Translation initiation-factor
Influenza A Virus-Induced Degradation of Eukaryotic Translation Initiation Factor 4B Contributes to Viral Replication by Suppressing IFITM3 Protein Expression
... cellular translation machinery and its role during the viral infection have come into the focus of interest ...the translation of host mRNAs, thereby suppressing host innate defenses ...eukaryotic ...
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Original Article Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia
... eukaryotic translation initiation factor 3 subunit B (EIF3B) on cell proliferation, migration, and apoptosis as well as the underlying mechanism in acute myeloid leukemia ...
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The IE180 Protein of Pseudorabies Virus Suppresses Phosphorylation of Translation Initiation Factor eIF2α
... We have previously shown that the porcine alphaherpesvirus pseudorabies virus (PRV) efficiently interferes with phosphoryla- tion of the eukaryotic translation initiation factor eIF2 ␣ . Inhibition ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... ~2.7 × 10 6 clones screened, 8 positive clones were iso- lated using the most stringent reporter selection. To ret- est protein-protein interaction in yeast, library plasmids were rescued and cotransformed into the AH109 ...
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The Eukaryotic Translation Initiation Factor 4GI Is Cleaved by Different Retroviral Proteases
... eukaryotic initiation factors participate in both mRNA binding and scanning by the small ribosomal subunit of the 5⬘ untranslated sequence of the ...the translation initiation factor eIF4G, ...
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Revisiting an old acquaintance: role for eIF5A in diabetes
... Dysfunction of pancreatic islet β cells underlies both type 1 and type 2 diabe- tes and appears to result in part from the local release of proinflammatory cytokines. An improved understanding of the mechanisms that ...
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Interaction of Translation Initiation Factor eIF4B with the Poliovirus Internal Ribosome Entry Site
... the initiation factors eIF4B, eIF4G, and eIF4A to picornaviral IRES elements had been reported only for type II IRES elements, namely, those of FMDV (23, 29, 45, 46) and EMCV (19, ...of initiation factors ...
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Translational Control of the Abundance of Cytoplasmic Poly(A) Binding Protein in Human Cytomegalovirus-Infected Cells
... host translation factor abun- dance was obtained using a well-characterized IE1-deficient virus ...host translation initiation factor concen- tration in HCMV-infected cells is IE1 ...
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Vesicular Stomatitis Virus Oncolysis of T Lymphocytes Requires Cell Cycle Entry and Translation Initiation
... mRNA translation by binding to and inhibiting ...the translation initiation factor ...blocking translation initiation of 5 ⬘ - capped and/or 5 ⬘ -TOP mRNAs (13, 57, ...
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Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
... eukaryotic translation initiation factor 4E (eIF4E) cooper- ates with c-Myc during lymphomagenesis, induces drug resistance, and is a genetic modifier of the rapamycin response, we have investigated ...
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Helper Component Proteinase of the Genus Potyvirus Is an Interaction Partner of Translation Initiation Factors eIF(iso)4E and eIF4E and Contains a 4E Binding Motif
... eukaryotic translation initiation factor eIF4E and the isoform eIF(iso)4E, which interact with viral genome-linked protein ...with translation initiation factors and were detrimental to ...
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Herpes Simplex Virus 1 Infection Activates the Endoplasmic Reticulum Resident Kinase PERK and Mediates eIF-2α Dephosphorylation by the γ134.5 Protein
... of translation initiation factor eIF-2 (eIF-2 ␣ ...exchange factor eIF-2B, thus seques- tering eIF-2B in an inactive complex with phosphorylated eIF-2 and GDP (13, ...
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Specific Inhibition of the PKR-Mediated Antiviral Response by the Murine Cytomegalovirus Proteins m142 and m143
... (PKR) and the oligoadenylate synthetase (OAS)/RNase L system. As viral replication depends on protein synthesis, many viruses have evolved mechanisms for counteracting the PKR and OAS/RNase L pathways. The murine ...
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Efficient Translation of Rotavirus mRNA Requires Simultaneous Interaction of NSP3 with the Eukaryotic Translation Initiation Factor eIF4G and the mRNA 3′ End
... tion factor was confirmed by using recombinant proteins and an in vitro translation assay in which little mRNA degradation occurs (7, ...cellular translation initiation ...the ...
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Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways
... large initiation factor eIF4G, an interaction that is inhibited by association of eIF4E with the small 4E-binding proteins ...karyotic translation initiation factor 2 ␣ (eIF2 ␣ ) on ...
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A translational rheostat for RFLAT 1 regulates RANTES expression in T lymphocytes
... RANTES factor of late-activated T lymphocytes-1 ...the translation initiation factor eIF4E increases RFLAT-1 protein, while inhibition of Mnk1, which phosphorylates eIF4E, reduces RFLAT-1 ...
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Experimental Analysis of Mimivirus Translation Initiation Factor 4a Reveals Its Importance in Viral Protein Translation during Infection of Acanthamoeba polyphaga
... initiate translation, although its specific role remains ...eukaryotic initiation factor 4a (eIF4a), the R458 protein is the prototypical member of the ATP-dependent DEAD box RNA helicase ...mimivirus ...
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Taking aim at translation for tumor therapy
... mRNA translation rates are frequently observed in human ...eukaryotic translation initiation factor 4E (eIF4E), leading to enhanced translation of numerous tumor-promoting ...
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Regulation of Tacaribe Mammarenavirus Translation: Positive 5′ and Negative 3′ Elements and Role of Key Cellular Factors
... the translation strat- egy of Tacaribe virus (TCRV), a prototype of the New World ...increases translation efficiency and that the viral 5= UTR comprises stimulatory signals while the 3= UTR,specifically the ...
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Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in non-Hodgkin lymphoma
... on translation pathway associated with ...cap-dependent translation by decreasing the association between eIF4F assembly and cap, induces apoptosis, and inhibits protein expression of c-Myc and cyclin D3 ...
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