Translation Initiation
Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in non-Hodgkin lymphoma
... D3 translation through suppression of the highly translationally active ...of translation initiation whereas joining of the ribosomes to the pre-initiation complex is ...cap-dependent ...
14
Alternative Translation Initiation of Theiler’s Murine Encephalomyelitis Virus
... on translation initiation in FMDV. FMDV translation naturally occurs at two in-frame AUGs separated by 84-nt, with usage varying among different viral isolates; the two AUGs encode either a full- ...
8
The Biological Roles of Translation Initiation Factor 3b
... protein translation level increases [31]; and (2) the translation initiation factor complex regulates the translation of many specific mRNAs involved in many significant cellular processes, ...
6
Global mRNA selection mechanisms for translation initiation
... and translation (Figure 6A; Additional file ...and translation factors, such as TEF1, TEF2, EFB1, TIF1 and TIF2, which are amongst the most highly expressed and hence abundant proteins in the ...tion ...
21
Genetic Interactions of Yeast Eukaryotic Translation Initiation Factor 5A (eIF5A) Reveal Connections to Poly(A)-Binding Protein and Protein Kinase C Signaling
... tles between the nucleus and the cytoplasm, is required for mRNA Posas, F., M. Takekawa and H. Saito, 1998 Signal transduction by 3 ⬘ -end formation in yeast. Genes Dev. 11: 2545–2556. MAP kinases in budding yeast. Curr. ...
13
Tumor suppression by small molecule inhibitors of translation initiation
... Eukaryotic translation is regulated by the eukaryotic translation initiation factors (eIFs), features of mRNAs, and signaling ...other translation initiation factors to form the 48S ...
13
Dengue Virus Utilizes a Novel Strategy for Translation Initiation When Cap-Dependent Translation Is Inhibited
... cap-dependent translation, such as apoptosis or entry into mitosis, several cellular transcripts ...cap-independent translation (10, 54, ...of translation initiation during certain stages of ...
11
Small-molecule targeting of translation initiation for cancer therapy
... of translation initiation can be used for cancer treatment and perhaps prevention in high-risk ...of translation initiation inhibitors being developed as well as progress in resolving the ...
12
Experimental Analysis of Mimivirus Translation Initiation Factor 4a Reveals Its Importance in Viral Protein Translation during Infection of Acanthamoeba polyphaga
... as translation components, triggering considerable interest in evolutionary biology ...central translation- related ...in translation initiation, the most important step in translation, ...
13
Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... the initiation factors involved in the cap-dependent translation initiation may also be used in the internal initiation would signify that picornaviruses have not developed a new form of ...
6
Efficient Translation of Rotavirus mRNA Requires Simultaneous Interaction of NSP3 with the Eukaryotic Translation Initiation Factor eIF4G and the mRNA 3′ End
... vitro translation assay in which little mRNA degradation occurs (7, ...cellular translation initiation ...the translation initiation complex eIF4F by interacting simultaneously with ...
8
Translation initiation at a downstream AUG occurs with increased efficiency when the upstream AUG is located very close to the 5' cap.
... To determine whether the short length of the untranslated leader of this mRNA affects the efficiency of translation initiation at the LP1 initiation signal, monkey cells were transfected[r] ...
5
Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... Gallie, D. R., H. Le, C. Caldwell, R. L. Tanguay, N. X. Hoang Lengyel, P., 1993 Tumor-suppressor genes: news about the inter- et al., 1997 The phosphorylation state of translation initiation feron ...
10
Ribosome signatures aid bacterial translation initiation site identification
... the translation initiation landscape of ...of translation initiation, while the previously matching annotations do ...lacked initiation codons, of which we were able to re-annotate 15 ...
14
Translation Initiation from Conserved Non AUG Codons Provides Additional Layers of Regulation and Coding Capacity
... good initiation contexts and in the same frame with the mORF are present 5= of the apparently inhibitory ...potential translation initiation at the NCC would bypass the regulatory effects of the ...
17
Modulation of Translation Initiation Efficiency in Classical Swine Fever Virus
... To analyze the function of domain II of the IRES for the virus, selected deletions (II ⌬ 2, II ⌬ 5, and II ⌬ 6) were introduced into a full-length CSFV cDNA in an attempt to rescue viable viruses. The full-length CSFV ...
12
Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro.
... To further characterize La activity in translation and to identify other potential limiting factors, we assayed the ability of La protein as well as purified initiation factors, eIF-2, g[r] ...
7
The sequence context of the initiation codon in the encephalomyocarditis virus leader modulates efficiency of internal translation initiation.
... The efficiency of use of EMCV AUG-11 as well as the occurrence of initiation at downstream AUGs was assessed by transient expression in COS-1 monkey cells transfected with the various co[r] ...
9
Nucleotide sequences important for translation initiation of enterovirus RNA.
... Since viruses PV1MIC-DA21 and PV1SabIC-DA21 have been shown to be less efficient in virus-specific protein synthesis in infected cells 5, the activities of deletion RNAs of CVB1 acting a[r] ...
7
Selective translation initiation on bicistronic simian virus 40 late mRNA.
... It thus appears that the Ad2MLP can effect differential translation of agnoprotein and VP1, possibly because of the small segment of the adenovirus type 2 major late leader sequence in t[r] ...
5