a receptor (CD88), interleukin-8 receptor (IL-8RA), and transient receptor potential cation channel subfamily V member 1 (TRPV1) were also ...
10
Inhibition of store-operated calcium entry in microglia by helminth factors: implications for immune suppression in neurocysticercosis
... (transient receptor potential channel 1 (TRPC1) and ORAI Ca 2+ release-activated Ca 2+ modulator 1 (ORAI1)) and associated signaling pathways in ...
12
In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model
... selective transient receptor potential cation channel, member A1 (TRPA1) antagonist identified during a focused drug discovery ...TRPA1 channel heterologously expressed in human ...
12